scholarly journals Age-associated and therapy-induced alterations in the cellular microenvironment of experimental gliomas

Oncotarget ◽  
2017 ◽  
Vol 8 (50) ◽  
pp. 87124-87135 ◽  
Author(s):  
Hannah Schneider ◽  
Birthe Lohmann ◽  
Hans-Georg Wirsching ◽  
Kathy Hasenbach ◽  
Elisabeth J. Rushing ◽  
...  
Keyword(s):  
Cellular Microenvironment ◽  
Experimental Gliomas

Multi-modal molecular imaging of anti-angiogenic treatment strategies of experimental gliomas

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
T. Viel ◽  
P. Boehm-Sturm ◽  
P. Monfared ◽  
S. Schäfers ◽  
G. Schneider ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Treatment Strategies ◽  
Experimental Gliomas

MR imaging of phagocytosis in experimental gliomas.

Radiology ◽  
1995 ◽  
Vol 197 (2) ◽  
pp. 533-538 ◽  
Author(s):  
C Zimmer ◽  
R Weissleder ◽  
K Poss ◽  
A Bogdanova ◽  
S C Wright ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Experimental Gliomas

scholarly journals Active Manipulation of ECM Stiffness

2011 ◽  
Author(s):  
Peter C. Y. Chen ◽  
Sahan C. B. Herath ◽  
Dong-an Wang ◽  
Kai Su ◽  
Kin Liao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Experimental Results ◽  
Environment Interaction ◽  
Cellular Microenvironment ◽  
Proliferation And Apoptosis ◽  
Scientific Principles ◽  
Extracellular Microenvironment

The mechanical properties of the microstructures surrounding cells influence the behavior of cells in differentiation, proliferation, and apoptosis, etc. The stiffness of the extra-cellular microenvironment has been shown to be one such mechanical property [1][2]. Studies reported in the literature concerning the stiffness of the extracellular microenvironment mainly sought to understand the scientific principles and mechanisms underlying its effect on cell-environment interaction [3]. This paper describes an approach that achieves such manipulation, and reports experimental results that demonstrate the effectiveness of this proposed approach.

scholarly journals Mechanics of the cellular microenvironment as perceived by cells in vivo

2021 ◽  
Author(s):  
Alessandro Mongera ◽  
Marie Pochitaloff ◽  
Hannah J. Gustafson ◽  
Georgina A. Stooke-Vaughan ◽  
Payam Rowghanian ◽  
...  
Keyword(s):  
Stress Relaxation ◽  
Mechanical Parameters ◽  
Cellular Microenvironment ◽  
Stem Cell Maintenance ◽  
Quantitative Studies ◽  
Cell Proliferation And Differentiation ◽  
3D Microenvironment ◽  
Proliferation And Differentiation

Tissue morphogenesis and repair, as well as organ homeostasis, require cells to constantly monitor their 3D microenvironment and adapt their behaviors in response to local biochemical and mechanical cues1-6. In vitro studies have shown that substrate stiffness and stress relaxation are important mechanical parameters in the control of cell proliferation and differentiation, stem cell maintenance, cell migration 7-11, as well as tumor progression and metastasis12,13. Yet, the mechanical parameters of the microenvironment that cells perceive in vivo, within 3D tissues, remain unknown. In complex materials with strain- and time-dependent material properties, the perceived mechanical parameters depend both on the strain and timescales at which the material is mechanically probed14. Here, we quantify in vivo and in situ the mechanics of the cellular microenvironment that cells probe during vertebrate presomitic mesoderm (PSM) specification. By analyzing the magnitude and dynamics of endogenous, cell-generated strains, we show that individual cells preferentially probe the stiffness associated with deformations of the supracellular, foam-like tissue architecture. We reveal how stress relaxation leads to a perceived microenvironment stiffness that decreases over time, with cells probing the softest regime. While stress relaxation timescales are spatially uniform in the tissue, most mechanical parameters, including those probed by cells, vary along the anteroposterior axis, as mesodermal progenitors commit to different lineages. Understanding the mechanical parameters that cells probe in their native 3D environment is important for quantitative studies of mechanosensation in vivo2-4,6,15 and can help design scaffolds for tissue engineering applications16-18.

scholarly journals A Disposable Photovoltaic Patch Controlling Cellular Microenvironment for Wound Healing

2018 ◽  
Vol 19 (10) ◽  
pp. 3025 ◽  
Author(s):  
Hyeon-Ki Jang ◽  
Jin Oh ◽  
Gun-Jae Jeong ◽  
Tae-Jin Lee ◽  
Gwang-Bum Im ◽  
...  
Keyword(s):  
Wound Healing ◽  
Large Scale ◽  
Healing Process ◽  
Skin Wound ◽  
Myoblast Differentiation ◽  
Wound Healing Process ◽  
Light Illumination ◽  
Cellular Microenvironment ◽  
Healing Processes

Electrical stimulation (ES) is known to affect the wound healing process by modulating skin cell behaviors. However, the conventional clinical devices that can generate ES for promoting wound healing require patient hospitalization due to large-scale of the extracorporeal devices. Herein, we introduce a disposable photovoltaic patch that can be applied to skin wound sites to control cellular microenvironment for promoting wound healing by generating ES. In vitro experiment results show that exogenous ES could enhance cell migration, proliferation, expression of extracellular matrix proteins, and myoblast differentiation of fibroblasts which are critical for wound healing. Our disposable photovoltaic patches were attached to the back of skin wound induced mice. Our patch successfully provided ES, generated by photovoltaic energy harvested from the organic solar cell under visible light illumination. In vivo experiment results show that the patch promoted cutaneous wound healing via enhanced host-inductive cell proliferation, cytokine secretion, and protein synthesis which is critical for wound healing process. Unlike the current treatments for wound healing that engage passive healing processes and often are unsuccessful, our wearable photovoltaic patch can stimulate regenerative activities of endogenous cells and actively contribute to the wound healing processes.

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