scholarly journals Cancer antigen 15-3, platelet distribution width, and fibrinogen in combination to distinguish breast cancer from benign breast disease in non-conclusive mammography patients

Oncotarget ◽  
2017 ◽  
Vol 8 (40) ◽  
pp. 67829-67836 ◽  
Author(s):  
Shuang Fu ◽  
Zhi-Yuan Yun ◽  
Ming-Ming Cui ◽  
Hongxue Meng ◽  
Cheng Qian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Platelet Distribution Width ◽  
Cancer Antigen ◽  
Distribution Width

scholarly journals Serum levels of oxidative stress marker malondialdehyde in breast cancer patients in relation to pathohistological factors, estrogen receptors, menopausal status, and age

2018 ◽  
Vol 8 (3) ◽  
pp. 154-161
Author(s):  
Jasmina Gubaljevic ◽  
Nahida Srabović ◽  
Adlija Jevrić-Čaušević ◽  
Adaleta Softić ◽  
Adi Rifatbegović ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Benign Breast Disease ◽  
Menopausal Status ◽  
Serum Levels ◽  
Breast Disease ◽  
Breast Cancer Patients ◽  
Node Metastases

Introduction: The aim of this study was to determine the serum levels of malondialdehyde (MDA) in patients with invasive breast cancer in relation to its serum levels in patients with benign breast disease, and to investigate correlation between MDA serum levels with pathohistological prognostic factors (tumor size, lymph node involvement, and histologic grade [HG]), estrogen receptor (ER) status, and with breast cancer patient’s age and menopausal status. Methods: A total of 43 with well-documented invasive breast cancer were included in this study: 27 with positive axillary’s lymph nodes, and 16 with negative axillary’s lymph nodes, and 39 patients with findings of benign breast diseases. MDA determination in serum of breast cancer and benign breast disease patients was performed by the fluorimetric method, immunohistochemical staining was performed for ER, and routine pathohistological examination was conducted for pathohistological factors. Results: MDA serum levels in breast cancer patients were significantly higher than MDA serum levels in benign breast disease patients (p = 0.042). No statistically significant difference between MDA serum levels in breast cancer patients with and without lymph node metastases was found (p = 0.238). No statistically significant correlations between MDA serum levels and tumor size (p = 0.256), HG (p = 0.124), or number of positive lymph nodes (0.113) were found. A statistically significant correlation between serum MDA levels and ages of breast cancer patients with lymph node metastases was found (p = 0.006). Conclusion: Obtained results support the importance of MDA in the carcinogenesis of breast cancer. According to our findings, serum level of MDA could not be a useful prognostic factor in breast cancer.

scholarly journals The influence of family history on breast cancer risk in women with biopsy-confirmed benign breast disease

Cancer ◽  
2006 ◽  
Vol 107 (6) ◽  
pp. 1240-1247 ◽  
Author(s):  
Laura C. Collins ◽  
Heather J. Baer ◽  
Rulla M. Tamimi ◽  
James L. Connolly ◽  
Graham A. Colditz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Benign Breast Disease ◽  
Breast Disease

Benign breast disease

2010 ◽  
pp. 1940-1942
Author(s):  
P. Jane Clarke ◽  
R. Fiddes
Keyword(s):  
Breast Cancer ◽  
Clinical Examination ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Cystic Change ◽  
Cancer Symptoms ◽  
Triple Assessment ◽  
Pathological Assessment

Benign conditions of the breast are very common, but they cause great anxiety, often leading the patient to be concerned that she has breast cancer. Symptoms may include: (1) a mass in the breast, commonly due to fibroadenoma, benign cystic change, or macrocysts; (2) mastalgia; and (3) discharge from the nipple, which may be caused by hyperprolactinaemia, intraduct papilloma, or duct ectasia. Management involves exclusion of malignancy, often by triple assessment of any palpable abnormality (for clinical examination, radiological and pathological assessment, see ...

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