scholarly journals Benzodiazepine drug use and cancer risk: a dose-response meta analysis of prospective cohort studies

Oncotarget ◽  
2017 ◽  
Vol 8 (60) ◽  
pp. 102381-102391 ◽  
Author(s):  
Tao Zhang ◽  
Xiaowen Yang ◽  
Jianrui Zhou ◽  
Pei Liu ◽  
Hui Wang ◽  
...  
Oncotarget ◽  
2018 ◽  
Vol 9 (29) ◽  
pp. 20807-20815 ◽  
Author(s):  
Massimiliano Berretta ◽  
Agnieszka Micek ◽  
Alessandra Lafranconi ◽  
Sabrina Rossetti ◽  
Raffaele Di Francia ◽  
...  

Oncotarget ◽  
2017 ◽  
Vol 9 (19) ◽  
pp. 15090-15100 ◽  
Author(s):  
Jun Shi ◽  
Weidong Leng ◽  
Lunhua Zhao ◽  
Cai Deng ◽  
Chenli Xu ◽  
...  

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33990-34000 ◽  
Author(s):  
Limin Zhao ◽  
Xiaoqin Tian ◽  
Xueyan Duan ◽  
Yongxiu Ye ◽  
Min Sun ◽  
...  

2016 ◽  
Vol 116 (1) ◽  
pp. 158-166 ◽  
Author(s):  
Khemayanto Hidayat ◽  
Guo-Chong Chen ◽  
Ru Zhang ◽  
Xuan Du ◽  
Sheng-Yi Zou ◽  
...  

AbstractFindings from observational studies have suggested a possible relation between Ca and breast cancer risk. However, the results of these studies are inconclusive, and the dose–response relationship between Ca intake and risk of breast cancer remains to be determined. A meta-analysis of prospective studies was conducted to address these issues. PubMed and Embase databases were searched for relevant studies concerning the association between Ca intake and breast cancer up to March 2016. The summary relative risks (RR) with 95 % CI were calculated with a random-effects model. The final analysis included eleven prospective cohort studies involving 26 606 cases and 872 895 participants. The overall RR of breast cancer for high v. low intake of Ca was 0·92 (95 % CI 0·85, 0·99), with moderate heterogeneity (P=0·026, I2=44·2 %). In the subgroup analysis, the inverse association appeared stronger for premenopausal breast cancer (RR 0·75; 95 % CI 0·59, 0·96) than for postmenopausal breast cancer (RR 0·94; 95 % CI 0·87, 1·01). Dose–response analysis revealed that each 300 mg/d increase in Ca intake was associated with 2 % (RR 0·98; 95 % CI 0·96, 0·99), 8 % (RR 0·92; 95 % CI 0·87, 0·98) and 2 % (RR 0·98; 95 % CI 0·97, 0·99) reduction in the risk of total, premenopausal and postmenopausal breast cancer, respectively. Our findings suggest an inverse dose–response association between Ca intake and risk of breast cancer.


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