scholarly journals The shortening of leukocyte telomere length relates to DNA hypermethylation of LINE-1 in type 2 diabetes mellitus

Oncotarget ◽  
2017 ◽  
Vol 8 (43) ◽  
pp. 73964-73973 ◽  
Author(s):  
Yue Wu ◽  
Wei Cui ◽  
Donghong Zhang ◽  
Wei Wu ◽  
Zhuo Yang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
Dna Hypermethylation

scholarly journals TELOMERES LENGTH IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ITS RELATION TO METABOLIC PROFILE

2020 ◽  
Vol 66 (6) ◽  
pp. 49-55
Author(s):  
N.V. Kharchenko ◽  
◽  
M.S. Romanenko ◽  
L.L. Sineok ◽  
D.S. Krasnienkov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Waist Circumference ◽  
Telomere Length ◽  
Metabolic Profile ◽  
Leukocyte Telomere Length ◽  
C Reactive Protein ◽  
Reactive Protein

To study leukocyte telomere length and its relationship with metabolic profile 35 patients with metabolic syndrome and type 2 diabetes mellitus (T2DM) and 21 healthy people of middle age (35-59 years) were examined. The anthropometric characteristics of obesity, indicators of lipid and glucose metabolism, alanin aminotransferase (ALT) and high sensitive C-reactive protein levels were studied. The relative average telomere length was determined by the method of monochrome multiplex quantitative real time polymerase chain reaction. Patients with T2DM had higher BMI, waist circumference, higher high sensitive C-reactive protein, ALT and glucose levels and a worse lipid profile (p <0.05). At the same time, the median telomere length did not differ between groups. Nevertheless, in the T2DM group the telomere length inversely correlated with body weight (r = –0.35; p < 0.05), BMI (r = –0.36; p < 0.05), waist circumference (r = –0.34; p < 0.05) and ALT level (r = –0,44; p<0,05) in contrast to healthy subjects. No relationship was found between the telomere length and the level of fasting glycemia, as well as the age of the participants of both groups. Thus, in T2DM patients increase in BMI, waist circumference and ALT level were associated with a shorter leukocyte telomere length. Despite the worse metabolic profile, the telomere length in middle-aged T2DM patients did not differ from that in the control group. This indicates that the leukocyte telomere length is influenced not only by the presence of T2DM and the metabolic profile indicators, but, obviously, by other factors as well.

Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study

2010 ◽  
Vol 155 (4) ◽  
pp. 166-169 ◽  
Author(s):  
Robert Y.L. Zee ◽  
Amy J. Castonguay ◽  
Nathaniel S. Barton ◽  
Soren Germer ◽  
Mitchell Martin
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Telomere Length ◽  
Case Control Study ◽  
Case Control ◽  
Leukocyte Telomere Length ◽  
Control Study

Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus

2011 ◽  
Vol 28 (11) ◽  
pp. 1388-1394 ◽  
Author(s):  
R. Testa ◽  
F. Olivieri ◽  
C. Sirolla ◽  
L. Spazzafumo ◽  
M. R. Rippo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Telomere Length ◽  
Leukocyte Telomere Length

scholarly journals Leukocyte telomere length is inversely associated with post-load but not with fasting plasma glucose levels

2017 ◽  
Vol 242 (7) ◽  
pp. 700-708 ◽  
Author(s):  
Mykola Khalangot ◽  
Dmytro Krasnienkov ◽  
Alexander Vaiserman ◽  
Ivan Avilov ◽  
Volodymir Kovtun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Telomere Length ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Leukocyte Telomere Length ◽  
Glucose Levels ◽  
Fasting Plasma

Type 2 diabetes mellitus is characterized by shorter leukocyte telomere length, but the relationship between leukocyte telomere length and type 2 diabetes mellitus development is rather questioned. Fasting and post-load glycaemia associated with different types of insulin resistance and their relation with leukocyte telomere length remains unknown. We compared leukocyte telomere length and fasting or post-load glucose levels in persons who do not receive glucose lowering treatment. For 82 randomly selected rural residents of Ukraine, aged 45+, not previously diagnosed with type 2 diabetes mellitus, the WHO oral glucose tolerance test and anthropometric measurements were performed. Leukocyte telomere length was measured by standardized method of quantitative monochrome multiplex polymerase chain reaction in real time. Spearman’s or Pearson’s rank correlation was used for correlation analysis between fasting plasma glucose or 2-h post-load plasma glucose levels and leukocyte telomere length. Logistical regression models were used to evaluate risks of finding short or long telomeres associated with fasting plasma glucose or 2-h post-load plasma glucose levels. No association of fasting plasma glucose and leukocyte telomere length was revealed, whereas 2-h post-load plasma glucose levels demonstrated a negative correlation ( P < 0.01) with leukocyte telomere length. Waist circumference and systolic blood pressure were negatively related ( P = 0.03) with leukocyte telomere length in men. Oral glucose tolerance test result-based glycemic categories did not show differences between mean leukocyte telomere length in categories of normal fasting plasma glucose and 2-h post-load plasma glucose (NGT, n = 33); diabetes mellitus (DM), n = 18 and impaired fasting glucose/tolerance (IFG/IGT, n = 31) levels. A correlation relationship between leukocyte telomere length and 2-h post-load plasma glucose level in NGT; IFG/IGT and DM groups ( P = 0.027; 0.029 and 0.049, respectively) was revealed; the association between leukocyte telomere length and fasting plasma glucose was confirmed in DM group only ( P = 0.009). Increase of 2-h post-load plasma glucose (but not fasting plasma glucose) level improves the chances of revealing short telomeres: OR 1.52 (95% CI 1.04–2.22), P = 0.03. After the adjustment for age, gender, waist circumference, systolic blood pressure, and fasting plasma glucose, these phenomena remain significant. We conclude that 2-h post-load plasma glucose but not fasting plasma glucose is inversely associated with leukocyte telomere length. Impact statement • Contradictory epidemiologic data have been obtained about the link between the leucocyte telomere length (LTL) and diabetes. Type 2 diabetes (T2D) is likely to be pathophysiologically heterogeneous, but comparison of the association of LTL separately with fasting plasma glucose (FPG) and 2-h post-load plasma glucose (2hPG) levels has not been done before. Thus, the study of LTL changes associated with different types of hyperglycaemia, that largely determine the heterogenity of T2D is important. • In a population-based study of rural Ukrainians, we were the first to demonstrate that the increase of 2hPG (but not FPG) level increases the chances of revealing short telomeres. • The obtained data can help to clarify the relationship between the LTL shortening and different conditions of the insulin resistance (mainly liver resistance in high FPG and mostly muscle and adipose tissue resistance in high 2hPG).

Telomere length, telomerase activity and mechanisms change in patients with type 2 diabetes mellitus

2016 ◽  
Vol 62 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Natalia Vasil'evna Brailova ◽  
Ekaterina Nail'evna Dudinskaya ◽  
Olga Nikolaevna Tkacheva ◽  
Marina Vladimirovna Shestakova ◽  
Irina Dmitrievna Strazhesko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Telomere Length ◽  
Chronic Inflammation ◽  
Telomerase Activity ◽  
Control Group ◽  
Diabetic Patients

Aim.To study the association of chronic inflammation, oxidative stress with telomere biology in people with type 2 diabetes mellitus (T2DM).Material and Methods.A total 50 patients with T2D and without cardiovascular disease (CVD) and 139 people from control group were included in the study. All subjects were measured for carbohydrate metabolism; oxidative stress (malondialdehyde (MDA)); inflammation (C-reactive protein — CRP, fibrinogen, interleukin-6); lymphocyte telomere length, telomerase activity.Results.In diabetic patients telomeres were shorter than in controls (9.59±0.54 and 9.76±0.47; p=0.031), telomerase activity was lower (0.47±0.40 and 0.62±0.36; p=0.039), inflammation (CRP, elevated fibrinogen) was higher. All patients were divided by telomere length. In T2DM group CRP was higher in patients with «short» telomeres (7.39±1.47 and 3.59±0.58 mg/L; p=0.02). There were no significant differences in the level of chronic inflammation and oxidative stress in ‘long’ telomeres group: CRP 3.59±0.58 and 3.66±0.50 mg/L (p=0.93), MDA 2.81±0.78 and 3.24±0.78 mmol/l (p=0.08). Diabetic patients in «short» telomeres group had greater chronic inflammation: CRP 7.39±1.47 and 4.03±0.62 mg/L (p=0.046), increased fibrinogen, 0.371 and 0.159 (p=0.022). All patients were divided by telomerase activity. Severity of chronic inflammation was greatest in T2DM and the «low» activity of telomerase. There were relationship between telomere length and CRP in T2DM patients (r=–0.40; p=0.004).Conclusions. Chronic inflammation and cell aging were more pronounced in patients with T2DM. However, despite diabetes, signs of chronic inflammation were minimal in patients with «long» telomeres compared to healthy people. Perhaps long telomeres protect diabetic patients from the damaging effect of chronic inflammation.

scholarly journals Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease

2018 ◽  
Vol 70 ◽  
pp. S173-S176 ◽  
Author(s):  
Shobhit Piplani ◽  
Nadezdha Niyarah Alemao ◽  
Madhav Prabhu ◽  
Sameer Ambar ◽  
Yashasvi Chugh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Telomere Length ◽  
Ischemic Heart
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