scholarly journals Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?

Oncotarget ◽  
2017 ◽  
Vol 8 (63) ◽  
pp. 107176-107187 ◽  
Author(s):  
Kylie Van Hoesen ◽  
Sonia Meynier ◽  
Pascale Ribaux ◽  
Patrick Petignat ◽  
Florence Delie ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Cancer Patients ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Cell Targeting ◽  
Promising Tool ◽  
Cancer Cell Targeting

scholarly journals Chemotherapeutic Efficacy of Implantable Antineoplastic-Treatment Protocols in an Optimal Mouse Model for Human Ovarian Carcinoma Cell Targeting

2018 ◽  
Vol 19 (10) ◽  
pp. 3030 ◽  
Author(s):  
Jonathan M. Pantshwa ◽  
Khadija Rhoda ◽  
Sarah J. Clift ◽  
Priyamvada Pradeep ◽  
Yahya E. Choonara ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Mouse Model ◽  
Ovarian Carcinoma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Targeting ◽  
In Situ Forming ◽  
Human Ovarian Carcinoma

The present study aimed to design and develop a nanocomposite drug delivery system employing an antineoplastic-loaded antibody functionalized nanomicelle encapsulated within a Chitosan–Poly(vinylpyrrolidone)–Poly(N-isopropylacrylamide) (C–P–N) hydrogel to form an in situ forming implant (ISFI), responsive to temperature and pH for cancer cell-targeting following intraperitoneal implantation. The optimum nanomicelle formulation was surface-functionalized with anti-MUC 16 (antibody) for the targeted delivery of methotrexate to human ovarian carcinoma (NIH:OVCAR-5) cells in Athymic nude mice that expressed MUC16, as a preferential form of intraperitoneal ovarian cancer (OC) chemotherapy. The cross-linked interpenetrating C–P–N hydrogel was synthesized for the preparation of an in situ-forming implant (ISFI). Subsequently, the ISFI was fabricated by encapsulating a nanocomposite comprising of anti-MUC16 (antibody) functionalized methotrexate (MTX)-loaded poly(N-isopropylacrylamide)-b-poly(aspartic acid) (PNIPAAm-b-PASP) nanomicelles (AF(MTX)NM’s) within the cross-linked C–P–N hydrogel. This strategy enabled specificity and increased the residence time of the nanomicelles at tumor sites over a period exceeding one month, enhancing uptake of drugs and preventing recurrence and chemo-resistance. Chemotherapeutic efficacy was tested on the optimal ovarian tumor-bearing Athymic nude mouse model and the results demonstrated tumor regression including reduction in mouse weight and tumor size, as well as a significant (p < 0.05) reduction in mucin 16 levels in plasma and ascitic fluid, and improved survival of mice after treatment with the experimental anti-MUC16/CA125 antibody-bound nanotherapeutic implant drug delivery system (ISFI) (p < 0.05). The study also concluded that ISFI could potentially be considered an important immuno-chemotherapeutic agent that could be employed in human clinical trials of advanced, and/or recurring, metastatic epithelial ovarian cancer (EOC). The development of this ISFI may circumvent the treatment flaws experienced with conventional systemic therapies, effectively manage recurrent disease and ultimately prolong disease-free intervals in ovarian cancer patients.

Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures

Nano Research ◽  
2015 ◽  
Vol 9 (1) ◽  
pp. 139-148 ◽  
Author(s):  
Yu Yang ◽  
Jingjing Liu ◽  
Xiaoqi Sun ◽  
Liangzhu Feng ◽  
Wenwen Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Near Infrared ◽  
Infrared Light ◽  
Cell Targeting ◽  
Near Infrared Light ◽  
Cancer Cell Targeting

Polymersomes conjugated with des-octanoyl ghrelin and folate as a BBB-penetrating cancer cell-targeting delivery system

Biomaterials ◽  
2014 ◽  
Vol 35 (13) ◽  
pp. 4066-4081 ◽  
Author(s):  
Yung-Chu Chen ◽  
Chi-Feng Chiang ◽  
Li-Fang Chen ◽  
Po-Chin Liang ◽  
Wen-Yuan Hsieh ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Delivery System ◽  
Cell Targeting ◽  
Targeting Delivery ◽  
Cancer Cell Targeting

scholarly journals Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system

2015 ◽  
Vol 47 (3) ◽  
pp. 1070-1076 ◽  
Author(s):  
ZHAO LI ◽  
LIPING SUN ◽  
ZAIJUN LU ◽  
XUANTAO SU ◽  
QIFENG YANG ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nanoparticle Drug Delivery
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