scholarly journals miR-21 modulates the effect of EZH2 on the biological behavior of human lung cancer stem cells in vitro

Oncotarget ◽  
2017 ◽  
Vol 8 (49) ◽  
pp. 85442-85451 ◽  
Author(s):  
Hui Xia ◽  
Wen Zhang ◽  
Baoshi Zhang ◽  
Yingnan Zhao ◽  
Yunlong Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Lung ◽  
Biological Behavior ◽  
Human Lung Cancer ◽  
Lung Cancer Stem Cells

Abstract A30: Radiation resistance of human lung cancer stem cells (CSCs)

2012 ◽  
Vol 18 (3 Supplement) ◽  
pp. A30-A30
Author(s):  
Roberto Gomez-Casal ◽  
Simul Parikh ◽  
Roje Saleet ◽  
Per Basse ◽  
Michael K. Gibson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Radiation Resistance ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Stem Cells

scholarly journals Drug-Selected Human Lung Cancer Stem Cells: Cytokine Network, Tumorigenic and Metastatic Properties

PLoS ONE ◽  
2008 ◽  
Vol 3 (8) ◽  
pp. e3077 ◽  
Author(s):  
Vera Levina ◽  
Adele M. Marrangoni ◽  
Richard DeMarco ◽  
Elieser Gorelik ◽  
Anna E. Lokshin
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cytokine Network ◽  
Lung Cancer Stem Cells

scholarly journals Elimination of Human Lung Cancer Stem Cells through Targeting of the Stem Cell Factor–c-kit Autocrine Signaling Loop

2009 ◽  
Vol 70 (1) ◽  
pp. 338-346 ◽  
Author(s):  
Vera Levina ◽  
Adele Marrangoni ◽  
Tingting Wang ◽  
Simul Parikh ◽  
Yunyun Su ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Stem Cell Factor ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Autocrine Signaling ◽  
Lung Cancer Stem Cells ◽  
Factor C

scholarly journals Combination of Sasa quelpaertensis Nakai Leaf Extract and Cisplatin Suppresses the Cancer Stemness and Invasion of Human Lung Cancer Cells

2014 ◽  
Vol 13 (6) ◽  
pp. 529-540 ◽  
Author(s):  
Mina Kim ◽  
Yoo-Sun Kim ◽  
Kyung-Mi Kim ◽  
Hee-Chul Ko ◽  
Se-Jae Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Stem Cell Markers ◽  
Cancer Stemness ◽  
Human Lung Cancer Cells

Lung cancer is the leading cause of cancer death worldwide, and most chemotherapeutic drugs have limited success in treating this disease. Furthermore, some drugs show undesirable side effects due to the enrichment of cancer stem cells (CSCs) that are present, leading to resistance to conventional chemotherapy and tumor relapse. CSCs possess self-renewal characteristics, aggressive tumor initiating activity, and ability to facilitate tumor metastasis. Therefore, development of nontoxic agents that can potentiate chemotherapy and eliminate CSCs would be highly desirable. In the present study, we investigated whether Sasa quelpaertensis leaf extracts (SQE) and cisplatin (CIS), individually or in combination, would exert anti-CSC and antimetastatic effect in H1299 and A549 human lung cancer cells. Following these treatments, cell growth, phosphorylation of phosphoinositide-3 kinase, and activation of the mammalian target of rapamycin were inhibited. Decreased serial sphere formation, clonogenicity, and expression of major stem cell markers, such as CD44 and SOX-2, in CD44+ cancer stem cells were also observed. In addition, inhibition of cell migration and invasion in both cell lines as well as inhibition of matrix metalloproteinase-2 activity and expression were detected. Importantly, the anticancer stemness and antimetastasis effects in each of these assays were greater for the combined treatment with SQE and CIS than with each treatment individually. In conclusion, the data suggest that SQE alone, or in combination with CIS, represents a promising therapeutic strategy for eliminating cancer stemness and cell invasion potential of CSCs, thereby treating and preventing metastatic lung cancer cells.

scholarly journals Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells

2017 ◽  
Vol 37 (4) ◽  
pp. 2161-2166 ◽  
Author(s):  
Chang-Ying Guo ◽  
Chen Yan ◽  
Lan Luo ◽  
Shinji Goto ◽  
Yoshishige Urata ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Human Lung ◽  
Biological Properties ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Enhanced Expression
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