scholarly journals Clinical application and outcomes of sentinel node navigation surgery in patients with early gastric cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (43) ◽  
pp. 75607-75616 ◽  
Author(s):  
Takaaki Arigami ◽  
Yoshikazu Uenosono ◽  
Shigehiro Yanagita ◽  
Keishi Okubo ◽  
Takashi Kijima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Sentinel Node ◽  
Clinical Application ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery

Laparoscopic sentinel node navigation surgery for early gastric cancer: a prospective multicenter trial

2016 ◽  
Vol 402 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Naoto Takahashi ◽  
Hiroshi Nimura ◽  
Tetsuji Fujita ◽  
Norio Mitsumori ◽  
Norio Shiraishi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Sentinel Node ◽  
Multicenter Trial ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery ◽  
Prospective Multicenter Trial

666 Endoscopic Submucosal Dissection With Sentinel Node Navigation Surgery (ESN) for Early Gastric Cancer

2012 ◽  
Vol 75 (4) ◽  
pp. AB157
Author(s):  
Won Young Cho ◽  
Gene Hyun Bok ◽  
Wook Hyun Um ◽  
Kwang Yeun Shim ◽  
Chang Gyun Chun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Sentinel Node ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery ◽  
Submucosal Dissection

scholarly journals Validity of modified gastrectomy combined with sentinel node navigation surgery for early gastric cancer

2007 ◽  
Vol 10 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Hironori Ohdaira ◽  
Hiroshi Nimura ◽  
Norio Mitsumori ◽  
Naoto Takahashi ◽  
Hideyuki Kashiwagi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Sentinel Node ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery

Sentinel Node Navigation Surgery for Early Gastric Cancer: Analysis of Factors Which Affect Direction of Lymphatic Drainage

2017 ◽  
Vol 42 (3) ◽  
pp. 766-772 ◽  
Author(s):  
Atsuo Shida ◽  
Norio Mitsumori ◽  
Shuichi Fujioka ◽  
Yuta Takano ◽  
Muneharu Fujisaki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Sentinel Node ◽  
Lymphatic Drainage ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery

Laparoscopic sentinel node navigation surgery versus laparoscopic standard gastrectomy with lymph node dissection in early gastric cancer: Final three-year survival results of multicenter randomized controlled phase III trial (SENORITA trial).

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 4510-4510
Author(s):  
Keun Won Ryu ◽  
Young Woo Kim ◽  
Jae Seok Min ◽  
Ji Yeong An ◽  
Hong Man Yoon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Early Gastric Cancer ◽  
Sentinel Node ◽  
Lymph Node Dissection ◽  
Node Dissection ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery ◽  
Free Survival ◽  
Randomized Controlled

4510 Background: The benefits and hazards of laparoscopic sentinel node navigation surgery (LSNNS), compared with laparoscopic standard gastrectomy (LSG) with lymph node dissection in early gastric cancer (EGC), are unknown. The SENORITA trial investigated the clinical impact of LSNNS in EGC in terms of short-term surgical outcomes, long-term survival and quality of life. Methods: This study is a prospective, multicenter, randomized controlled, non-inferiority trial. Patients with preoperatively diagnosed gastric adenocarcinoma with T1N0 of 3 cm or less in diameter, regardless of histology, except absolute indication for endoscopic resection were eligible. Patients were randomized to LSG or LSNNS using dual tracers. The primary endpoint is 3-year disease-free survival (3yDFS). Planned sample size per arm is 290 patients with the non-inferiority margin of 2.737 in hazard ratio (HR) assuming that LSG achieve 97% 3yDFS, 5% of type 1 error and 80% of power. Three-year recurrence-free survival (3yRFS), overall survival (3yOS) and disease specific death rate (3yDSDR) were evaluated as secondary endpoints. Results: From March 2013 to December 2016, 580 patients were randomized (LSG arm 292 vs. LSNNS arm 288). After 53 patients dropped out before surgery, operation was performed in 527 patients (269 vs. 258), representing the full analysis set. LSG was performed in 266 according to the protocol excluding 3 open conversion. After exclusion of 13 without LSNNS due to various reasons, LSNNS was performed in 245 patients according to the protocol. After median follow up of 47.5 months, 3yDFS were 95.5% and 91.8% (HR 1.901, CI 0.911 – 3.967), respectively. The 3yRFS was 98.9% and 95.2% (p=0.019), and 3yOS was 99.2% and 97.6% (p=0.166), and 3yDSDR was 99.5% and 99.1% (p=0.591), respectively. Conclusion: LSNNS in EGC did not show non-inferiority compared with LSG in terms of 3yDFS. However, 3yOS and 3yDSDR of LSNNS were comparable to LSG by the rescue surgery of recurrence. LSNNS might be an alternative surgical option instead of LSG in selected EGC patients. Clinical trial information: NCT01804998 .

scholarly journals Current status and challenges in sentinel node navigation surgery for early gastric cancer

2017 ◽  
Vol 29 (2) ◽  
pp. 93-99 ◽  
Author(s):  
Bang Wool Eom ◽  
◽  
Young-Il Kim ◽  
Hong Man Yoon ◽  
Soo-Jeong Cho ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Sentinel Node ◽  
Current Status ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery
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