scholarly journals N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation

Oncotarget ◽  
2014 ◽  
Vol 5 (17) ◽  
pp. 7625-7634 ◽  
Author(s):  
Zheng Zhang ◽  
Malika Faouzi ◽  
Junhao Huang ◽  
Dirk Geerts ◽  
Haijie Yu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Neuroblastoma Cell

PACAP Action in Nervous System Development, Regeneration, and Neuroblastoma Cell Proliferation

2006 ◽  
Vol 921 (1) ◽  
pp. 129-136 ◽  
Author(s):  
JAMES A. WASCHEK ◽  
EMANUEL M. DICICCO-BLOOM ◽  
VINCENT LELIEVRE ◽  
XINRONG ZHOU ◽  
ZHONGTING HU
Keyword(s):  
Cell Proliferation ◽  
Nervous System ◽  
System Development ◽  
Neuroblastoma Cell ◽  
Nervous System Development

Abstract 1683: ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumors

2012 ◽  
Author(s):  
Riet Hilhorst ◽  
Liesbeth Hovestad ◽  
Rik de Wijn ◽  
Dirk Pijnenburg ◽  
Rob Ruijtenbeek ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Line ◽  
Kinase Activity ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line

NLGN3 promotes neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway

2019 ◽  
Vol 857 ◽  
pp. 172423 ◽  
Author(s):  
Zuoqing Li ◽  
Wenzong Gao ◽  
Yingchun Fei ◽  
Pengfei Gao ◽  
Qigen Xie ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Neuroblastoma Cell ◽  
Akt Pathway

scholarly journals The Effects of Oleuropein on Different Clinically Types of Human Neuroblastoma Cells

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1591
Author(s):  
Zekiye Altun ◽  
Efe Ozgur Serinan ◽  
Merve Tütüncü ◽  
Safiye Aktaş ◽  
Nur Olgun
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cells ◽  
Model Organisms ◽  
Late Relapse ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma

Neuroblastoma is an embryonic tumor originating from the neural crest. It accounts for 8–10% of all childhood cancers. Although Cisplatin is used in neuroblastoma treatment, it has many side effects, such as ototoxicity, nephrotoxicity, and neurotoxicity. One herbal agent that has attracted attention in recent years is oleuropein (OLE), the active component of olive leaf. This component belongs to the polyphenol group and it has antioxidant, anti-microbial, anti-inflammatory, anti-hypertensive and anti-carcinogenic effects. It has beneficial effects against neurodegeneration in both culture cells and model organisms. Oleuropein has been shown to be increased apoptosis in SH-SY5Y neuroblastoma cell line in one study. Cisplatin (cis-diaminedichloroplatinum II (CDDP) is a widely used agent for the treatment of many different human cancers in childhood and adults with antimitotic and antineoplastic properties. CDDP is the most effective chemotherapeutic agent in specially treatment of neuroblastoma. Purpose of this study was to determine whether oleuropein and CDDP have possible anti-proliferative activity in different types of human neuroblastoma cells as representing different clinical features (bone marrow metastatic LAN-5 cells and treated with chemotherapy and beam therapy CHP-134 cells representing late relapse) investigated. Human bone marrow metastatic LAN-5 and treated with chemotherapy and beam therapy CHP-134 neuroblastoma cells representing late relapse were used in this study. The effects of OLE and CDDP on LAN-5 and CHP-134 neuroblastoma cell proliferation and apoptotic cell death was investigated using WST-1 cell proliferation and Annexin-V/PI flow cytometric assays. Oleuropein and CDDP have been shown to inhibit proliferation of LAN-5 and CHP-134 neuroblastoma cells. In further studies, it is planned to investigate different cell death mechanisms by using combination of oleuropein and cisplatin in different kind of human neuroblastoma cells.

scholarly journals Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Chantal Hoi Yin Cheung ◽  
Chia-Lang Hsu ◽  
Chao-Yin Tsuei ◽  
Tzu-Ting Kuo ◽  
Chen-Tsung Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Cancer Progression ◽  
Expression Profiles ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cells ◽  
Gene Expression Profiles ◽  
Migration Ability ◽  
Purine Synthesis ◽  
One Carbon Metabolism

Abstract MYCN-amplified (MNA) neuroblastoma is an aggressive neural crest-derived pediatric cancer. However, MYCN is indispensable for development and transcriptionally regulates extensive network of genes. Integrating anti-MYCN ChIP-seq and gene expression profiles of neuroblastoma patients revealed the metabolic enzymes, MTHFD2 and PAICS, required for one-carbon metabolism and purine biosynthesis were concomitantly upregulated, which were more susceptible to metastatic neuroblastoma. Moreover, we found that MYCN mediated the folate cycle via MTHFD2, which contributed one-carbon unit to enhance purine synthesis, and further regulated nucleotide production by PAICS in response to cancer progression. Dual knockdown of the MYCN-targeted gene pair, MTHFD2 and PAICS, in MNA neuroblastoma cells synergically reduced cell proliferation, colony formation, migration ability, and DNA synthesis. By systematically screening the compound perturbagens, the gene expression levels of MTHFD2 and PAICS were specifically suppressed by anisomycin and apicidin across cell lines, and our co-treatment results also displayed synergistic inhibition of MNA neuroblastoma cell proliferation. Collectively, targeting a combination of MYCN-targeted genes that interrupts the interconnection of metabolic pathways may overcome drug toxicity and improve the efficacy of current therapeutic agents in MNA neuroblastoma.

NOTEExpression of prolactin receptors and regulation of cell proliferation by prolactin, corticotropin-releasing factor, and corticosterone in a neuroblastoma cell line

2002 ◽  
Vol 80 (4) ◽  
pp. 475-482 ◽  
Author(s):  
Y N Mohammad ◽  
M Perone ◽  
L Wang ◽  
P M Ingleton ◽  
M G Castro ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Line ◽  
Neuroblastoma Cell ◽  
Fold Increase ◽  
Neuroblastoma Cell Line ◽  
Corticotropin Releasing Factor ◽  
Stress Axis ◽  
Prolactin Receptors ◽  
Neuro2a Cell ◽  
Neuro2a Cells

The aetiology of neuroblastoma remains obscure, although a number of neuropeptides have been implicated in its pathogenesis. Using the mouse neuroblastoma cell line Neuro2a as a model, we have investigated the mitogenic actions of prolactin (PRL) and two hypothalamo–pituitary–adrenal stress axis hormones, corticotropin-releasing factor (CRF) and corticosterone. Using established polyclonal PRL receptor antisera with immunofluorescence cytochemistry, we show that the Neuro2a cells possess immunoreactive forms of both the long and short forms of the receptor. PRL and CRF were effective as mitogens in Neuro2a cell cultures, where a 10–7 M concentration of PRL or CRF elicited a two-fold increase in the numbers of cells after 72 h (p < 0.0001). Corticosterone, however, attenuated their proliferation. These data suggest that prolactin may act to increase the proliferation and regulation of neuroblastomas and that the effects of PRL may be modified by hypothalamo–pituitary–adrenal hormones.Key words: cell proliferation, mitogens, neuroblasts, stress, cancer.

scholarly journals The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan

Cancer ◽  
2010 ◽  
Vol 117 (6) ◽  
pp. 1321-1391 ◽  
Author(s):  
Peter E. Zage ◽  
Timothy C. Graham ◽  
Lizhi Zeng ◽  
Wendy Fang ◽  
Christine Pien ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Neurotrophic Factor ◽  
Neuroblastoma Cell ◽  
Brain Derived Neurotrophic Factor
Sign in / Sign up

Export Citation Format

Share Document