scholarly journals Contrast-enhanced endoscopic ultrasound for differential diagnosis of pancreatic cancer: an updated meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (39) ◽  
pp. 66392-66401 ◽  
Author(s):  
Xing-Kang He ◽  
Yue Ding ◽  
Lei-Min Sun
Keyword(s):  
Pancreatic Cancer ◽  
Differential Diagnosis ◽  
Endoscopic Ultrasound ◽  
Meta Analysis ◽  
Contrast Enhanced

scholarly journals Contrast-enhanced endoscopic ultrasound for the differential diagnosis between benign and malignant lymph nodes: a meta-analysis

2019 ◽  
Vol 07 (04) ◽  
pp. E504-E513 ◽  
Author(s):  
Andrea Lisotti ◽  
Claudio Ricci ◽  
Marta Serrani ◽  
Claudio Calvanese ◽  
Sandro Sferrazza ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Likelihood Ratio ◽  
Endoscopic Ultrasound ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Diagnostic Odds Ratio ◽  
Significant Heterogeneity ◽  
Contrast Enhanced ◽  
Malignant Lymph Nodes

Abstract Background The differential diagnosis between benign and malignant lymph nodes (LNs) is crucial for patient management and clinical outcome. The use of contrast-enhanced endoscopic ultrasound (EUS) has been evaluated in several studies with diverse results. The aim of this meta-analysis was to evaluate the pooled diagnostic accuracy of contrast-enhanced EUS (CE-EUS) and contrast-enhanced harmonic EUS (CH-EUS) in this setting. Methods A systematic electronic search was performed, including all original papers dealing with assessment of the nature of the LNs using CE-EUS or CH-EUS. A meta-analysis was performed to obtain pooled sensitivity, specificity, positive and negative likelihood ratio, and diagnostic odds ratio. The Summary Receiver Operating Characteristic (ROC) Curve method was used to calculate the area under the curve. Statistical analysis was carried out using Meta-Disc V.1.4, Stata V.12.0 and Review Manager V.5.2. Results Among 210 pertinent studies, four (336 patients) were included in the analysis. The pooled sensitivity was 82.1 % (75.1 – 87.7 %) and pooled specificity was 90.7 % (85.9 – 94.3 %) with significant heterogeneity found in sensitivity; the positive-likelihood ratio (LR) was 7.77 (5.09 – 11.85) and the negative-LR was 0.15 (0.05 – 0.46); the pooled diagnostic odds ratio (DOR) was 54 (15 – 190). Subgroup analysis including studies performed using CH-EUS (two studies, 177 LNs) showed a pooled sensitivity of 87.7 % (77.0 – 93.9 %) and a pooled specificity of 91.8 % (84.5 % – 96.4 %) with no significant heterogeneity; the pooled positive-LR was 9.51 (4.95 – 18.28) and the pooled negative-LR was 0.14 (0.06 – 0.35); pooled DOR was 68.42 (15.5 – 301.4). Conclusions From these data, CE-EUS is not recommended due to inadequate sensitivity. On the other hand, CH-EUS studies showed optimal accuracy (pooled sensitivity 87.7 % and specificity 91.8 %), comparable to elastography and even EUS-guided fine needle aspiration (EUS-FNA), suggesting a role in the diagnostic algorithm.

Su1310 Contrast Enhanced Endoscopic Ultrasound in Differential Diagnosis between Autoimmune Pancreatitis and Pancreatic Cancer

2016 ◽  
Vol 83 (5) ◽  
pp. AB347
Author(s):  
Min Keun Cho ◽  
Tae Jun Song ◽  
Kwangwoo Nam ◽  
Dongwook Oh ◽  
Do Hyun Park ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Differential Diagnosis ◽  
Endoscopic Ultrasound ◽  
Autoimmune Pancreatitis ◽  
Contrast Enhanced

Contrast-Enhanced Power Doppler Endoscopic Ultrasound Used for the Differential Diagnosis of Chronic Pancreatitis and Pancreatic Cancer

2009 ◽  
Vol 69 (5) ◽  
pp. AB332 ◽  
Author(s):  
Adrian Saftoiu ◽  
Sevastita Iordache ◽  
Dan Ionut Gheonea ◽  
Monalisa Filip ◽  
Ana Maria Ioncica ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Differential Diagnosis ◽  
Chronic Pancreatitis ◽  
Endoscopic Ultrasound ◽  
Power Doppler ◽  
Contrast Enhanced

scholarly journals Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Michael Hocke ◽  
Christoph F. Dietrich
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Pancreatic Carcinoma ◽  
Endoscopic Ultrasound ◽  
Clinical Medicine ◽  
Pancreatic Tissue ◽  
Mechanical Index ◽  
Contrast Enhanced ◽  
Inflammatory Processes ◽  
Doppler Techniques

Discriminating between focal chronic pancreatitis and pancreatic cancer is always a challenge in clinical medicine. Contrast-enhanced endoscopic ultrasound using Doppler techniques can uniquely reveal different vascularisation patterns in pancreatic tissue alterated by chronic inflammatory processes and even allows a discrimination from pancreatic cancer. This paper will describe the basics of contrast-enhanced high mechanical index endoscopic ultrasound (CEHMI EUS) and contrast enhanced low mechanical index endoscopic ultrasound (CELMI EUS) and explain the pathophysiological differences of the vascularisation of chronic pancreatitis and pancreatic carcinoma. Furthermore it will discuss how to use these techniques in daily clinical practice.

Tu1344 VALUE OF CONTRAST-ENHANCED HARMONIC EUS WITH ENHANCEMENT PATTERN FOR DIAGNOSIS OF PANCREATIC CANCER: A META-ANALYSIS

2019 ◽  
Vol 89 (6) ◽  
pp. AB582 ◽  
Author(s):  
Yasunobu Yamashita ◽  
Toshio Shimokawa ◽  
Bertrand Napoleon ◽  
Pietro Fusaroli ◽  
Rodica Gincul ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Meta Analysis ◽  
Enhancement Pattern ◽  
Contrast Enhanced
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