scholarly journals Recombinant viral capsid protein VP1 suppresses lung cancer metastasis by inhibiting COX-2/PGE2 and MIG-7

Oncotarget ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 3931-3943 ◽  
Author(s):  
Ming-Yi Ho ◽  
Shao-Wen Hung ◽  
Chi-Ming Liang ◽  
Shu-Mei Liang
Keyword(s):  
Lung Cancer ◽  
Capsid Protein ◽  
Cancer Metastasis ◽  
Viral Capsid ◽  
Viral Capsid Protein ◽  
Lung Cancer Metastasis ◽  
Cox 2 ◽  
Capsid Protein Vp1

scholarly journals Retraction: MIG-7 Controls COX-2/PGE2-Mediated Lung Cancer Metastasis

2019 ◽  
Vol 79 (17) ◽  
pp. 4553-4553
Author(s):  
Ming-Yi Ho ◽  
Shu-Mei Liang ◽  
Shao-Wen Hung ◽  
Chi-Ming Liang
Keyword(s):  
Lung Cancer ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis ◽  
Cox 2

Binding of SV40’s Viral Capsid Protein VP1 to Its Glycosphingolipid Receptor GM1 Induces Negative Membrane Curvature: A Molecular Dynamics Study

Langmuir ◽  
2019 ◽  
Vol 35 (9) ◽  
pp. 3534-3544 ◽  
Author(s):  
Raisa Kociurzynski ◽  
Sophie D. Beck ◽  
Jean-Baptiste Bouhon ◽  
Winfried Römer ◽  
Volker Knecht
Keyword(s):  
Molecular Dynamics ◽  
Capsid Protein ◽  
Membrane Curvature ◽  
Viral Capsid ◽  
Viral Capsid Protein ◽  
Capsid Protein Vp1

scholarly journals MIG-7 Controls COX-2/PGE2-Mediated Lung Cancer Metastasis

2012 ◽  
Vol 73 (1) ◽  
pp. 439-449 ◽  
Author(s):  
Ming-Yi Ho ◽  
Shu-Mei Liang ◽  
Shao-Wen Hung ◽  
Chi-Ming Liang
Keyword(s):  
Lung Cancer ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis ◽  
Cox 2

scholarly journals Population Genomics of GII.4 Noroviruses Reveal Complex Diversification and New Antigenic Sites Involved in the Emergence of Pandemic Strains

2019 ◽  
Author(s):  
Kentaro Tohma ◽  
Cara J. Lepore ◽  
Yamei Gao ◽  
Lauren A. Ford-Siltz ◽  
Gabriel I. Parra
Keyword(s):  
Amino Acid ◽  
Capsid Protein ◽  
Large Scale ◽  
Population Genomics ◽  
Viral Capsid ◽  
Viral Gastroenteritis ◽  
Viral Capsid Protein ◽  
Antigenic Sites ◽  
Capsid Protein Vp1

AbstractGII.4 noroviruses are a major cause of acute gastroenteritis. Their dominance has been partially explained by the continuous emergence of antigenically distinct variants. To gain insights on the mechanisms of viral emergence and population dynamics of GII.4 noroviruses, we performed large-scale genomics, structural, and mutational analyses of the viral capsid protein (VP1). GII.4 noroviruses exhibited a periodic replacement of predominant variants with accumulation of amino acid substitutions. Genomic analyses revealed (i) a large number (87%) of conserved residues; (ii) variable residues that map on the previously determined antigenic sites; and (iii) variable residues that map outside of the antigenic sites. Residues from the third pattern formed motifs on the surface of VP1, which suggested extensions of previously predicted and new uncharacterized antigenic sites. The role of two motifs (C and G) in the antigenic make-up of the GII.4 capsid protein was confirmed with monoclonal antibodies and carbohydrate blocking assays. Amino acid profiles from antigenic sites (A, C, D, E, and G) correlated with the circulation patterns of GII.4 variants, with two of them (C and G) containing residues (352, 357, 378) linked with the emergence of new GII.4 variants. Notably, the emergence of each variant was followed by a stochastic diversification with minimal changes at the antigenic sites that did not progress towards the next variant. This study provides a methodological framework for antigenic characterization of viruses, and expands our understanding of the dynamics of GII.4 noroviruses that could facilitate the design of cross-reactive vaccines.ImportanceNoroviruses are an important cause of viral gastroenteritis around the world. An obstacle delaying the development of norovirus vaccines is an inadequate understanding of the role of norovirus diversity in immunity. Using a population genomics approach, we identified new residues on the viral capsid protein (VP1) from GII.4 noroviruses, the predominant genotype, that appear to be involved in the emergence and antigenic topology of GII.4 variants. Careful monitoring of the substitutions in those residues involved in the diversification and emergence of new viruses could help in the early detection of future novel variants with pandemic potential. Therefore, this novel information on the antigenic diversification could facilitate GII.4 norovirus vaccine design.

scholarly journals Population Genomics of GII.4 Noroviruses Reveal Complex Diversification and New Antigenic Sites Involved in the Emergence of Pandemic Strains

mBio ◽  
2019 ◽  
Vol 10 (5) ◽  
Author(s):  
Kentaro Tohma ◽  
Cara J. Lepore ◽  
Yamei Gao ◽  
Lauren A. Ford-Siltz ◽  
Gabriel I. Parra
Keyword(s):  
Amino Acid ◽  
Capsid Protein ◽  
Large Scale ◽  
Population Genomics ◽  
Viral Capsid ◽  
Viral Gastroenteritis ◽  
Viral Capsid Protein ◽  
Antigenic Sites ◽  
Capsid Protein Vp1

ABSTRACT GII.4 noroviruses are a major cause of acute gastroenteritis. Their dominance has been partially explained by the continuous emergence of antigenically distinct variants. To gain insights into the mechanisms of viral emergence and population dynamics of GII.4 noroviruses, we performed large-scale genomics, structural, and mutational analyses of the viral capsid protein (VP1). GII.4 noroviruses exhibited a periodic replacement of predominant variants with accumulation of amino acid substitutions. Genomic analyses revealed (i) a large proportion (87%) of conserved residues; (ii) variable residues that map on the previously determined antigenic sites; and (iii) variable residues that map outside the antigenic sites. Residues in the third pattern category formed motifs on the surface of VP1, which suggested extensions of previously predicted and new uncharacterized antigenic sites. The role of two motifs (C and G) in the antigenic makeup of the GII.4 capsid protein was confirmed with monoclonal antibodies and carbohydrate blocking assays. Amino acid profiles from antigenic sites (A, C, D, E, and G) correlated with the circulation patterns of GII.4 variants, with three of them (A, C, and G) containing residues (352, 357, 368, and 378) linked with the diversifying selective pressure on the emergence of new GII.4 variants. Notably, the emergence of each variant was followed by stochastic diversification with minimal changes that did not progress toward the next variant. This report provides a methodological framework for antigenic characterization of viruses and expands our understanding of the dynamics of GII.4 noroviruses and could facilitate the design of cross-reactive vaccines. IMPORTANCE Noroviruses are an important cause of viral gastroenteritis around the world. An obstacle delaying the development of norovirus vaccines is inadequate understanding of the role of norovirus diversity in immunity. Using a population genomics approach, we identified new residues on the viral capsid protein (VP1) from GII.4 noroviruses, the predominant genotype, that appear to be involved in the emergence and antigenic topology of GII.4 variants. Careful monitoring of the substitutions in those residues involved in the diversification and emergence of new viruses could help in the early detection of future novel variants with pandemic potential. Therefore, this novel information on the antigenic diversification could facilitate GII.4 norovirus vaccine design.

Wound Healing after Trauma May Predispose to Lung Cancer Metastasis

2011 ◽  
Vol 44 (5) ◽  
pp. 591-596 ◽  
Author(s):  
Nicholas D. Walter ◽  
Pamela L. Rice ◽  
Elizabeth F. Redente ◽  
Emily F. Kauvar ◽  
Lisa Lemond ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Wound Healing ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis

scholarly journals FlowCell-enriched circulating tumor cells as a predictor of lung cancer metastasis

Human Cell ◽  
2021 ◽  
Author(s):  
Yan Lu ◽  
Yushuang Zheng ◽  
Yuhong Wang ◽  
Dongmei Gu ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Metastasis ◽  
Lung Tumor ◽  
Early Stage ◽  
High Rate ◽  
Early Stage Lung Cancer ◽  
Lung Cancer Metastasis ◽  
Number Of Patients

AbstractLung cancer is the most fetal malignancy due to the high rate of metastasis and recurrence after treatment. A considerable number of patients with early-stage lung cancer relapse due to overlooked distant metastasis. Circulating tumor cells (CTCs) are tumor cells in blood circulation that originated from primary or metastatic sites, and it has been shown that CTCs are critical for metastasis and prognosis in various type of cancers. Here, we employed novel method to capture, isolate and classify CTC with FlowCell system and analyzed the CTCs from a cohort of 302 individuals. Our results illustrated that FlowCell-enriched CTCs effectively differentiated benign and malignant lung tumor and the total CTC counts increased as the tumor developed. More importantly, we showed that CTCs displayed superior sensitivity and specificity to predict lung cancer metastasis in comparison to conventional circulating biomarkers. Taken together, our data suggested CTCs can be used to assist the diagnosis of lung cancer as well as predict lung cancer metastasis. These findings provide an alternative means to screen early-stage metastasis.

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