scholarly journals Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients

Oncotarget ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 958-968 ◽  
Author(s):  
Lehui Du ◽  
Wei Yu ◽  
Xiangkun Dai ◽  
Nana Zhao ◽  
Xiang Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Patients ◽  
Gene Polymorphisms ◽  
Radiation Pneumonitis ◽  
Repair Gene ◽  
Lung Cancer Patients ◽  
Dna Repair Gene

DNA Repair Gene Polymorphisms in Non-Small-Cell Lung Cancer Patients Treated with First-Line Platinum-Containing Chemotherapy

2016 ◽  
Vol 102 (4) ◽  
pp. 367-375 ◽  
Author(s):  
Eliana Rulli ◽  
Mirko Marabese ◽  
Sheila Piva ◽  
Lucia Bonomi ◽  
Elisa Caiola ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Patients ◽  
Gene Polymorphisms ◽  
Small Cell ◽  
Small Cell Lung ◽  
First Line ◽  
Repair Gene ◽  
Lung Cancer Patients ◽  
Dna Repair Gene

Links between DNA-repair gene polymorphisms and chromosomal aberrations in lung-cancer patients

2013 ◽  
Vol 28 (4) ◽  
pp. 133-136 ◽  
Author(s):  
M. L. Bakanova ◽  
V. I. Minina ◽  
Ya. A. Savchenko ◽  
A. A. Timofeeva ◽  
O. A. Dudkina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Patients ◽  
Chromosomal Aberrations ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Lung Cancer Patients ◽  
Dna Repair Gene

Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India

2007 ◽  
Vol 134 (6) ◽  
pp. 645-652 ◽  
Author(s):  
Leelakumari Sreeja ◽  
Volga S. Syamala ◽  
Vani Syamala ◽  
Sreedharan Hariharan ◽  
Praveenkumar B. Raveendran ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Patients ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Xrcc1 Arg399gln ◽  
Lung Cancer Patients ◽  
Dna Repair Gene ◽  
Prognostic Importance

scholarly journals DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival

2015 ◽  
Vol 36 (4) ◽  
pp. 1419-1429 ◽  
Author(s):  
Yuliang Su ◽  
Huan Zhang ◽  
Fangxiu Xu ◽  
Jinyu Kong ◽  
Herbert Yu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Survival ◽  
Disease Stage ◽  
Repair Gene ◽  
Lung Cancer Patients ◽  
Homozygous Variant ◽  
Dna Repair Gene ◽  
Nsclc Patients ◽  
Repair Genes

Background: Single nucleotide polymorphisms (SNPs) in the DNA repair genes are suspected to be related to the survival of lung cancer patients due to their possible influence on DNA repair capacity (DRC). However, the study results are inconsistent. Methods: A follow-up study of 610 non-small cell lung cancer (NSCLC) patients was conducted to investigate genetic polymorphisms associated with the DNA repair genes in relation to NSCLC survival; 6 SNPs were genotyped, including XRCC1 (rs25487 G>A), hOGG1 (rs1052133 C>G), MUTYH (rs3219489 G>C), XPA (rs1800975 G>A), ERCC2 (rs1799793 G>A) and XRCC3 (rs861539 C>T). Kaplan-Meier survival curve and Cox proportional hazards regression analyses were performed. SNP-SNP interaction was also examined using the survival tree analysis. Results: Advanced disease stage and older age at diagnosis were associated with poor prognosis of NSCLC. Patients with the variant ‘G' allele of hOGG1 rs1052133 had poor overall survival compared with those with the homozygous wild ‘CC' genotype, especially in female patients, adenocarcinoma histology, early stage, light smokers and without family history of cancer. For never smoking female lung cancer patients, individuals carrying homozygous variant ‘AA' genotype of XPA had shorter survival time compared to those with wild ‘G' alleles. Furthermore, females carrying homozygous variant XPA and hOGG1 genotypes simultaneously had 2.78-fold increased risk for death. Among all 6 polymorphisms, the homozygous variant ‘AA' of XPA carriers had poor prognosis compared to the carriers of wild ‘G' alleles of XPA together with other base excision repair (BER) polymorphisms. Conclusions: Besides disease stage and age, the study found DNA repair gene polymorphisms were associated with lung cancer survival.

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