scholarly journals Methylomics of nitroxidative stress on precancerous cells reveals DNA methylation alteration at the transition from in situ to invasive cervical cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (39) ◽  
pp. 65281-65291 ◽  
Author(s):  
Po-Hsuan Su ◽  
Yao-Wen Hsu ◽  
Rui-Lan Huang ◽  
Yu-Chun Weng ◽  
Hui-Chen Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Invasive Cervical Cancer ◽  
Methylation Alteration ◽  
Nitroxidative Stress

scholarly journals Human papillomavirus type 16 genomic variation in women with subsequent in situ or invasive cervical cancer: prospective population-based study

2018 ◽  
Vol 119 (9) ◽  
pp. 1163-1168 ◽  
Author(s):  
Laila Sara Arroyo-Mühr ◽  
Camilla Lagheden ◽  
Emilie Hultin ◽  
Carina Eklund ◽  
Hans-Olov Adami ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Invasive Cervical Cancer ◽  
Population Based ◽  
Genomic Variation ◽  
Population Based Study ◽  
Human Papillomavirus Type 16

scholarly journals Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

2010 ◽  
Vol 129 (2) ◽  
pp. 449-459 ◽  
Author(s):  
Carlos A. González ◽  
Noemie Travier ◽  
Leila Luján-Barroso ◽  
Xavier Castellsagué ◽  
F. Xavier Bosch ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Invasive Cervical Cancer ◽  
Dietary Factors ◽  
Cervical Cancer Risk ◽  
Nutrition Study ◽  
Prospective Investigation

scholarly journals Analysis of Aberrant DNA Methylation and Human Papillomavirus DNA in Cervicovaginal Specimens to Detect Invasive Cervical Cancer and Its Precursors

2004 ◽  
Vol 10 (10) ◽  
pp. 3396-3400 ◽  
Author(s):  
Andreas Widschwendter ◽  
Conny Gattringer ◽  
Lennart Ivarsson ◽  
Heidi Fiegl ◽  
Alois Schneitter ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Human Papillomavirus ◽  
Invasive Cervical Cancer ◽  
Aberrant Dna Methylation ◽  
Papillomavirus Dna

Plasma proteomic profiling for detecting and differentiating in situ and invasive carcinomas of the uterine cervix

2006 ◽  
Vol 16 (3) ◽  
pp. 1216-1224 ◽  
Author(s):  
Y. W. Lin ◽  
H. C. Lai ◽  
C. Y. Lin ◽  
J. Y. Chiou ◽  
H. A. Shui ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Plasma Protein ◽  
Classification Tree ◽  
Invasive Cervical Cancer ◽  
Protein Profiling ◽  
Protein Markers ◽  
Proteomic Profiling ◽  
Cervical Cancers ◽  
Protein Chips

The objective of this study was to identify multiple plasma protein markers that might be characteristic of in situ and invasive cervical cancers. Plasma samples obtained from patients with in situ cervical cancer (carcinoma in situ [CIS], n = 32), from patients with early invasive cervical cancer without lymph node metastasis (squamous cell carcinoma [SCC], n = 60), and from age-matched disease-free controls (n = 37) were analyzed by cation-exchange protein chips and surface-enhanced laser desorption and ionization time-of-flight mass spectrometry. A classification tree defined by six protein peaks could discriminate 84 of the 92 cancers (CIS and SCC) and 36 of the 37 controls, with 91% sensitivity and 97% specificity. In comparing the CIS and SCC samples, two protein peaks with Mr values of 6586.41 and 3805.68 were able to classify 55 of the 60 SCC and 31 of the 32 CIS samples, with 92% sensitivity and 97% specificity. This study demonstrates for the first time the feasibility of differentiating in situ and invasive cervical cancers through plasma protein profiling. Identification of the proteins different in invasive and in situ cancer may be of great value in the understanding of cervical cancer invasion and in the development of novel therapeutic intervention.

In situ/invasive cervical cancer ratios: Impact of cancer education and screening

1988 ◽  
Vol 3 (2) ◽  
pp. 121-125 ◽  
Author(s):  
James Foster ◽  
Bart Holland ◽  
Donald Louria ◽  
Lydia Stinson
Keyword(s):  
Cervical Cancer ◽  
Cancer Education ◽  
Invasive Cervical Cancer

scholarly journals Association Between Type-specific HPV Infections and hTERT DNA Methylation in Patients with Invasive Cervical Cancer

2016 ◽  
Vol 13 (6) ◽  
pp. 483-492 ◽  
Author(s):  
MÓNICA MOLANO ◽  
PABLO MORENO-ACOSTA ◽  
NICOLÁS MORALES ◽  
MARCELA BURGOS ◽  
LINA BUITRAGO ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Invasive Cervical Cancer

scholarly journals Integration of human papillomavirus type 16 in cervical cancer cells

Open Medicine ◽  
2014 ◽  
Vol 10 (1) ◽  
Author(s):  
Zivile Gudleviciene ◽  
Daiva Kanopiene ◽  
Ausra Stumbryte ◽  
Raminta Bausyte ◽  
Edgaras Kirvelaitis ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Invasive Cervical Cancer ◽  
Additional Test ◽  
Human Papillomavirus Type 16 ◽  
Non Invasive ◽  
E2 Gene ◽  
Episomal Hpv16 ◽  
The Status ◽  
Cervical Cancer Cells

AbstractCervical cancer remains an important cause of women morbidity and mortality. The progression of cervical pathology correlates with the HPV integration into the host genome. However, the data on the viral integration status in cervical dysplasias are controversial. The aim of the current study was to evaluate the status of HPV integration in two types of cervical pathology – invasive and non invasive cervical cancer (e.g. carcinoma in situ). 156 women were included in the study: 66 women were diagnosed with invasive cervical cancer (CC) and 90 with non invasive cervical cancer (carcinoma in situ, CIS). 74.2% [95% PI: 63.64÷84.76] of specimens collected from women with diagnosed CC and 85.6% [95% PI: 85.53÷92.85] of CIS specimens were positive for HPV. The most prevalent HPV genotype in both groups was HPV16. To evaluate HPV integration, three selected HPV16 E2 gene fragments were analyzed by PCR. In the majority of CC and CIS specimens the amplification of all three HPV16 E2 gene fragments was observed. The episomal HPV16 form was detected in the majority of CC and CIS specimens. The deletion of all three HPV16 E2 gene fragments was detected in 9.4% of CC specimens and 2.2% of CIS specimens. Finally, integration status could not be used as diagnostical additional test to distinguish between invasive and non invasive cervical cancer.

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