scholarly journals STAT3 and STAT5A are potential therapeutic targets in castration-resistant prostate cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (49) ◽  
pp. 85997-86010 ◽  
Author(s):  
Sambit K. Mohanty ◽  
Kader Yagiz ◽  
Dinesh Pradhan ◽  
Daniel J. Luthringer ◽  
Mahul B. Amin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Targets ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant

scholarly journals ZBTB46, SPDEF, and ETV6: Novel Potential Biomarkers and Therapeutic Targets in Castration-Resistant Prostate Cancer

2019 ◽  
Vol 20 (11) ◽  
pp. 2802 ◽  
Author(s):  
AbdulFattah Salah Fararjeh ◽  
Yen-Nien Liu
Keyword(s):  
Prostate Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Kinase Inhibitor ◽  
Therapeutic Targets ◽  
Growth Factor Receptor ◽  
Castration Resistant Prostate Cancer ◽  
Mesenchymal Transition ◽  
Castration Resistant ◽  
Therapeutic Regime ◽  
Potential Biomarkers

Prostate cancer (PCa) is the second most common killer among men in Western countries. Targeting androgen receptor (AR) signaling by androgen deprivation therapy (ADT) is the current therapeutic regime for patients newly diagnosed with metastatic PCa. However, most patients relapse and become resistant to ADT, leading to metastatic castration-resistant PCa (CRPC) and eventually death. Several proposed mechanisms have been proposed for CRPC; however, the exact mechanism through which CRPC develops is still unclear. One possible pathway is that the AR remains active in CRPC cases. Therefore, understanding AR signaling networks as primary PCa changes into metastatic CRPC is key to developing future biomarkers and therapeutic strategies for PCa and CRPC. In the current review, we focused on three novel biomarkers (ZBTB46, SPDEF, and ETV6) that were demonstrated to play critical roles in CRPC progression, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) drug resistance, and the epithelial-to-mesenchymal transition (EMT) for patients treated with ADT or AR inhibition. In addition, we summarize how these potential biomarkers can be used in the clinic for diagnosis and as therapeutic targets of PCa.

Abstract 5707: STAT3 and STAT5a are potential therapeutic targets in castration-resistant prostate cancer

2017 ◽  
Author(s):  
Sambit K. Mohanty ◽  
Kader Yagiz ◽  
Luthringer Luthringer ◽  
Mahul B. Amin ◽  
Serhan Alkan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Targets ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant
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