scholarly journals Aberrant expression of STYK1 and E-cadherin confer a poor prognosis for pancreatic cancer patients

Oncotarget ◽  
2017 ◽  
Vol 8 (67) ◽  
pp. 111333-111345 ◽  
Author(s):  
Luguang Chen ◽  
Chao Ma ◽  
Yun Bian ◽  
Chengwei Shao ◽  
Tiegong Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Aberrant Expression ◽  
E Cadherin

scholarly journals Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

2007 ◽  
Vol 204 (12) ◽  
pp. 2935-2948 ◽  
Author(s):  
Kevin G. Leong ◽  
Kyle Niessen ◽  
Iva Kulic ◽  
Afshin Raouf ◽  
Connie Eaves ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Poor Prognosis ◽  
Epithelial To Mesenchymal Transition ◽  
Breast Tumors ◽  
Aberrant Expression ◽  
Mesenchymal Transition ◽  
Slug Expression ◽  
Tumor Growth And Metastasis ◽  
Notch Activation ◽  
E Cadherin

Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor prognosis is unknown. We identify Slug, a transcriptional repressor, as a novel Notch target and show that elevated levels of Slug correlate with increased expression of Jagged1 in various human cancers. Slug was essential for Notch-mediated repression of E-cadherin, which resulted in β-catenin activation and resistance to anoikis. Inhibition of ligand-induced Notch signaling in xenografted Slug-positive/E-cadherin–negative breast tumors promoted apoptosis and inhibited tumor growth and metastasis. This response was associated with down-regulated Slug expression, reexpression of E-cadherin, and suppression of active β-catenin. Our findings suggest that ligand-induced Notch activation, through the induction of Slug, promotes tumor growth and metastasis characterized by epithelial-to-mesenchymal transition and inhibition of anoikis.

Decreased TIP30 expression predicts poor prognosis in pancreatic cancer patients

2013 ◽  
Vol 134 (6) ◽  
pp. 1369-1378 ◽  
Author(s):  
Shiwei Guo ◽  
Wei Jing ◽  
Xiangui Hu ◽  
Xuyu Zhou ◽  
Lianjie Liu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Poor Prognosis

scholarly journals Venous thromboembolism predicts poor prognosis in irresectable pancreatic cancer patients

2007 ◽  
Vol 18 (10) ◽  
pp. 1660-1665 ◽  
Author(s):  
M. Mandalà ◽  
M. Reni ◽  
S. Cascinu ◽  
S. Barni ◽  
I. Floriani ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Venous Thromboembolism ◽  
Cancer Patients ◽  
Poor Prognosis

scholarly journals Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression

Oncotarget ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 12290-12300 ◽  
Author(s):  
Takamichi Igarashi ◽  
Kenichiro Araki ◽  
Takehiko Yokobori ◽  
Bolag Altan ◽  
Takahiro Yamanaka ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
E Cadherin

scholarly journals The expression of NEDD9 and E-cadherin correlates with metastasis and poor prognosis in triple-negative breast cancer patients

2016 ◽  
Vol Volume 9 ◽  
pp. 5751-5759 ◽  
Author(s):  
Peng Li ◽  
Tingting Sun ◽  
Qingzhong Yuan ◽  
Guozheng Pan ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Poor Prognosis ◽  
Triple Negative ◽  
Breast Cancer Patients ◽  
E Cadherin

Remnant pancreatic volume as an indicator of poor prognosis in pancreatic cancer patients after resection

Pancreatology ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 716-721 ◽  
Author(s):  
Ryoichi Miyamoto ◽  
Yukio Oshiro ◽  
Naoki Sano ◽  
Satoshi Inagawa ◽  
Nobuhiro Ohkohchi
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Pancreatic Volume

Aberrant expression of β-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer

2013 ◽  
Vol 44 (7) ◽  
pp. 1357-1364 ◽  
Author(s):  
Lina Xu ◽  
Yi Jiang ◽  
Jun Zheng ◽  
Guiyuan Xie ◽  
Jiao Li ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Nasopharyngeal Cancer ◽  
Aberrant Expression ◽  
E Cadherin

Elevation of Neutrophil-lymphocyte ratio at diagnosis is a biomarker of nutritional impairment and poor prognosis in pancreatic cancer patients

Pancreatology ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. S86
Author(s):  
Matteo Piciucchi ◽  
Serena Stigliano ◽  
Giulia Zerboni ◽  
Livia Archibugi ◽  
Viola Barucca ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Prognostic Value of Long Non-Coding RNA Long Intergenic Non-Protein Coding RNA 1586 in Pancreatic Cancer

2021 ◽  
Vol 11 (3) ◽  
pp. 380-385
Author(s):  
Pengju Yue ◽  
Jing Bao
Keyword(s):  
Pancreatic Cancer ◽  
Survival Rate ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Prognostic Value ◽  
Cancer Tissue ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Low Expression ◽  
Related Survival

This study investigated the prognostic value of the long non-coding RNA (lncRNA) LINC01586 in pancreatic cancer. Three pancreatic cancer patients who received pancreaticoduodenectomies in our department in January 2019 were retrospectively selected. Cancer tissue and adjacent tissue samples were collected for high-throughput sequencing of lncRNAs. Among them, 221 lncRNAs were up-regulated and 235 were down-regulated. The expression of LINC01586 was decreased in pancreatic cancer patients (logFC = -3.308). An additional 74 tissue specimens were collected from pancreatic cancer patients from January 2011 to December 2016 for low-throughput validation. Patient samples were categorized into overexpression and low expression groups, based on the median LINC01586 expression level. The LINC01586 low expression group exhibited larger tumor size than the overexpression group (P < 0.001), while the low expression group exhibited a lower cancer-related survival rate than the overexpression group (one-year cancer-related survival rate: 55.6% vs. 89.2%, P < 0.001). Further analysis confirmed that low expression of LINC01586 was associated with poor prognosis for pancreatic cancer patients (OR = 0.169, 95% CI 0.066-0.437, P = 0.000). KEGG signaling pathway analysis was used to enrich LINC01586 target genes, and were mainly related to two metabolic pathways: insulin secretion (P = 0.011) and dopaminergic synapses (P = 0.0129), with SNAP25 as the core gene. The expression of LINC01586 and SNAP25were positively correlated in pancreatic cancer (R = 0.81 and P < 0.001). Together, our results indicate that LINC01586 may be used as a biomarker for prognosis predictions in pancreatic cancer patients, and its low expression is associated with poor prognosis.

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