scholarly journals Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (68) ◽  
pp. 112530-112549 ◽  
Author(s):  
Yajun Luo ◽  
Cheng Wang ◽  
Peng Yong ◽  
Pengcheng Ye ◽  
Zilin Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Poor Prognosis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non‑coding RNA AB007962 is downregulated in gastric cancer and associated with poor prognosis

2018 ◽  
Author(s):  
Jia‑Jun Wang ◽  
Yu‑Chong Yang ◽  
Yong‑Xi Song ◽  
Peng Gao ◽  
Jing‑Xu Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2

2017 ◽  
Vol 25 (3-4) ◽  
pp. 58-67 ◽  
Author(s):  
Xiaobin Li ◽  
Zongze Li ◽  
Ziwen Liu ◽  
Jianchun Xiao ◽  
Shuting Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Poor Prognosis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA GPR65-1 is up-regulated in gastric cancer and promotes tumor growth through the PTEN-AKT-slug signaling pathway

Cell Cycle ◽  
2018 ◽  
Vol 17 (6) ◽  
pp. 759-765 ◽  
Author(s):  
Yansen Li ◽  
Zhanlong Shen ◽  
Bo Wang ◽  
Chunxiang Ye ◽  
Zhiyong Lai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Signaling Pathway ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non‑coding RNA HIT000218960 is associated with poor prognosis in patients with gastric cancer

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kunbo Dong ◽  
Li Bai ◽  
Deyong Tong ◽  
Xiuna Shi ◽  
Sirong Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Yeqian Zhang ◽  
Site Yu ◽  
Zizhen Zhang ◽  
Gang Zhao ◽  
Jia Xu
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Poor Prognosis ◽  
Positive Impact ◽  
Non Coding Rna ◽  
Mechanistic Investigation ◽  
Mechanism Of Carcinogenesis ◽  
Long Non Coding Rna ◽  
Proliferation And Invasion ◽  
Translational Level

Gastric cancer (GC) is one of the major causes of cancer deaths worldwide; however, the mechanism of carcinogenesis is complex and poorly understood. Long non-coding RNA (lncRNA) has been reported to be involved in the development of multiple cancers. Here, we identified a novel lncRNA, AK096174, which was up-regulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in GC. Our data showed that AK096174 was highly expressed in the GC tissues and cell lines (SGC-7901, AGS, BGC-823, MGC-803), and patients with higher AK096174 expression had a poorer prognosis and shorter overall survival (OS). AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. Furthermore, mechanistic investigation showed that AK096174 positively correlated with the expression of WD repeat-containing protein 66 (WDR66) gene at the translational level. Knockdown of WRD66 attenuated the positive impact of AK096174 in GC cells. The findings of the present study establish a function for AK096174 in GC progression and suggest it may serve as a potential target for GC therapy in the future.

The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer

2018 ◽  
Vol 27 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Qianjun Li ◽  
Gang Ma ◽  
Huimin Guo ◽  
Suhua Sun ◽  
Ying Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Cancer Progression ◽  
Regulatory Mechanism ◽  
Tumor Stage ◽  
Kaplan Meier ◽  
Non Coding Rna ◽  
Early Tumor ◽  
Long Non Coding Rna ◽  
Clinicopathological Variables

Background & Aims: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues.Method: 1,253 GC patients and 1,354 healthy controls were included. The frequency of the genotype del/del and the allele del of rs145204276 were compared between the patients and the controls and between different subgroups of patients classified by clinicopathological variables. The overall survival rate was analyzed according to the Kaplan-Meier method using the log-rank test.Results: The frequency of genotype del/del was significantly lower in patients than in the controls (7.0% vs. 9.1%, p = 0.001). Kaplan-Meier analysis showed that genotype del/del was significantly associated with a higher survival rate (p = 0.01). Patients with late tumor stage were found to have a significantly lower rate of genotype del/del than those with an early tumor stage (4.9% vs. 8.8%, p = 0.01). Patients with UICC III and IV were found to have a significantly lower rate of genotype del/del than those with UICC I and II (5.3% vs. 8.1%, p = 0.02).Conclusion: The variant rs145204276 of GAS5 is associated with the development and prognosis of GC. The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.

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