scholarly journals MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells

Oncotarget ◽  
2017 ◽  
Vol 8 (61) ◽  
pp. 103261-103273 ◽  
Author(s):  
Guodong Xiao ◽  
Xiang Li ◽  
Gang Li ◽  
Boxiang Zhang ◽  
Chongwen Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Notch Signaling ◽  
Signaling Activity ◽  
Estrogen Induction

scholarly journals Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling

Oncogene ◽  
2014 ◽  
Vol 34 (30) ◽  
pp. 3935-3945 ◽  
Author(s):  
P Mo ◽  
Q Zhou ◽  
L Guan ◽  
Y Wang ◽  
W Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Notch Signaling ◽  
Cancer Progression ◽  
Colorectal Cancer Progression

scholarly journals Mechanisms of ligand-mediated inhibition in Notch signaling activity inDrosophila

2010 ◽  
Vol 239 (3) ◽  
pp. 798-805 ◽  
Author(s):  
Ulla-Maj Fiuza ◽  
Thomas Klein ◽  
Alfonso Martinez Arias ◽  
Penelope Hayward
Keyword(s):  
Notch Signaling ◽  
Signaling Activity

Notch signaling and its role in breast cancer

10.2741/2394 ◽  
2007 ◽  
Vol 12 (8-12) ◽  
pp. 4370 ◽  
Author(s):  
Fangting Wu
Keyword(s):  
Breast Cancer ◽  
Notch Signaling

scholarly journals Notch signaling in breast cancer: From pathway analysis to therapy

2019 ◽  
Vol 461 ◽  
pp. 123-131 ◽  
Author(s):  
B. Madhu Krishna ◽  
Samir Jana ◽  
Jyotsana Singhal ◽  
David Horne ◽  
Sanjay Awasthi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Notch Signaling ◽  
Pathway Analysis

scholarly journals An RBPJ-Drosophila Model Reveals Dependence of RBPJ Protein Stability on the Formation of Transcription–Regulator Complexes

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1252 ◽  
Author(s):  
Gahr ◽  
Brändle ◽  
Zimmermann ◽  
Nagel
Keyword(s):  
Protein Stability ◽  
Notch Signaling ◽  
Genome Engineering ◽  
Notch Pathway ◽  
Notch Receptor ◽  
Model Systems ◽  
Congenital Diseases ◽  
Murine Homologue ◽  
Pathway Regulation ◽  
Signaling Activity

Notch signaling activity governs widespread cellular differentiation in higher animals, including humans, and is involved in several congenital diseases and different forms of cancer. Notch signals are mediated by the transcriptional regulator RBPJ in a complex with activated Notch (NICD). Analysis of Notch pathway regulation in humans is hampered by a partial redundancy of the four Notch receptor copies, yet RBPJ is solitary, allowing its study in model systems. In Drosophila melanogaster, the RBPJ orthologue is encoded by Suppressor of Hairless [Su(H)]. Using genome engineering, we replaced Su(H) by murine RBPJ in order to study its function in the fly. In fact, RBPJ largely substitutes for Su(H)’s function, yet subtle phenotypes reflect increased Notch signaling activity. Accordingly, the binding of RBPJ to Hairless (H) protein, the general Notch antagonist in Drosophila, was considerably reduced compared to that of Su(H). An H-binding defective RBPJLLL mutant matched the respective Su(H)LLL allele: homozygotes were lethal due to extensive Notch hyperactivity. Moreover, RBPJLLL protein accumulated at lower levels than wild type RBPJ, except in the presence of NICD. Apparently, RBPJ protein stability depends on protein complex formation with either H or NICD, similar to Su(H), demonstrating that the murine homologue underlies the same regulatory mechanisms as Su(H) in Drosophila. These results underscore the importance of regulating the availability of RBPJ protein to correctly mediate Notch signaling activity in the fly.

scholarly journals Radiation-Induced Notch Signaling in Breast Cancer Stem Cells

2013 ◽  
Vol 87 (3) ◽  
pp. 609-618 ◽  
Author(s):  
Chann Lagadec ◽  
Erina Vlashi ◽  
Yazeed Alhiyari ◽  
Tiffany M. Phillips ◽  
Milana Bochkur Dratver ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Notch Signaling ◽  
Breast Cancer Stem Cells ◽  
Radiation Induced
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