scholarly journals Long-term cigarette smoke exposure inhibits histone deacetylase 2 expression and enhances the nuclear factor-κB activation in skeletal muscle of mice

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 56726-56736 ◽  
Author(s):  
Dongmei Huang ◽  
Zhiying Ma ◽  
Yili He ◽  
Ying Xiao ◽  
Honglin Luo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Histone Deacetylase ◽  
Cigarette Smoke ◽  
Nuclear Factor Κb ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Nuclear Factor ◽  
Histone Deacetylase 2

scholarly journals Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice

2012 ◽  
Vol 5 (3) ◽  
pp. 333-341 ◽  
Author(s):  
M. Rinaldi ◽  
K. Maes ◽  
S. De Vleeschauwer ◽  
D. Thomas ◽  
E. K. Verbeken ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction

scholarly journals Effect of long-term maternal smoking on the offspring’s lung health

2017 ◽  
Vol 313 (2) ◽  
pp. L416-L423 ◽  
Author(s):  
Surpon Sukjamnong ◽  
Yik Lung Chan ◽  
Razia Zakarya ◽  
Sonia Saad ◽  
Pawan Sharma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoke ◽  
Maternal Smoking ◽  
Smoke Exposure ◽  
Male Offspring ◽  
Mitogen Activated Protein Kinase ◽  
Cigarette Smoke Exposure ◽  
Nuclear Factor ◽  
The Impact

Maternal smoking during pregnancy contributes to long-term health problems in offspring, especially respiratory disorders that can manifest in either childhood or adulthood. Receptors for advanced glycation end products (RAGE) are multiligand receptors abundantly localized in the lung, capable of responding to by-products of reactive oxygen species and proinflammatory responses. RAGE signaling is a key regulator of inflammation in cigarette smoking-related pulmonary diseases. However, the impact of maternal cigarette smoke exposure on lung RAGE signaling in the offspring is unclear. This study aims to investigate the effect of maternal cigarette smoke exposure (SE), as well as mitochondria-targeted antioxidant [mitoquinone mesylate (MitoQ)] treatment, during pregnancy on the RAGE-mediated signaling pathway in the lung of male offspring. Female Balb/c mice (8 wk) were divided into a sham group (exposed to air), an SE group (exposed to cigarette smoke), and an SE + MQ group (exposed to cigarette smoke with MitoQ supplement from mating). The lungs from male offspring were collected at 13 wk. RAGE and its downstream signaling, including nuclear factor-κB and mitogen-activated protein kinase family consisting of extracellular signal-regulated kinase 1, ERK2, c-JUN NH2-terminal kinase (JNK), and phosphorylated JNK, in the lung were significantly increased in the SE offspring. Mitochondrial antioxidant manganese superoxide dismutase was reduced, whereas IL-1β and oxidative stress response nuclear factor (erythroid-derived 2)-like 2 were significantly increased in the SE offspring. Maternal MitoQ treatment normalized RAGE, IL-1β, and Nrf-2 levels in the SE + MQ offspring. Maternal SE increased RAGE and its signaling elements associated with increased oxidative stress and inflammatory cytokines in offspring lungs, whereas maternal MitoQ treatment can partially normalize these changes.

Increased Bone Resorption by Long-Term Cigarette Smoke Exposure in Animal Model

2021 ◽  
Author(s):  
Jader Joel Machado Junqueira ◽  
Juliana Dias Lourenço ◽  
Kaique Rodrigues da Silva ◽  
Vanda Jorgetti ◽  
Rodolfo Vieira ◽  
...  
Keyword(s):  
Animal Model ◽  
Bone Resorption ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure

scholarly journals Long-Term Cigarette Smoke Exposure in a Mouse Model of Ciliated Epithelial Cell Function

2010 ◽  
Vol 43 (6) ◽  
pp. 635-640 ◽  
Author(s):  
Samantha M. Simet ◽  
Joseph H. Sisson ◽  
Jacqueline A. Pavlik ◽  
Jane M. DeVasure ◽  
Craig Boyer ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Mouse Model ◽  
Cigarette Smoke ◽  
Cell Function ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Ciliated Epithelial Cell

scholarly journals The Lung Inflammation and Skeletal Muscle Wasting Induced by Subchronic Cigarette Smoke Exposure Are Not Altered by a High-Fat Diet in Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80471 ◽  
Author(s):  
Michelle J. Hansen ◽  
Hui Chen ◽  
Jessica E. Jones ◽  
Shenna Y. Langenbach ◽  
Ross Vlahos ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cigarette Smoke ◽  
High Fat Diet ◽  
Lung Inflammation ◽  
Muscle Wasting ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
High Fat ◽  
Skeletal Muscle Wasting
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