scholarly journals Inhibition of endoplasmic reticulum stress alleviates cigarette smoke-induced airway inflammation and emphysema

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 77685-77695 ◽  
Author(s):  
Yong Wang ◽  
Zhen-Zhen Wu ◽  
Wei Wang
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Airway Inflammation ◽  
Cigarette Smoke

scholarly journals Endoplasmic reticulum stress in lung disease

2017 ◽  
Vol 26 (144) ◽  
pp. 170018 ◽  
Author(s):  
Stefan J. Marciniak
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Folding ◽  
Pulmonary Fibrosis ◽  
Endoplasmic Reticulum Stress ◽  
Lung Disease ◽  
Cigarette Smoke ◽  
Protein Misfolding ◽  
Fine Particulates ◽  
Disease Protein

Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease.

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