scholarly journals Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model

Oncotarget ◽  
2014 ◽  
Vol 5 (14) ◽  
pp. 5547-5558 ◽  
Author(s):  
Juozas Vasiliauskas ◽  
Madison A. Nashu ◽  
Peterson Pathrose ◽  
Sandra L. Starnes ◽  
Susan E. Waltz
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Hepatocyte Growth Factor ◽  
Tumor Growth ◽  
Prostate Tumor ◽  
Tramp Mouse ◽  
Hepatocyte Growth

Hepatocyte Growth Factor and Macrophage-stimulating Protein “Hinge” Analogs to Treat Pancreatic Cancer

2019 ◽  
Vol 19 (10) ◽  
pp. 782-795
Author(s):  
John W. Wright ◽  
Kevin J. Church ◽  
Joseph W. Harding
Keyword(s):  
Pancreatic Cancer ◽  
Signal Transduction ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tumor Growth ◽  
Receptor Activation ◽  
Signal Transduction Pathways ◽  
Met Receptor ◽  
Macrophage Stimulating Protein ◽  
Hepatocyte Growth

Pancreatic cancer (PC) ranks twelfth in frequency of diagnosis but is the fourth leading cause of cancer related deaths with a 5 year survival rate of less than 7 percent. This poor prognosis occurs because the early stages of PC are often asymptomatic. Over-expression of several growth factors, most notably vascular endothelial growth factor (VEGF), has been implicated in PC resulting in dysfunctional signal transduction pathways and the facilitation of tumor growth, invasion and metastasis. Hepatocyte growth factor (HGF) acts via the Met receptor and has also received research attention with ongoing efforts to develop treatments to block the Met receptor and its signal transduction pathways. Macrophage-stimulating protein (MSP), and its receptor Ron, is also recognized as important in the etiology of PC but is less well studied. Although the angiotensin II (AngII)/AT1 receptor system is best known for mediating blood pressure and body water/electrolyte balance, it also facilitates tumor vascularization and growth by stimulating the expression of VEGF. A metabolite of AngII, angiotensin IV (AngIV) has sequence homology with the “hinge regions” of HGF and MSP, key structures in the growth factor dimerization processes necessary for Met and Ron receptor activation. We have developed AngIV-based analogs designed to block dimerization of HGF and MSP and thus receptor activation. Norleual has shown promise as tested utilizing PC cell cultures. Results indicate that cell migration, invasion, and pro-survival functions were suppressed by this analog and tumor growth was significantly inhibited in an orthotopic PC mouse model.

Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

2011 ◽  
Vol 6 (3) ◽  
pp. 620-630 ◽  
Author(s):  
Hiroki Tojima ◽  
Satoru Kakizaki ◽  
Takashi Kosone ◽  
Norio Horiguchi ◽  
Yuichi Yamazaki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Hepatocyte Growth Factor ◽  
Nonalcoholic Steatohepatitis ◽  
Liver Inflammation ◽  
Hepatocyte Growth

scholarly journals Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease.

1998 ◽  
Vol 101 (9) ◽  
pp. 1827-1834 ◽  
Author(s):  
S Mizuno ◽  
T Kurosawa ◽  
K Matsumoto ◽  
Y Mizuno-Horikawa ◽  
M Okamoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Renal Disease ◽  
Hepatocyte Growth Factor ◽  
Renal Fibrosis ◽  
Chronic Renal Disease ◽  
Hepatocyte Growth

Hepatocyte Growth Factor Promotes Tumor Growth in a NovelIn VivoModel of Human Lung Cancer

2001 ◽  
Vol 24 (5) ◽  
pp. 556-562 ◽  
Author(s):  
Joseph M. Pilewski ◽  
Thomas S. Bumbalo ◽  
Autumn Gaither Davis ◽  
Jill M. Siegfried
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tumor Growth ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Hepatocyte Growth

scholarly journals Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor

Oncogene ◽  
1998 ◽  
Vol 17 (23) ◽  
pp. 3045-3054 ◽  
Author(s):  
Kazuhiko Date ◽  
Kunio Matsumoto ◽  
Keiji Kuba ◽  
Hideo Shimura ◽  
Masao Tanaka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tumor Growth ◽  
Inhibition Of Tumor Growth ◽  
Hepatocyte Growth ◽  
Tumor Growth And Invasion

scholarly journals Molecular Therapy Targeting Sonic Hedgehog and Hepatocyte Growth Factor Signaling in a Mouse Model of Medulloblastoma

2010 ◽  
Vol 9 (9) ◽  
pp. 2627-2636 ◽  
Author(s):  
Valerie Coon ◽  
Tamara Laukert ◽  
Carolyn A. Pedone ◽  
John Laterra ◽  
K. Jin Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Hepatocyte Growth Factor ◽  
Sonic Hedgehog ◽  
Molecular Therapy ◽  
Growth Factor Signaling ◽  
Hepatocyte Growth
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