scholarly journals Proteasome and heat shock protein 70 (HSP70) inhibitors as therapeutic alternative in multiple myeloma

Oncotarget ◽  
2017 ◽  
Vol 8 (70) ◽  
pp. 114698-114709 ◽  
Author(s):  
Angela Isabel Pereira Eugênio ◽  
Veruska Lia Fook-Alves ◽  
Mariana Bleker de Oliveira ◽  
Rodrigo Carlini Fernando ◽  
Daniela B. Zanatta ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Therapeutic Alternative ◽  
Hsp70 Inhibitors

Therapeutic potency of heat-shock protein-70 in the pathogenesis of colorectal cancer: current status and perspectives

2019 ◽  
Vol 97 (2) ◽  
pp. 85-90 ◽  
Author(s):  
Atena Soleimani ◽  
Elnaz Zahiri ◽  
Sajad Ehtiati ◽  
Mahtab Norouzi ◽  
Farzad Rahmani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Current Status ◽  
Cancer Cell Proliferation ◽  
Client Proteins ◽  
Or Gene ◽  
Novel Strategy ◽  
Hsp70 Inhibitors

Heat-shock protein-70 (HSP70) is critical to the folding, stability, and activity of several client proteins including many responsible for cancer cell proliferation, apoptosis, drug toxicity, and metastasis. Up-regulation of HSP70 is positively associated with increased tumorigenicity as well as poor survival in colon cancer patients, supporting the diagnostic, prognostic, and therapeutic potencies of HSP70 in colorectal cancer. The administration of specific pharmacological inhibitors or gene knock-down for HSP70 suppresses tumor progression and enhances tumor cell chemosensitivity. This review summarizes the different tumorigenic properties of HSP70 and the potential therapeutic potency of HSP70 inhibitors in terms of a novel strategy for colorectal cancer therapy, for a better understanding, and hence better management of this disease.

Ammonia aggravates emotional stress-induced gastric mucosal oxidative injury through the cancellation of heat shock protein 70 (HSP70)

2001 ◽  
Vol 120 (5) ◽  
pp. A152-A152
Author(s):  
H SUZUKI ◽  
S NAGAHASHI ◽  
M MIYAZAWA ◽  
M MORI ◽  
H NAGATA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Emotional Stress ◽  
Heat Shock Protein 70 ◽  
Oxidative Injury
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