scholarly journals Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 63551-63561 ◽  
Author(s):  
Li Sun ◽  
Yajie Yin ◽  
Leslie H. Clark ◽  
Wenchuan Sun ◽  
Stephanie A. Sullivan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Strategy ◽  
Inhibition Of Glycolysis ◽  
Dual Inhibition

scholarly journals MiR-200c-3p Contrasts PD-L1 Induction by Combinatorial Therapies and Slows Proliferation of Epithelial Ovarian Cancer through Downregulation of β-Catenin and c-Myc

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 519
Author(s):  
Eleni Anastasiadou ◽  
Elena Messina ◽  
Tiziana Sanavia ◽  
Lucia Mundo ◽  
Federica Farinella ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Therapeutic Strategy ◽  
Target Genes ◽  
Ovarian Cancer Cells ◽  
Oncogenic Signaling ◽  
Experimental Conditions ◽  
Skov3 Cells ◽  
In Silico Analyses ◽  
Post Therapy

Conventional/targeted chemotherapies and ionizing radiation (IR) are being used both as monotherapies and in combination for the treatment of epithelial ovarian cancer (EOC). Several studies show that these therapies might favor oncogenic signaling and impede anti-tumor responses. MiR-200c is considered a master regulator of EOC-related oncogenes. In this study, we sought to investigate if chemotherapy and IR could influence the expression of miR-200c-3p and its target genes, like the immune checkpoint PD-L1 and other oncogenes in a cohort of EOC patients’ biopsies. Indeed, PD-L1 expression was induced, while miR-200c-3p was significantly reduced in these biopsies post-therapy. The effect of miR-200c-3p target genes was assessed in miR-200c transfected SKOV3 cells untreated and treated with olaparib and IR alone. Under all experimental conditions, miR-200c-3p concomitantly reduced PD-L1, c-Myc and β-catenin expression and sensitized ovarian cancer cells to olaparib and irradiation. In silico analyses further confirmed the anti-correlation between miR-200c-3p with c-Myc and β-catenin in 46 OC cell lines and showed that a higher miR-200c-3p expression associates with a less tumorigenic microenvironment. These findings provide new insights into how miR-200c-3p could be used to hold in check the adverse effects of conventional chemotherapy, targeted therapy and radiation therapy, and offer a novel therapeutic strategy for EOC.

γ-Interferon Gene Transfer as a Therapeutic Strategy for Ovarian Cancer

1998 ◽  
pp. 349-352 ◽  
Author(s):  
C. D’Incan ◽  
R. Sanches ◽  
M. Kuiper ◽  
F. Penault-Llorca ◽  
M. De Latour ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Transfer ◽  
Therapeutic Strategy ◽  
Interferon Gene ◽  
Γ Interferon

scholarly journals Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2+/− Mice

Neoplasia ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 230-238 ◽  
Author(s):  
Ashley T. Jones ◽  
Kalin Narov ◽  
Jian Yang ◽  
Julian R. Sampson ◽  
Ming Hong Shen
Keyword(s):  
Renal Lesions ◽  
Inhibition Of Glycolysis ◽  
Dual Inhibition
Sign in / Sign up

Export Citation Format

Share Document