scholarly journals Application of in vivo imaging techniques to monitor therapeutic efficiency of PLX4720 in an experimental model of microsatellite instable colorectal cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (41) ◽  
pp. 69756-69767 ◽  
Author(s):  
Sarah Rohde ◽  
Tobias Lindner ◽  
Stefan Polei ◽  
Jan Stenzel ◽  
Luise Borufka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Experimental Model ◽  
In Vivo Imaging ◽  
Imaging Techniques ◽  
Therapeutic Efficiency

scholarly journals In Vivo Imaging of Peripheral Benzodiazepine Receptors in Mouse Lungs: A Biomarker of Inflammation

2005 ◽  
Vol 4 (4) ◽  
pp. 7290.2005.05133 ◽  
Author(s):  
Matthew J. Hardwick ◽  
Ming-Kai Chen ◽  
Kwamena Baidoo ◽  
Martin G. Pomper ◽  
Tomás R. Guilarte
Keyword(s):  
In Vivo Imaging ◽  
Ex Vivo ◽  
Inflammatory Diseases ◽  
Imaging Techniques ◽  
Benzodiazepine Receptors ◽  
Small Animal ◽  
Small Animal Pet ◽  
Planar Imaging ◽  
Peripheral Benzodiazepine Receptors

The ability to visualize the immune response with radioligands targeted to immune cells will enhance our understanding of cellular responses in inflammatory diseases. Peripheral benzodiazepine receptors (PBR) are present in monocytes and neutrophils as well as in lung tissue. We used lipopolysaccharide (LPS) as a model of inflammation to assess whether the PBR could be used as a noninvasive marker of inflammation in the lungs. Planar imaging of mice administrated 10 or 30 mg/kg LPS showed increased [123I]-( R)-PK11195 radioactivity in the thorax 2 days after LPS treatment relative to control. Following imaging, lungs from control and LPS-treated mice were harvested for ex vivo gamma counting and showed significantly increased radioactivity above control levels. The specificity of the PBR response was determined using a blocking dose of nonradioactive PK11195 given 30 min prior to radiotracer injection. Static planar images of the thorax of nonradioactive PK11195 pretreated animals showed a significantly lower level of radiotracer accumulation in control and in LPS-treated animals ( p < .05). These data show that LPS induces specific increases in PBR ligand binding in the lungs. We also used in vivo small-animal PET studies to demonstrate increased [11C]-( R)-PK11195 accumulation in the lungs of LPS-treated mice. This study suggests that measuring PBR expression using in vivo imaging techniques may be a useful biomarker to image lung inflammation.

Novel in vivo imaging techniques for the liver microvasculature

IntraVital ◽  
2012 ◽  
Vol 1 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Mynthia Cabrera ◽  
Ute Frevert
Keyword(s):  
In Vivo Imaging ◽  
Imaging Techniques

scholarly journals In vivo imaging techniques: a new era for histochemical analysis

2016 ◽  
Author(s):  
A. Busato ◽  
P. Fumene Feruglio ◽  
P.P. Parnigotto ◽  
P. Marzola ◽  
A. Sbarbati
Keyword(s):  
Magnetic Resonance ◽  
In Vivo Imaging ◽  
Diffusion Tensor ◽  
Technological Development ◽  
Imaging Techniques ◽  
Resonance Spectroscopy ◽  
Preclinical Research ◽  
Tissue Contrast ◽  
Magnetic Resonance Imaging Mri

In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/preclinical research, has excellent anatomical resolution, unlimited penetration depth and intrinsic soft tissue contrast. Thanks to the technological development, MRI is not only capable to provide morphological information but also and more interestingly functional, biophysical and molecular. In this paper we describe the main features of several advanced imaging techniques, such as MRI microscopy, Magnetic Resonance Spectroscopy, functional MRI, Diffusion Tensor Imaging and MRI with contrast agent as a useful support to classical histochemistry.

In vitro and in vivo imaging techniques for cartilage tissue engineering

2006 ◽  
Vol 39 ◽  
pp. S447
Author(s):  
S. Tiwari ◽  
S. Pollok ◽  
H. Notbohm ◽  
R. Reis ◽  
B. Vollmar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
In Vivo Imaging ◽  
Imaging Techniques ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

Non-invasive Imaging Techniques: From Histology to In Vivo Imaging

2020 ◽  
pp. 795-812
Author(s):  
Thomas Bocklitz ◽  
Anja Silge ◽  
Hyeonsoo Bae ◽  
Marko Rodewald ◽  
Fisseha Bekele Legesse ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Imaging Techniques ◽  
Non Invasive

Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques

2016 ◽  
Vol 235 ◽  
pp. 352-364 ◽  
Author(s):  
Susanne Beyer ◽  
Li Xie ◽  
Mike Schmidt ◽  
Natasja de Bruin ◽  
Mukul Ashtikar ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Imaging Techniques ◽  
Prolonged Release

In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice

2012 ◽  
Vol 29 (6) ◽  
pp. 573-583 ◽  
Author(s):  
Andreas Pichorner ◽  
Ulrike Sack ◽  
Dennis Kobelt ◽  
Inken Kelch ◽  
Franziska Arlt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
In Vivo Imaging ◽  
Cancer Growth
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