scholarly journals Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming

Oncotarget ◽  
2017 ◽  
Vol 8 (40) ◽  
pp. 67639-67650 ◽  
Author(s):  
Haymanti Bhanot ◽  
Ellen L. Weisberg ◽  
Mamatha M. Reddy ◽  
Atsushi Nonami ◽  
Donna Neuberg ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cell Growth ◽  
Myeloid Leukemia ◽  
Metabolic Reprogramming ◽  
Leukemia Cells ◽  
Phosphogluconate Dehydrogenase ◽  
Acute Myeloid Leukemia Cells ◽  
Acute Myeloid

scholarly journals Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3325
Author(s):  
Ba Thi Cham ◽  
Nguyen Thi Thuy Linh ◽  
Do Thi Thao ◽  
Nguyen Thi Hoang Anh ◽  
Nguyen Thanh Tam ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Myeloid Leukemia ◽  
Cell Growth ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
G1 Phase ◽  
Cell Growth Inhibition ◽  
Acute Myeloid Leukemia Cells ◽  
Apoptotic Effects ◽  
Acute Myeloid

In previous studies, we isolated the known compound saponin XII from the roots of Dipsacus japonicus Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was associated with a significant increase of apoptosis and of cells in the G0/G1 phase of the cell cycle, with a decrease of cells in the S and G2/M phases. Thus, the inhibition of cell growth in OCI-AML3 cells was due to antiproliferative and pro-apoptotic effects. Interestingly, the bioactivity of saponin XII exerted its effect at a concentration as low as 1 µg/mL.

Effect of miR-128 in DNA Damage of HL-60 Acute Myeloid Leukemia Cells

2014 ◽  
Vol 15 (5) ◽  
pp. 492-502 ◽  
Author(s):  
Hugo Seca ◽  
Raquel Lima ◽  
Gabriela Almeida ◽  
Manuel Sobrinho-Simoes ◽  
Rui Bergantim ◽  
...  
Keyword(s):  
Dna Damage ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Acute Myeloid Leukemia Cells ◽  
Acute Myeloid
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