scholarly journals Small interfering RNA (siRNA)-mediated knockdown of macrophage migration inhibitory factor (MIF) suppressed cyclin D1 expression and hepatocellular carcinoma cell proliferation

Oncotarget ◽  
2014 ◽  
Vol 5 (14) ◽  
pp. 5570-5580 ◽  
Author(s):  
Xiao-hui Huang ◽  
Wei-hua Jian ◽  
Zhao-feng Wu ◽  
Jie Zhao ◽  
Hua Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Cyclin D1 ◽  
Migration Inhibitory Factor ◽  
Small Interfering Rna ◽  
Macrophage Migration Inhibitory Factor ◽  
Carcinoma Cell ◽  
Macrophage Migration ◽  
Hepatocellular Carcinoma Cell ◽  
Interfering Rna

scholarly journals Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769141 ◽  
Author(s):  
Qing Gou ◽  
ShuJiao He ◽  
ZeJian Zhou
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Lines ◽  
Small Interfering Rna ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Carcinoma Cell Lines ◽  
Hepatocellular Carcinoma Cell ◽  
Interfering Rna ◽  
Methyltransferase 1

Hepatocellular carcinoma is the most common subtype of liver cancer. Protein arginine N-methyltransferase 1 was shown to be upregulated in various cancers. However, the role of protein arginine N-methyltransferase 1 in hepatocellular carcinoma progression remains incompletely understood. We investigated the clinical and functional significance of protein arginine N-methyltransferase 1 in a series of clinical hepatocellular carcinoma samples and a panel of hepatocellular carcinoma cell lines. We performed suppression analysis of protein arginine N-methyltransferase 1 using small interfering RNA to determine the biological roles of protein arginine N-methyltransferase 1 in hepatocellular carcinoma. In addition, the expression of epithelial-mesenchymal transition indicators was verified by western blotting in hepatocellular carcinoma cell lines after small interfering RNA treatment. Protein arginine N-methyltransferase 1 expression was found to be significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues. Moreover, downregulation of protein arginine N-methyltransferase 1 in hepatocellular carcinoma cells by small interfering RNA could inhibit cell proliferation, migration, and invasion in vitro. These results indicate that protein arginine N-methyltransferase 1 may contribute to hepatocellular carcinoma progression and serves as a promising target for the treatment of hepatocellular carcinoma patients.

scholarly journals Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

2018 ◽  
Vol 109 (11) ◽  
pp. 3543-3553 ◽  
Author(s):  
Yasuo Takashima ◽  
Kenichi Horisawa ◽  
Miyako Udono ◽  
Yasuyuki Ohkawa ◽  
Atsushi Suzuki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Transcription Factors ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Combinatorial Expression
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