scholarly journals An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine

Oncotarget ◽  
2014 ◽  
Vol 5 (14) ◽  
pp. 5218-5233 ◽  
Author(s):  
Leonel Maldonado ◽  
Mariana Brait ◽  
Christina Michailidi ◽  
Enrico Munari ◽  
Tina Driscoll ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Risk Prediction ◽  
Transurethral Resection ◽  
Recurrence Risk ◽  
Urothelial Cell ◽  
Low Grade ◽  
Urothelial Cell Carcinoma ◽  
Marker Panel ◽  
Epigenetic Marker ◽  
Potential Use

The Effect of Intravesical Mitomycin C on Recurrence of Newly Diagnosed Superficial Bladder Cancer

2021 ◽  
pp. 129-134
Author(s):  
Vikram M. Narayan
Keyword(s):  
Cell Carcinoma ◽  
Mitomycin C ◽  
Transurethral Resection ◽  
Disease Recurrence ◽  
Urothelial Cell ◽  
Newly Diagnosed ◽  
Urothelial Cell Carcinoma ◽  
Risk Of Disease ◽  
Carcinoma Of The Bladder ◽  
Reduced Risk

This study summarizes the seminal study assessing the instillation of intravesical mitomycin C after transurethral resection in patients with newly diagnosed Ta or T1 transitional urothelial cell carcinoma of the bladder. The study randomized patients with immediate mitomycin C, immediate mitomycin C plus four weekly installations, versus no further treatment. The main findings were that a single immediate instillation of mitomycin C following transurethral resection of a suspected noninvasive urothelial cell carcinoma confers a reduced risk of disease recurrence.

Higher Expression of miR-182 in Cytology Specimens of High-Grade Urothelial Cell Carcinoma: A Potential Diagnostic Marker

2015 ◽  
Vol 59 (1) ◽  
pp. 109-112 ◽  
Author(s):  
Shuanzeng Wei ◽  
Zhanyong Bing ◽  
Yuan Yao ◽  
Stephen R. Master ◽  
Prabodh Gupta
Keyword(s):  
Cell Carcinoma ◽  
Noncoding Rna ◽  
Urothelial Cell ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Cell Carcinoma ◽  
Rna Molecules ◽  
History Of ◽  
Potential Alternative ◽  
Normal Controls

Objective: MicroRNAs (miRs) are short noncoding RNA molecules that posttranscriptionally modulate protein expression. There are distinct miR alterations characterizing urothelial cell carcinoma (UCC) of the urinary bladder. Study Design: In this study, we investigate the possibility of using miR as a noninvasive marker in the screening of UCC. The total RNA was extracted from 75 cytology specimens including bladder or renal washings and voided urines. Cases comprise UCC (21 high grade and 6 low grade), 25 normal controls and 23 cases with a history of UCC but negative at the time of testing (negative with a positive history). The expressions of miR-96, miR-182, miR-183, miR-200c, miR-21, miR-141 and miR-30b were determined using quantitative TaqMan real-time PCR. Results and Conclusion: This study shows that the level of miR-182 is higher in cytology specimens from high-grade UCC patients as compared to normal controls. Measuring miR-182 may provide a potential alternative or adjunct approach for screening high-grade UCC.

CARBONIC ANHYDRASE IX AS A NOVEL TARGET FOR DETECTION AND THERAPY OF LOW GRADE UROTHELIAL CELL CARCINOMA

2009 ◽  
Vol 181 (4S) ◽  
pp. 70-70
Author(s):  
Jennifer Clebanoff ◽  
Jian Yu Rao ◽  
Dominic Lung ◽  
Mya Noe ◽  
Po Chu Fung ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Carbonic Anhydrase Ix ◽  
Low Grade ◽  
Urothelial Cell Carcinoma ◽  
Novel Target

scholarly journals The role of WNT signalling in urothelial cell carcinoma

2015 ◽  
Vol 97 (7) ◽  
pp. 481-486 ◽  
Author(s):  
I Ahmad
Keyword(s):  
Cell Carcinoma ◽  
Metastatic Potential ◽  
Wnt Signalling ◽  
Urothelial Cell ◽  
Tumour Suppressor Genes ◽  
Low Grade ◽  
Urothelial Cell Carcinoma ◽  
Muscle Invasive ◽  
Considerable Morbidity

Urothelial cell carcinoma (UCC) of the bladder is one of the most common malignancies, causing considerable morbidity and mortality worldwide. It is unique among the epithelial carcinomas as two distinct pathways to tumourigenesis appear to exist: low grade, recurring papillary tumours usually contain oncogenic mutations in FGFR3 or HRAS whereas high grade, muscle invasive tumours with metastatic potential generally have defects in the pathways controlled by the tumour suppressors p53 and retinoblastoma. Over the last two decades, a number of transgenic mouse models of UCC, containing deletions or mutations of key tumour suppressor genes or oncogenes, have helped us understand the mechanisms behind tumour development. In this summary, I present my work investigating the role of the WNT signalling cascade in UCC.

scholarly journals ANALYSIS OF THE EXPRESSION OF FAS/CD95 AND HSP70 IN LOW AND HIGH GRADE UROTHELIAL CELL CARCINOMA OF THE BLADDER

2017 ◽  
Vol 53 (4) ◽  
pp. 247
Author(s):  
Heryanto Heryanto ◽  
Etty Hary Kusumastuti ◽  
Anny Setijo Rahaju
Keyword(s):  
Cell Carcinoma ◽  
Transitional Cell ◽  
Urothelial Cell ◽  
Hsp70 Expression ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Cell Carcinoma ◽  
Cross Sectional ◽  
Carcinoma Of The Bladder ◽  
Spearman Test

Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis. Fas/CD95 has a role in apoptotic process, whereas HSP70 has an antiapoptotic role. This study aimed to analyze the expression of Fas/CD95 and HSP70 in low grade and high grade urothelial cell carcinoma in the bladder. This was an analytic observational study with cross sectional approach. Population and sample were paraffin blocks of urothelial cell carcinoma in the Laboratory of Anatomic Pathology, Dr. Soetomo Hospital, Surabaya in the period of January 2011-December 2016. Each grading of urothelial cell carcinoma was randomly sampled. Immunohistochemystry with Fas/CD95 and HSP70 were performed. Expression of Fas/CD95 and HSP70 were assessed semiquantitatively. Expression of Fas/CD95 and HSP70  were analyzed using Mann-Whitney test and Spearman test. The results showed there was significant different in expression of Fas/CD95 and HSP70 in low and high grades in urothelial cell carcinoma. There was no significant correlation between the expression of Fas/CD95 and HSP70 in urothelial cell carcinoma.  As a conclusion, the role of CD95 and HSP70 expression can be useful as marker for the diagnosis, especially in the determination of the grade of differentiation.

scholarly journals Pulmonary and hepatic metastases of low-grade urothelial cell carcinoma; A case report

2021 ◽  
Vol 39 ◽  
pp. 101836
Author(s):  
Michael Smith ◽  
Tirth Patel ◽  
Mark Vangorder ◽  
James Siegert
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Hepatic Metastases ◽  
Urothelial Cell ◽  
Low Grade ◽  
Urothelial Cell Carcinoma
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