scholarly journals Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks

Oncotarget ◽  
2010 ◽  
Vol 1 (7) ◽  
pp. 606-619 ◽  
Author(s):  
Rachael Elizabeth Hawtin ◽  
David Elliot Stockett ◽  
Oi Kwan Wong ◽  
Cecilia Lundin ◽  
Thomas Helleday ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Double Strand Breaks ◽  
Homologous Recombination Repair ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Recombination Repair

scholarly journals Rad50 Is Not Essential for the Mre11-Dependent Repair of DNA Double-Strand Breaks in Halobacterium sp. Strain NRC-1

2008 ◽  
Vol 190 (15) ◽  
pp. 5210-5216 ◽  
Author(s):  
A. Kish ◽  
J. DiRuggiero
Keyword(s):  
Homologous Recombination ◽  
Double Strand Breaks ◽  
Homologous Recombination Repair ◽  
Dna Double Strand Breaks ◽  
Γ Radiation ◽  
Strand Breaks ◽  
Background Strain ◽  
Recombination Repair ◽  
Mutant Strains ◽  
Uv C

ABSTRACT The genome of the halophilic archaeon Halobacterium sp. strain NRC-1 encodes homologs of the eukaryotic Mre11 and Rad50 proteins, which are involved in the recognition and end processing of DNA double-strand breaks in the homologous recombination repair pathway. We have analyzed the phenotype of Halobacterium deletion mutants lacking mre11 and/or rad50 after exposure to UV-C radiation, an alkylating agent (N-methyl-N′-nitro-N-nitrosoguanidine), and γ radiation, none of which resulted in a decrease in survival of the mutant strains compared to that of the background strain. However, a decreased rate of repair of DNA double-strand breaks in strains lacking the mre11 gene was observed using pulsed-field gel electrophoresis. These observations led to the hypothesis that Mre11 is essential for the repair of DNA double-strand breaks in Halobacterium, whereas Rad50 is dispensable. This is the first identification of a Rad50-independent function for the Mre11 protein, and it represents a shift in the Archaea away from the eukaryotic model of homologous recombination repair of DNA double-strand breaks.

scholarly journals A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks

2018 ◽  
Vol 4 (9) ◽  
pp. 1201-1210 ◽  
Author(s):  
Bingbing X. Li ◽  
Jingjin Chen ◽  
Bo Chao ◽  
Yixian Zheng ◽  
Xiangshu Xiao
Keyword(s):  
Homologous Recombination ◽  
Double Strand Breaks ◽  
Homologous Recombination Repair ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Recombination Repair
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