scholarly journals An important discovery on combination of irreversible electroporation and allogeneic natural killer cell immunotherapy for unresectable pancreatic cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (60) ◽  
pp. 101795-101807 ◽  
Author(s):  
Mao Lin ◽  
Mohammed Alnaggar ◽  
Shuzhen Liang ◽  
Xiaohua Wang ◽  
Yinqing Liang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Irreversible Electroporation ◽  
Unresectable Pancreatic Cancer ◽  
Allogeneic Natural Killer Cell ◽  
Cell Immunotherapy

scholarly journals Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome

2018 ◽  
Vol 48 (5) ◽  
pp. 1882-1893 ◽  
Author(s):  
Mohammed Alnaggar ◽  
Mao Lin ◽  
Adnan Mesmar ◽  
Shuzhen Liang ◽  
Ammar Qaid ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cell ◽  
Irreversible Electroporation ◽  
Stage Iv ◽  
Clinical Effectiveness ◽  
Survival Outcome ◽  
Cell Immunotherapy

Background/Aims: We evaluated the clinical effectiveness of irreversible electroporation (IRE) in combination with immunotherapy using allogenic natural killer cells (NK) for stage IV hepatocellular carcinoma (HCC). Methods: The study involved 40 patients with stage IV HCC who were divided equally into two groups: 1) simple IRE; and 2) IRE plus allogenic NK cells (IRE-NK); we mainly assessed the overall survival (OS). Results: The effect of the IRE-NK treatment was synergistic, i.e., not only did it enhance immune function, it also decreased alpha-fetoprotein expression and showed significantly good clinical effectiveness. At the median 7.6-month follow-up (range, 3.8–12.1 months), median OS was higher in the IRE-NK group (10.1 months) than in the IRE group (8.9 months, P = 0.0078). Conclusion: IRE combined with allogeneic NK cell immunotherapy significantly increases the median OS of patients with stage IV HCC.

scholarly journals IMMU-22. NATURAL KILLER CELL IMMUNOTHERAPY FOR DIFFUSE INTRINSIC PONTINE GLIOMA

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i103-i103 ◽  
Author(s):  
Javiera Bravo-Alegria ◽  
Shinji Maegawa ◽  
Keri Callegari ◽  
Bridget Kennis ◽  
Wencai Ma ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Diffuse Intrinsic Pontine Glioma ◽  
Pontine Glioma ◽  
Cell Immunotherapy

scholarly journals Natural killer cell immunotherapy to target stem-like tumor cells

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Steven K. Grossenbacher ◽  
Robert J. Canter ◽  
William J. Murphy
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Tumor Cells ◽  
Killer Cell ◽  
Cell Immunotherapy

scholarly journals In vitro Natural Killer Cell Immunotherapy for Medulloblastoma

2013 ◽  
Vol 3 ◽  
Author(s):  
Lucia Fernández ◽  
Raquel Portugal ◽  
Jaime Valentín ◽  
Roberto Martín ◽  
Hannah Maxwell ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Immunotherapy
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