scholarly journals Identification of potential tissue-specific cancer biomarkers and development of cancer versus normal genomic classifiers

Oncotarget ◽  
2017 ◽  
Vol 8 (49) ◽  
pp. 85692-85715 ◽  
Author(s):  
Akram Mohammed ◽  
Greyson Biegert ◽  
Jiri Adamec ◽  
Tomáš Helikar
Keyword(s):  
Cancer Biomarkers ◽  
Tissue Specific ◽  
Specific Cancer

scholarly journals ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

Nature ◽  
2020 ◽  
Vol 579 (7797) ◽  
pp. 130-135 ◽  
Author(s):  
John Alec Moral ◽  
Joanne Leung ◽  
Luis A. Rojas ◽  
Jennifer Ruan ◽  
Julia Zhao ◽  
...  
Keyword(s):  
Tissue Specific ◽  
Cancer Immunity ◽  
Specific Cancer

scholarly journals Tissue-specific cancer paradox and mutation rates

2014 ◽  
Author(s):  
Valentina Agoni
Keyword(s):  
Expression Patterns ◽  
Mutation Rates ◽  
Tissue Specific ◽  
Specific Cancer

Some genes have ubiquitous expression patterns in an individual's cells, thus a paradox exists whereby mutations in such genes are only strongly associated with cancers of specific tissues. As these genes are ubiquitously expressed in the body's cells and thereby have functions in -potentially- all tissue types, then surely their resulting defects would manifest as cancers in all tissues? We hypothesize that the different susceptibility to mutations could explain the ‘tissue-specific’ paradox for cancer.

Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26

2000 ◽  
Vol 29 (3) ◽  
pp. 240-255 ◽  
Author(s):  
Wun-Shaing W. Chang ◽  
Nien-Tzu Chang ◽  
Sheng-Chieh Lin ◽  
Cheng-Wen Wu ◽  
Felicia Y.-H. Wu
Keyword(s):  
Human Chromosome ◽  
Gene Cluster ◽  
Chromosome Band ◽  
Serpin Gene ◽  
Tissue Specific ◽  
Specific Cancer ◽  
Human Chromosome Band

Racial and tissue-specific cancer risk associated with PARP1 (ADPRT) Val762Ala polymorphism: a meta-analysis

2012 ◽  
Vol 39 (12) ◽  
pp. 11061-11072 ◽  
Author(s):  
Noel Pabalan ◽  
Ofelia Francisco-Pabalan ◽  
Hamdi Jarjanazi ◽  
Hong Li ◽  
Lillian Sung ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Meta Analysis ◽  
Tissue Specific ◽  
Specific Cancer

scholarly journals Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3194
Author(s):  
Daniela Iannazzo ◽  
Claudia Espro ◽  
Consuelo Celesti ◽  
Angelo Ferlazzo ◽  
Giovanni Neri
Keyword(s):  
Quantum Dots ◽  
Treatment Success ◽  
Graphene Quantum Dots ◽  
Cancer Biomarkers ◽  
Great Promise ◽  
Sensing Platform ◽  
Specific Cancer ◽  
Diagnosis Of Cancer ◽  
Effective Diagnosis ◽  
Unique Chemical

The timely diagnosis of cancer represents the best chance to increase treatment success and to reduce cancer deaths. Nanomaterials-based biosensors containing graphene quantum dots (GQDs) as a sensing platform show great promise in the early and sensitive detection of cancer biomarkers, due to their unique chemical and physical properties, large surface area and ease of functionalization with different biomolecules able to recognize relevant cancer biomarkers. In this review, we report different advanced strategies for the synthesis and functionalization of GQDs with different agents able to selectively recognize and convert into a signal specific cancer biomarkers such as antigens, enzymes, hormones, proteins, cancer related byproducts, biomolecules exposed on the surface of cancer cells and changes in pH. The developed optical, electrochemical and chemiluminescent biosensors based on GQDs have been shown to ensure the effective diagnosis of several cancer diseases as well as the possibility to evaluate the effectiveness of anticancer therapy. The wide linear range of detection and low detection limits recorded for most of the reported biosensors highlight their great potential in clinics for the diagnosis and management of cancer.

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