scholarly journals Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1

Oncotarget ◽  
2017 ◽  
Vol 8 (40) ◽  
pp. 66833-66848 ◽  
Author(s):  
Federica Ruffini ◽  
Lauretta Levati ◽  
Grazia Graziani ◽  
Simona Caporali ◽  
Maria Grazia Atzori ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Melanoma ◽  
Platelet Derived Growth Factor ◽  
Neuropilin 1 ◽  
Factor C

scholarly journals Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness

2013 ◽  
Vol 30 (6) ◽  
pp. 2887-2896 ◽  
Author(s):  
FEDERICA RUFFINI ◽  
LUCIO TENTORI ◽  
ANNALISA SUSANNA DORIO ◽  
DIEGO ARCELLI ◽  
GIULIA D’AMATI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Melanoma Cell ◽  
Human Melanoma ◽  
Platelet Derived Growth Factor ◽  
Human Melanoma Cell ◽  
Calpain 3 ◽  
Cell Invasiveness ◽  
Factor C

scholarly journals On-line hemodiafiltration modulates atherosclerosis signaling in peripheral lymphomonocytes of hemodialysis patients

2021 ◽  
Author(s):  
Simona Simone ◽  
Annarita Chieti ◽  
Paola Pontrelli ◽  
Federica Rascio ◽  
Giuseppe Castellano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Networks ◽  
Mononuclear Cells ◽  
Expression Profiles ◽  
Hemodialysis Patients ◽  
Monoamine Oxidase A ◽  
Platelet Derived Growth Factor ◽  
Peripheral Blood Mononuclear ◽  
On Line ◽  
Factor C

Abstract Background Hemodialysis patients present a dramatic increase in cardiovascular morbidity/mortality. Circulating immune cells, activated by both uremic milieu and dialysis, play a key role in the pathogenesis of dialysis-related vascular disease. The aim of our study was to identify, through a high-throughput approach, differences in gene expression profiles in the peripheral blood mononuclear cells (PBMCs) of patients treated with on-line hemodiafiltration and bicarbonate hemodialysis. Methods The transcriptomic profile was investigated in PBMCs isolated from eight patients on on-line hemodiafiltration and eight patients on bicarbonate hemodialysis by microarray analysis. The results were evaluated by statistical and functional pathway analysis and validated by real time PCR (qPCR) in an independent cohort of patients (on-line hemodiafiltration N = 20, bicarbonate hemodialysis n = 20). Results Eight hundred and forty-seven genes were differentially expressed in patients treated with  on-line hemodiafiltration and bicarbonate hemodialysis. Thirty-seven functional gene networks were identified and atherosclerosis signaling was the top canonical pathway regulated by on-line hemodiafiltration. Among the genes of this pathway, on-line hemodiafiltration was associated with a reduced expression of Platelet-derived growth factor A chain (PDGF A), Clusterin, Monoamine Oxidase A, Interleukin-6 (IL-6) and Vascular Endothelial Growth Factor C (VEGF-)C and with an increase of Apolipoprotein E. qPCR confirmed the microarray results. Platelet derived growth factor AA (PDGF-AA), IL-6 and VEGF-C serum levels were significantly lower in the on-line hemodiafiltration group. Finally, 10 patients previously on bicarbonate hemodialysis  were switched to on-line hemodiafiltration and PBMCs were harvested after 6 months. The qPCR results from this perspective group confirmed the modulation of atherosclerotic genes observed in the cross-sectional analysis. Conclusions Our data suggest that type of dialysis (on-line hemodiafiltration versus bicarbonate hemodialysis) may modulate the expression of several genes involved in the pathogenesis of atherosclerotic disease.

scholarly journals Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

2005 ◽  
Vol 102 (9) ◽  
pp. 3389-3394 ◽  
Author(s):  
J. S. Campbell ◽  
S. D. Hughes ◽  
D. G. Gilbertson ◽  
T. E. Palmer ◽  
M. S. Holdren ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Liver Fibrosis ◽  
Platelet Derived Growth Factor ◽  
Factor C

Platelet-Derived Growth Factor C in Alcoholics

2020 ◽  
Vol 55 (2) ◽  
pp. 157-163 ◽  
Author(s):  
C Martín-González ◽  
L González-Navarrete ◽  
I Ribot-Hernández ◽  
V Vera-Delgado ◽  
J Alvisa-Negrín ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Platelet Count ◽  
Growth Factor ◽  
Serum Levels ◽  
Muscle Disease ◽  
Platelet Derived Growth Factor ◽  
Laboratory Evaluation ◽  
Prothrombin Activity ◽  
Factor C ◽  
Factor Α

Abstract Aims Platelet-derived growth factor (PDGF) promotes liver collagen deposition, acting on hepatic stellate cells. Despite this, low serum PDGF levels were reported in chronic hepatitis C or B infection, although some studies yield the opposite result. Since PDGF may be related not only to fibrosis but also with vascular, neuronal or muscle disease, it is important to analyze its behavior in alcoholics. Methods In total, 17 controls and 62 alcoholic patients consecutively admitted to the hospitalization unit of the Internal Medicine Service were included. We determined serum levels of PDGF C, routine laboratory evaluation, tumor necrosis factor-α, interleukin (IL)-6 and IL-8 and malondialdehyde (MDA) levels. We analyzed the relationships between PDGF and liver function, ethanol intake and inflammatory reaction by both univariate and multivariate analysis to discern which variables PDGF levels depend on. Results Serum PDGF levels were significantly lower among patients (675 ± 466 pg/ml) than among controls (1074 ± 337 pg/ml; Z = 3.70; P < 0.001), and even lower among cirrhotics (549 ± 412 among cirrhotics vs 778 ± 487 among non-cirrhotics; Z = 2.33; P = 0.02). PDGF levels showed a direct correlation with prothrombin activity (ρ = 0.50; P < 0.001), platelet count (ρ = 0.44; P < 0.001) and inverse ones with bilirubin (ρ = −0.39; P = 0.002), IL-6 (ρ = −0.33; P = 0.016), IL-8 (ρ = −0.47; P < 0.001), and MDA levels (ρ = −0.44; P < 0.001). By multivariate analysis, only prothrombin activity and platelet count were independently related to PDGF. Conclusion PDGF-C levels are decreased in alcoholics, especially among cirrhotics. Multivariate analysis discloses that only prothrombin activity and platelet count are independently related to PDGF-C levels.

scholarly journals Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation

2014 ◽  
Vol 1842 (2) ◽  
pp. 318-325 ◽  
Author(s):  
Kimberly J. Riehle ◽  
Melissa M. Johnson ◽  
Fredrik Johansson ◽  
Renay L. Bauer ◽  
Brian J. Hayes ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasminogen Activator ◽  
Platelet Derived Growth Factor ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Factor C

Expression of platelet-derived growth factor-C in aqueous humor of patients with neovascular glaucoma and its correlation with vascular endothelial growth factor

2019 ◽  
Vol 30 (3) ◽  
pp. 500-505
Author(s):  
Yujie Li ◽  
Dan Hu ◽  
Peilin Lv ◽  
Minyan Xing ◽  
Zejuan Song ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Aqueous Humor ◽  
Neovascular Glaucoma ◽  
Platelet Derived Growth Factor ◽  
Vascular Endothelial ◽  
Iris Neovascularization ◽  
Factor C ◽  
Endothelial Growth Factor ◽  
Retinal Photocoagulation

Aim: The aim of this study was to investigate the expression of platelet-derived growth factor-C in aqueous humor of patients with neovascular glaucoma and its correlation with vascular endothelial growth factor. Methods: This study involved 62 eyes of 62 patients with advanced neovascular glaucoma requiring transscleral cyclophotocoagulation. Aqueous humor was collected through paracentesis. Samples from 11 eyes of 11 patients with age-related cataract were collected as control. Concentrations of platelet-derived growth factor-C and vascular endothelial growth factor in aqueous humor were quantified by enzyme-linked immunosorbent assay. Meanwhile, the correlations between the concentrations of platelet-derived growth factor-C and vascular endothelial growth factor were analyzed. The elements including retinal photocoagulation treatment, iris neovascularization grade, and primary fundus disease were also studied to find out their roles in the concentrations of the two factors. Results: The vascular endothelial growth factor and platelet-derived growth factor-C concentrations in aqueous humor from controls were (679.54 ± 49.81) pg/mL and (18.60 ± 1.85) pg/mL, respectively. Both of them were significantly lower than neovascular glaucoma patients ( p < 0.001). The vascular endothelial growth factor and platelet-derived growth factor-C concentrations of neovascular glaucoma patients treated with retinal photocoagulation were (1095.99 ± 52.71) pg/mL and (28.55 ± 0.94) pg/mL, respectively, which were both significantly lower than those of untreated neovascular glaucoma patients, (1146.28 ± 69.57) pg/mL and (30.04 ± 1.64) pg/mL ( p = 0.008, p = 0.034). There was a weak correlation between the expression level of vascular endothelial growth factor and platelet-derived growth factor-C in aqueous humor with neovascular glaucoma ( r = 0.346, p = 0.006). However, iris neovascularization grade and primary fundus disease were not significant elements in the expression level of vascular endothelial growth factor and platelet-derived growth factor-C. Conclusion: Higher concentrations of vascular endothelial growth factor and platelet-derived growth factor-C were found in aqueous humor of patients with neovascular glaucoma compared with control, which could be lowered by retinal photocoagulation to some extent. Platelet-derived growth factor-C inhibitors may be another potential target for ocular neovascular diseases.

scholarly journals Focus on Molecules: Platelet-derived growth factor C, PDGF-C

2008 ◽  
Vol 86 (5) ◽  
pp. 711-712 ◽  
Author(s):  
Hetian Lei ◽  
Andrius Kazlauskas
Keyword(s):  
Growth Factor ◽  
Platelet Derived Growth Factor ◽  
Factor C
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