scholarly journals Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

Oncotarget ◽  
2014 ◽  
Vol 5 (3) ◽  
pp. 587-598 ◽  
Author(s):  
Huili Li ◽  
Katherine B. Chiappinelli ◽  
Angela A. Guzzetta ◽  
Hariharan Easwaran ◽  
Ray-Whay Chiu Yen ◽  
...  
Keyword(s):  
Immune Regulation ◽  
Dna Methyltransferase ◽  
Low Doses ◽  
Epithelial Cancers ◽  
Dna Methyltransferase Inhibitor

DNA methyltransferase inhibitor CDA-II inhibits myogenic differentiation

2012 ◽  
Vol 422 (3) ◽  
pp. 522-526 ◽  
Author(s):  
Zirong Chen ◽  
Guorong Jin ◽  
Shuibin Lin ◽  
Xiumei Lin ◽  
Yumei Gu ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Myogenic Differentiation ◽  
Dna Methyltransferase Inhibitor ◽  
Cda Ii

The DNA-methyltransferase inhibitor 5-aza-2-deoxycytidine affectsHumicola griseaenzyme activities and the glucose-mediated gene repression

2017 ◽  
Vol 58 (2) ◽  
pp. 144-153 ◽  
Author(s):  
João Heitor C. Manfrão-Netto ◽  
Thiago M. Mello-de-Sousa ◽  
Astrid R. Mach-Aigner ◽  
Robert L. Mach ◽  
Marcio J. Poças-Fonseca
Keyword(s):  
Dna Methyltransferase ◽  
Gene Repression ◽  
Dna Methyltransferase Inhibitor

scholarly journals Prostaglandin E2 Reverses the Effects of DNA Methyltransferase Inhibitor and TGFB1 on the Conversion of Naive T Cells to iTregs

2019 ◽  
Vol 47 (3) ◽  
pp. 244-253
Author(s):  
Mehmet Sahin ◽  
Emel Sahin
Keyword(s):  
T Cells ◽  
Prostaglandin E2 ◽  
Dna Methyltransferase ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Dna Methyltransferase Inhibitor

Naturally occurring regulatory T cells (nTregs) are produced under thymic (tTregs) or peripherally induced (pTregs) conditions in vivo. On the other hand, Tregs generated from naive T cells in vitro under some circumstances, such as treatment with transforming growth factor-β (TGFB), are called induced Tregs (iTregs). Tregs are especially characterized by FOXP3 expression, which is mainly controlled by DNA methylation. nTregs play important roles in the suppression of immune response and self-tolerance. The prostaglandin E2 (PGE2) pathway was reported to contribute to regulatory functions of tumor-infiltrating nTregs. In this study, we examined whether PGE2 contributes to the formation of iTregs treated with TGFB1 and 5-aza-2′-deoxycytidine (5-aza-dC), which is a DNA methyltransferase inhibitor. We found that the protein and gene expression levels of FOXP3 and IL-10 were increased in 5-aza-dC and TGFB1-treated T cells in vitro. However, the addition of PGE2 to these cells reversed these increments significantly. In CFSE-based cell suppression assays, we demonstrated that PGE2 decreased the suppressive functions of 5-aza-dC and TGFB1-treated T cells.

scholarly journals A Mass Balance and Disposition Study of the DNA Methyltransferase Inhibitor Zebularine (NSC 309132) and Three of Its Metabolites in Mice

2006 ◽  
Vol 12 (19) ◽  
pp. 5826-5833 ◽  
Author(s):  
Jan H. Beumer ◽  
Erin Joseph ◽  
Merrill J. Egorin ◽  
Robert S. Parker ◽  
David Z. D'argenio ◽  
...  
Keyword(s):  
Mass Balance ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase Inhibitor

scholarly journals EP-2314: Novel RG108-derived DNA-methyltransferase inhibitor as a radiosensitizer in glioblastoma cells

2018 ◽  
Vol 127 ◽  
pp. S1277
Author(s):  
C.W. Wee ◽  
J.H. Kim ◽  
H.J. Kim ◽  
S.Y. Suh ◽  
H.C. Kang ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Glioblastoma Cells ◽  
Dna Methyltransferase Inhibitor

Enhancement of epigenetic reprogramming status of porcine cloned embryos with zebularine, a DNA methyltransferase inhibitor

2019 ◽  
Vol 86 (8) ◽  
pp. 1013-1022 ◽  
Author(s):  
Anukul Taweechaipaisankul ◽  
Geon A Kim ◽  
Jun‐Xue Jin ◽  
Sanghoon Lee ◽  
Muhammad Qasim ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Epigenetic Reprogramming ◽  
Dna Methyltransferase Inhibitor
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