scholarly journals Polymorphisms in mitotic checkpoint-related genes can influence survival outcomes of early-stage non-small cell lung cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (37) ◽  
pp. 61777-61785 ◽  
Author(s):  
Hyo Gyoung Kang ◽  
Seung Soo Yoo ◽  
Jin Eun Choi ◽  
Mi Jeong Hong ◽  
Sook Kyung Do ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Mitotic Checkpoint ◽  
Small Cell ◽  
Survival Outcomes ◽  
Small Cell Lung

scholarly journals Functional intronic variant of SLC 5A10 affects DRG 2 expression and survival outcomes of early‐stage non‐small‐cell lung cancer

2018 ◽  
Vol 109 (12) ◽  
pp. 3902-3909 ◽  
Author(s):  
Mi Jeong Hong ◽  
Seung Soo Yoo ◽  
Jin Eun Choi ◽  
Hyo‐Gyoung Kang ◽  
Sook Kyung Do ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Survival Outcomes ◽  
Small Cell Lung

VEGFPolymorphisms and Survival in Early-Stage Non–Small-Cell Lung Cancer

2008 ◽  
Vol 26 (6) ◽  
pp. 856-862 ◽  
Author(s):  
Rebecca Suk Heist ◽  
Rihong Zhai ◽  
Geoffrey Liu ◽  
Wei Zhou ◽  
Xihong Lin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Massachusetts General Hospital ◽  
Early Stage ◽  
Small Cell ◽  
Rank Test ◽  
Survival Outcomes ◽  
Small Cell Lung ◽  
Vegf Polymorphisms

PurposePolymorphisms in the VEGF gene have been identified that are believed to have functional activity. We hypothesized that such polymorphisms may affect survival outcomes among early-stage non—small-cell lung cancer (NSCLC) patients.Patients and MethodsWe evaluated the relationship between VEGF polymorphisms and overall survival (OS) among patients with early-stage NSCLC treated with surgical resection at Massachusetts General Hospital from 1992 to 2001. We specifically investigated the VEGF polymorphisms +936C>T (rs3025039), −460T>C ( rs833061 ), and +405G>C (rs2010963). Analyses of genotype associations with survival outcomes were performed using Cox proportional hazards models, Kaplan-Meier methods, and the log-rank test.ResultsThere were 462 patients and 237 deaths. Patients carrying the variant C allele of the VEGF +405G>C polymorphism had significantly improved survival (crude hazard ratio [HR] = 0.70; 95% CI, 0.54 to 0.90; P = .006; adjusted HR = 0.70; 95% CI, 0.54 to 0.91; P = .008). Five-year OS for patients carrying the variant C allele of the VEGF +405G>C polymorphism was 61% (95% CI, 54% to 67%) versus 51% (95% CI, 43% to 59%) for those who had the wild-type variant. There was a trend toward improved survival among patients carrying the variant T allele of the VEGF +936C>T polymorphism (crude HR = 0.74; 95% CI, 0.53 to 1.03; P = .07; adjusted HR = 0.73; 95% CI, 0.52 to 1.03; P = .07). Moreover, patients with higher number of variant alleles of the +405G>C and +936C>T polymorphisms had better survival. There was no association found with the −460T>C polymorphism.ConclusionPolymorphisms in VEGF may affect survival in early-stage lung cancer.

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