scholarly journals Norcantharidin alone or in combination with crizotinib induces autophagic cell death in hepatocellular carcinoma by repressing c-Met-mTOR signaling

Oncotarget ◽  
2017 ◽  
Vol 8 (70) ◽  
pp. 114945-114955 ◽  
Author(s):  
Chao-Yue Sun ◽  
Ying Zhu ◽  
Xiao-Feng Li ◽  
Li-Peng Tang ◽  
Zu-Qing Su ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Mtor Signaling ◽  
Autophagic Cell Death

scholarly journals Mo1443 – Mir-34A Induces Autophagic Cell Death in Hepatocellular Carcinoma by Repressing C-Met-Mtor Signaling

2019 ◽  
Vol 156 (6) ◽  
pp. S-1308-S-1309
Author(s):  
Wei Jiang ◽  
Tao LI ◽  
Qiyang Shen ◽  
Jingjing Wang ◽  
Guozhong Ji
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Mtor Signaling ◽  
Autophagic Cell Death

scholarly journals Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2462
Author(s):  
Seong Min Kim ◽  
Sang Eun Ha ◽  
Ho Jeong Lee ◽  
Shailima Rampogu ◽  
Preethi Vetrivel ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Cell Line ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Apoptotic Cell ◽  
Docking Simulation ◽  
Mtor Signaling ◽  
Autophagic Cell Death ◽  
Anti Cancer

Sinensetin (SIN) has been reported to exhibit anti-inflammatory and anti-cancer activity. However, the cellular and molecular mechanism by which SIN promotes hepatocellular carcinoma (HCC) cell death remains unclear. In the present study, we investigated the induction of cell death by SIN and its underlying mechanism in HepG2 cells, an HCC cell line. We found that SIN significantly induced cell death in HepG2 cells, whereas the proliferation rate of Thle2, human liver epithelial cells, was unaffected by SIN. SIN-treated HepG2 cells were not affected by apoptotic cell death; instead, autophagic cell death was induced through the p53-mediated AMPK/mTOR signaling pathway. Inhibition of p53 degradation led to both autophagy and apoptosis in HepG2 cells. p53 translocation led to SIN-induced autophagy, whereas p53 translocation inhibited SIN-induced apoptosis. However, SIN showed apoptosis in the p53-mutant Hep3B cell line. Molecular docking simulation of the p53 core domain showed effective binding with SIN, which was found significant compared with the known p53 activator, RITA. Collectively, these data suggest that SIN may be a potential anti-cancer agent targeting autophagic cell death in human liver cancer.

scholarly journals Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma

Oncotarget ◽  
2014 ◽  
Vol 5 (13) ◽  
pp. 4845-4854 ◽  
Author(s):  
Yu-Jen Chen ◽  
Chih-Wen Chi ◽  
Wen-Chi Su ◽  
Huey-Lan Huang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Human Hepatocellular Carcinoma ◽  
Autophagic Cell Death

scholarly journals (−)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC

2018 ◽  
Vol 19 (8) ◽  
pp. 706-714 ◽  
Author(s):  
Xiaohui Yang ◽  
Jiabei Zhu ◽  
Jianchun Wu ◽  
Nan Huang ◽  
Zhongqi Cui ◽  
...  
Keyword(s):  
Cell Death ◽  
Mtor Signaling ◽  
Autophagic Cell Death
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