scholarly journals BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1)

Oncotarget ◽  
2017 ◽  
Vol 8 (31) ◽  
pp. 51402-51415 ◽  
Author(s):  
Georgios Pongas ◽  
Marianne K. Kim ◽  
Dong J. Min ◽  
Carrie D. House ◽  
Elizabeth Jordan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Heterochromatin Protein 1 ◽  
Heterochromatin Protein ◽  
Damage Response

scholarly journals Homeodomain-interacting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1γ

Oncogene ◽  
2014 ◽  
Vol 34 (26) ◽  
pp. 3463-3473 ◽  
Author(s):  
Y Akaike ◽  
Y Kuwano ◽  
K Nishida ◽  
K Kurokawa ◽  
K Kajita ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Dna Damage Response ◽  
Heterochromatin Protein ◽  
Interacting Protein ◽  
Damage Response

scholarly journals Interactome Analysis Reveals that Heterochromatin Protein 1γ (HP1γ) Is Associated with the DNA Damage Response Pathway

2016 ◽  
Vol 48 (1) ◽  
pp. 322-333 ◽  
Author(s):  
Hongtae Kim ◽  
Jae Duk Choi ◽  
Byung-Gyu Kim ◽  
Ho Chul Kang ◽  
Jong-Soo Lee
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Heterochromatin Protein ◽  
Damage Response ◽  
Dna Damage Response Pathway

scholarly journals Revisiting the role of heterochromatin protein 1 in DNA repair

2009 ◽  
Vol 185 (4) ◽  
pp. 573-575 ◽  
Author(s):  
Alexander R. Ball ◽  
Kyoko Yokomori
Keyword(s):  
Dna Damage Response ◽  
Histone H3 ◽  
Direct Interaction ◽  
Epigenetic Mark ◽  
Heterochromatin Protein 1 ◽  
Heterochromatin Protein ◽  
Damage Response ◽  
The One ◽  
Methylated Lysine

Heterochromatin protein 1 (HP1) is a conserved factor critical for heterochromatin organization and gene silencing. It is recruited to chromatin by its direct interaction with H3K9me (methylated lysine 9 residue of histone H3), an epigenetic mark for silenced chromatin. Now, Luijsterburg et al. (Luijsterburg, M.S., C. Dinant, H. Lans, J. Stap, E. Wiernasz, S. Lagerwerf, D.O. Warmerdam, M. Lindh, M.C. Brink, J.W. Dobrucki, et al. 2009. J. Cell Biol. 185:577–586) reveal a new H3K9me-independent role for HP1 in the DNA damage response, which is distinct from the one recently reported by Ayoub et al. (Ayoub, N., A.D. Jeyasekharan, J.A. Bernal, and A.R. Venkitaraman. 2008. Nature. 453:682–686).

scholarly journals The Emerging Role of HP1 in the DNA Damage Response

2009 ◽  
Vol 29 (24) ◽  
pp. 6335-6340 ◽  
Author(s):  
Christoffel Dinant ◽  
Martijn S. Luijsterburg
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Dna Damage Response ◽  
Genotoxic Stress ◽  
Active Role ◽  
Dna Breaks ◽  
Heterochromatin Protein 1 ◽  
Damage Response ◽  
Hp1 Proteins

ABSTRACT Heterochromatin protein 1 (HP1) family members are versatile proteins involved in transcription, chromatin organization, and replication. Recent findings now have implicated HP1 proteins in the DNA damage response as well. Cell-biological approaches showed that reducing the levels of all three HP1 isoforms enhances DNA repair, possibly due to heterochromatin relaxation. Additionally, HP1 is phosphorylated in response to DNA damage, which was suggested to initiate the DNA damage response. These findings have led to the conclusion that heterochromatic proteins are inhibitory to repair and that their dissociation from heterochromatin may facilitate repair. In contrast with an inhibitory role, a more active role for HP1 in DNA repair also was proposed based on the finding that all HP1 isoforms are recruited to UV-induced lesions, oxidative lesions, and DNA breaks. The loss of HP1 renders nematodes highly sensitive to DNA damage, and mice lacking HP1β suffer from genomic instability, suggesting that the loss of HP1 is not necessarily beneficial for repair. These findings raise the possibility that HP1 facilitates DNA repair by reorganizing chromatin, which may involve interactions between phosphorylated HP1 and other DNA damage response proteins. Taken together, these studies illustrate an emerging role of HP1 proteins in the response to genotoxic stress.

2118-P: Regulation of Ataxia-Telangiectasia and Rad3-Related (ATR)–Dependent DNA Damage Response by Nitric Oxide in ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Damage Response
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