scholarly journals The farnesoid X receptor negatively regulates osteoclastogenesis in bone remodeling and pathological bone loss

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 76558-76573 ◽  
Author(s):  
Ting Zheng ◽  
Ju-Hee Kang ◽  
Jung-Sun Sim ◽  
Jung-Woo Kim ◽  
Jeong-Tae Koh ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Remodeling ◽  
Farnesoid X Receptor

BMP9 Prevents Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling

2019 ◽  
Author(s):  
Yan-man Zhou ◽  
Yu-ying Yang ◽  
Yi-xuan Jing ◽  
Tian-jiao Yuan ◽  
Li-hao Sun ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Remodeling ◽  
Ovariectomized Mice

Zanthoxylum piperitum reversed alveolar bone loss of periodontitis via regulation of bone remodeling-related factors

2017 ◽  
Vol 195 ◽  
pp. 137-142 ◽  
Author(s):  
Mi Hye Kim ◽  
Hye Ji Lee ◽  
Jung-Chul Park ◽  
Jongki Hong ◽  
Woong Mo Yang
Keyword(s):  
Bone Loss ◽  
Bone Remodeling ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Related Factors ◽  
Zanthoxylum Piperitum

scholarly journals The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Mengge Sun ◽  
Xiaoya Zhou ◽  
Lili Chen ◽  
Shishu Huang ◽  
Victor Leung ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Bone Loss ◽  
Bone Remodeling ◽  
Expression Profiles ◽  
Pathological Process ◽  
Cancer Development ◽  
Tissue Formation ◽  
Research Groups ◽  
Novel Biomarkers ◽  
Serum Micrornas

MicroRNAs are involved in many cellular and molecular activities and played important roles in many biological and pathological processes, such as tissue formation, cancer development, diabetes, neurodegenerative diseases, and cardiovascular diseases. Recently, it has been reported that microRNAs can modulate the differentiation and activities of osteoblasts and osteoclasts, the key cells that are involved in bone remodeling process. Meanwhile, the results from our and other research groups showed that the expression profiles of microRNAs in the serum and bone tissues are significantly different in postmenopausal women with or without fractures compared to the control. Therefore, it can be postulated that microRNAs might play important roles in bone remodeling and that they are very likely to be involved in the pathological process of postmenopausal osteoporosis. In this review, we will present the updated research on the regulatory roles of microRNAs in osteoblasts and osteoclasts and the expression profiles of microRNAs in osteoporosis and osteoporotic fracture patients. The perspective of serum microRNAs as novel biomarkers in bone loss disorders such as osteoporosis has also been discussed.

scholarly journals BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling

2020 ◽  
Vol 35 (5) ◽  
pp. 978-993 ◽  
Author(s):  
Yan‐Man Zhou ◽  
Yu‐Ying Yang ◽  
Yi‐Xuan Jing ◽  
Tian‐Jiao Yuan ◽  
Li‐Hao Sun ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Remodeling ◽  
Ovariectomized Mice

scholarly journals Serum Levels of miR-148a and miR-21-5p Are Increased in Type 1 Diabetic Patients and Correlated with Markers of Bone Strength and Metabolism

2018 ◽  
Vol 4 (4) ◽  
pp. 37 ◽  
Author(s):  
Giuseppina E. Grieco ◽  
Dorica Cataldo ◽  
Elena Ceccarelli ◽  
Laura Nigi ◽  
Giovanna Catalano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Bone Loss ◽  
Bone Metabolism ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Bone Fragility ◽  
Bone Homeostasis ◽  
Mineral Density

Type 1 diabetes (T1D) is characterized by bone loss and altered bone remodeling, resulting into reduction of bone mineral density (BMD) and increased risk of fractures. Identification of specific biomarkers and/or causative factors of diabetic bone fragility is of fundamental importance for an early detection of such alterations and to envisage appropriate therapeutic interventions. MicroRNAs (miRNAs) are small non-coding RNAs which negatively regulate genes expression. Of note, miRNAs can be secreted in biological fluids through their association with different cellular components and, in such context, they may represent both candidate biomarkers and/or mediators of bone metabolism alterations. Here, we aimed at identifying miRNAs differentially expressed in serum of T1D patients and potentially involved in bone loss in type 1 diabetes. We selected six miRNAs previously associated with T1D and bone metabolism: miR-21; miR-24; miR-27a; miR-148a; miR-214; and miR-375. Selected miRNAs were analyzed in sera of 15 T1D patients (age: 33.57 ± 8.17; BMI: 21.4 ± 1.65) and 14 non-diabetic subjects (age: 31.7 ± 8.2; BMI: 24.6 ± 4.34). Calcium, osteocalcin, parathormone (PTH), bone ALkaline Phoshatase (bALP), and Vitamin D (VitD) as well as main parameters of bone health were measured in each patient. We observed an increased expression of miR-148a (p = 0.012) and miR-21-5p (p = 0.034) in sera of T1D patients vs non-diabetic subjects. The correlation analysis between miRNAs expression and the main parameters of bone metabolism, showed a correlation between miR-148a and Bone Mineral Density (BMD) total body (TB) values (p = 0.042) and PTH circulating levels (p = 0.033) and the association of miR-21-5p to Bone Mineral Content-Femur (BMC-FEM). Finally, miR-148a and miR-21-5p target genes prediction analysis revealed several factors involved in bone development and remodeling, such as MAFB, WNT1, TGFB2, STAT3, or PDCD4, and the co-modulation of common pathways involved in bone homeostasis thus potentially assigning a role to both miR-148a and miR-21-5p in bone metabolism alterations. In conclusion, these results lead us to hypothesize a potential role for miR-148a and miR-21-5p in bone remodeling, thus representing potential biomarkers of bone fragility in T1D.

BONE CELLS UNDER MICROGRAVITY

2013 ◽  
Vol 13 (05) ◽  
pp. 1340006 ◽  
Author(s):  
PENG SHANG ◽  
JIAN ZHANG ◽  
AIRONG QIAN ◽  
JINGBAO LI ◽  
RUI MENG ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Loss ◽  
Bone Remodeling ◽  
Bone Cells ◽  
Microgravity Environment ◽  
Human Beings ◽  
Bone Mesenchymal Stem Cells ◽  
Skeleton Structure

Weightlessness environment (also microgravity) during the exploration of space is the major condition which must be faced by astronauts. One of the most serious adverse effects on astronauts is the weightlessness-induced bone loss due to the unbalanced bone remodeling. Bone remodeling of human beings has evolved during billions of years to make bone tissue adapt to the gravitational field of Earth (1g) and maintain skeleton structure to meet mechanical loading on Earth. However, under weightlessness environment the skeleton system no longer functions against the pull of gravity, so there is no necessity to keep bone strong enough to support the body's weight. Therefore, the balance of bone remodeling is disrupted and bone loss occurs, which is extremely deleterious to an astronaut's health during long-term spaceflight. Bone remodeling is mainly orchestrated by bone mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts. Here, we review how these bone cells respond to microgravity environment.

1,25-Dihydroxyvitamin D3 Corrects Bone Loss But Suppresses Bone Remodeling in Ovariohysterectomized Beagle Dogs*

Endocrinology ◽  
1988 ◽  
Vol 122 (5) ◽  
pp. 1998-2006 ◽  
Author(s):  
HARTMUT H. MALLUCHE ◽  
MARIE-CLAUDE FAUGERE ◽  
ROBERT M. FRIEDLER ◽  
PAOLO FANTI
Keyword(s):  
Bone Loss ◽  
Bone Remodeling ◽  
Beagle Dogs ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone Remodeling*

1989 ◽  
Vol 69 (3) ◽  
pp. 523-527 ◽  
Author(s):  
JAN J. ŠTĚPÁN ◽  
MILOŠ LACHMAN ◽  
JAN ZVĚŘINA ◽  
VLADÍMIR PACOVSKÝ ◽  
DAVID J. BAYLINK
Keyword(s):  
Bone Loss ◽  
Bone Remodeling ◽  
Calcitonin Treatment ◽  
Biochemical Indices ◽  
Loss Effect
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