scholarly journals Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients

Oncotarget ◽  
2017 ◽  
Vol 8 (62) ◽  
pp. 105115-105125 ◽  
Author(s):  
Ahmed A. Al-Qahtani ◽  
Mashael R. Al-Anazi ◽  
Nyla Nazir ◽  
Rohit Ghai ◽  
Ayman A. Abdo ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Disease Progression ◽  
Gene Mutations ◽  
Liver Disease Progression ◽  
B Virus ◽  
X Gene

scholarly journals Impact of Hepatitis B Virus (HBV) X Gene Mutations on Hepatocellular Carcinoma Development in Chronic HBV Infection

2013 ◽  
Vol 20 (1) ◽  
pp. 127-127 ◽  
Author(s):  
Jong-Han Lee ◽  
Kwang-Hyub Han ◽  
Jae Myun Lee ◽  
Jeon Han Park ◽  
Hyon-Suk Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gene Mutations ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
B Virus ◽  
Chronic Hbv ◽  
X Gene

scholarly journals PP-097 Role of hepatitis B virus genotypes, BCP, precore/core and X gene mutations and the risk of hepatocellular carcinoma

2009 ◽  
Vol 13 ◽  
pp. S75
Author(s):  
Mohammad Asim ◽  
Sunil Kumar Polipalli ◽  
Nargis Begum ◽  
Istaq Ahmed ◽  
Luqman A. Khan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gene Mutations ◽  
B Virus ◽  
Virus Genotypes ◽  
X Gene

Hepatitis B virus BCP, precore/core, X gene mutations/genotypes and the risk of hepatocellular carcinoma in India

2010 ◽  
Vol 82 (7) ◽  
pp. 1115-1125 ◽  
Author(s):  
Mohammad Asim ◽  
Abdul Malik ◽  
Manash P. Sarma ◽  
Sunil K. Polipalli ◽  
Nargis Begum ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gene Mutations ◽  
B Virus ◽  
X Gene

scholarly journals Vitamin D receptor ApaI polymorphism associated with progression of liver disease in Vietnamese patients chronically infected with hepatitis B virus

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Nghiem Xuan Hoan ◽  
Nguyen Khuyen ◽  
Dao Phuong Giang ◽  
Mai Thanh Binh ◽  
Nguyen Linh Toan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Outcome ◽  
Dominant Model ◽  
Liver Disease Progression ◽  
Codominant Model ◽  
B Virus ◽  
Vdr Polymorphisms

Abstract Background Vitamin D derivatives and their receptor (VDR) are potent modulators of immune responses in various diseases including malignancies as well as in metabolic and infectious disorders. The impact of vitamin D receptor polymorphisms on clinical outcomes of hepatitis B virus (HBV) infection is not well understood. This study aims to investigate the potential role of VDR polymorphisms (TaqI, FokI, ApaI, and BsmI) in Vietnamese HBV infected patients and to correlate these polymorphisms with the progression of HBV-related liver disease. Methods Four hundred forty-three HBV infected patients of the three clinically well-defined subgroups chronic hepatitis B (CHB, n = 183), liver cirrhosis (LC, n = 89) and hepatocellular carcinoma (HCC, n = 171) and 238 healthy individuals (HC) were enrolled. VDR polymorphisms were genotyped by DNA sequencing and in-house validated ARMS assays. Logistic regression models were applied in order to determine the association of VDR polymorphisms with manifest HBV infection as well as with progression of related liver diseases mulin different genetic models. Results The VDR ApaI CA genotype was less frequent in HCC than in CHB patients in different genetic models (codominant model, OR = 0.5, 95%CI = 0.3–0.84, P = 0.004; dominant model, OR = 0.46, 95%CI = 0.27–0.76, P = 0.0023). In the recessive model, the genotype ApaI AA was found more frequently among HCC compared to CHB patients (OR = 2.56, 95%CI = 1.01–6.48, P = 0.04). Similarly, the ApaI CA genotype was less frequent in HCC than in non-HCC group codominant model, OR = 0.6, 95%CI = 0.4–0.98, dominant model, P = 0.04 and OR = 0.6, 95%CI = 0.38–0.90, P = 0.017). The ApaI genotypes CA and AA was significantly associated with higher levels of liver enzymes, bilirubin, and HBV DNA (P < 0.05). No association between TaqI, FokI and BsmI polymorphisms and any clinical outcome as well as liver disease progression was found. Conclusions Among the four investigated VDR polymorphisms, ApaI is associated with clinical outcome and liver disease progression in Vietnamese HBV infected patients.

Interleukin-18 promoter polymorphisms and the disease progression of Hepatitis B virus-related liver disease

2009 ◽  
Vol 153 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Kiyoshi Migita ◽  
Kazumi Sawakami-Kobayashi ◽  
Yumi Maeda ◽  
Kazuhiko Nakao ◽  
Susumu Kondoh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Disease Progression ◽  
Interleukin 18 ◽  
Promoter Polymorphisms ◽  
B Virus ◽  
Related Liver Disease
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