scholarly journals Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy

Oncotarget ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 1602-1616 ◽  
Author(s):  
Janice M. Santiago-O’Farrill ◽  
Eugenie S. Kleinerman ◽  
Mario G. Hollomon ◽  
Andrew Livingston ◽  
Wei-Lien Wang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Response To Therapy ◽  
Potential Biomarker

Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes

2015 ◽  
Vol 158 (3) ◽  
pp. 377-379 ◽  
Author(s):  
N. V. Ryazantseva ◽  
E. A. Stepovaya ◽  
O. L. Nosareva ◽  
E. V. Konovalova ◽  
D. S. Orlov ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Heat Shock Protein 27 ◽  
Glutathione System ◽  
Blood Lymphocytes

scholarly journals Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment ?

2019 ◽  
Author(s):  
Seul-Ki Choi ◽  
Heejin Kam ◽  
Kye-Young Kim ◽  
Suk In Park ◽  
Yun-Sil Lee
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Treatment ◽  
Poor Prognosis ◽  
Treatment Resistance ◽  
Therapeutic Agents ◽  
Heat Shock Protein 27 ◽  
Cytoskeletal Remodeling ◽  
Protein Chaperone

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-dimensional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a major role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with poor prognosis, as well as treatment resistance whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as strategies for using HSP27 inhibitors for therapeutic purposes.

scholarly journals Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.

1996 ◽  
Vol 10 (11) ◽  
pp. 1371-1378 ◽  
Author(s):  
W Porter ◽  
F Wang ◽  
W Wang ◽  
R Duan ◽  
S Safe
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27

The Role of heat shock protein 27 in extravillous trophoblast differentiation

2008 ◽  
Vol 103 (3) ◽  
pp. 719-729 ◽  
Author(s):  
S. Tartakover Matalon ◽  
L. Drucker ◽  
A. Fishman ◽  
A. Ornoy ◽  
M. Lishner
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Extravillous Trophoblast ◽  
Trophoblast Differentiation

Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?

Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1051-1056 ◽  
Author(s):  
M. Zhao ◽  
J. X. Ding ◽  
K. Zeng ◽  
J. Zhao ◽  
F. Shen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Epithelial Ovarian Cancer ◽  
Peritoneal Metastasis ◽  
Heat Shock Protein 27 ◽  
Potential Biomarker

scholarly journals Plasma Concentration of Heat Shock Protein 27 and Risk of Cardiovascular Disease: A Prospective, Nested Case-Control Study

2008 ◽  
Vol 54 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Isabella Kardys ◽  
Nader Rifai ◽  
Olivier Meilhac ◽  
Jean-Baptiste Michel ◽  
Jose Luis Martin-Ventura ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Plasma Concentration ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cardiovascular Events ◽  
Conditional Logistic Regression ◽  
Plasma Concentrations ◽  
Heat Shock Protein 27 ◽  
Health Study ◽  
Potential Biomarker

Abstract Background: Heat shock protein 27 (HSP27) has been hypothesized to be a potential biomarker of atherothrombosis. However, no prospective studies have yet been performed to investigate the association between HSP27 plasma concentration and incident cardiovascular events among initially healthy individuals. Methods: We evaluated plasma concentrations of HSP27 at baseline among 255 initially healthy participants in the Women’s Health Study who subsequently developed myocardial infarction, ischemic stroke, or cardiovascular death during a follow-up period of up to 5.9 years and among an equal number of women matched for age and smoking but who remained free of cardiovascular disease over the same time period. Results: Overall, HSP27 plasma concentrations were inversely associated with age (Spearman correlation coefficient r = −0.258, P <0.001), but not with other established cardiovascular risk factors. Conditional logistic regression analysis showed no significant association of baseline HSP27 plasma concentration with future cardiovascular disease; the odds ratio for upper vs lower tertile of HSP27 concentration at baseline was 0.99 (95% CI 0.62–1.57, P for trend = 0.99). Conclusion: In this prospective study of initially healthy women, baseline HSP27 plasma concentration was not associated with incident cardiovascular events.

scholarly journals Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1195 ◽  
Author(s):  
Choi ◽  
Kam ◽  
Kim ◽  
Park ◽  
Lee
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Poor Prognosis ◽  
Treatment Resistance ◽  
Therapeutic Agents ◽  
Heat Shock Protein 27 ◽  
Functional Protein ◽  
Cytoskeletal Remodeling ◽  
Protein Chaperone

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.

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