scholarly journals Dihydroartemisinin induces autophagy-dependent death in human tongue squamous cell carcinoma cells through DNA double-strand break-mediated oxidative stress

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 45981-45993 ◽  
Author(s):  
Xinli Shi ◽  
Li Wang ◽  
Xiaoming Li ◽  
Jing Bai ◽  
Jianchun Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Strand Break ◽  
Double Strand Break ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Human Tongue ◽  
Dna Double Strand Break

Melatonin Exerts Anticancer Effects in Human Tongue Squamous Cell Carcinoma Cells by Promoting Autophagy

2020 ◽  
Vol 40 (11) ◽  
pp. 6295-6303
Author(s):  
EUI-SUK SUNG ◽  
JOO-YOUNG KIM ◽  
YONG TAE AHN ◽  
IL-WOO LEE ◽  
SEONG-WOOK CHOI ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Human Tongue ◽  
Anticancer Effects

NaF-induced Autophagy on SCC25 Human Tongue Squamous Cell Carcinoma Cells

2014 ◽  
Vol 39 (4) ◽  
pp. 195-199
Author(s):  
Jin-Mo Kang ◽  
◽  
Bo-Young Lee ◽  
In-Ryoung Kim ◽  
Yong-Ho Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Tongue Squamous Cell Carcinoma ◽  
Human Tongue

scholarly journals Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1490 ◽  
Author(s):  
Eirini Terpsi Vitti ◽  
Andrzej Kacperek ◽  
Jason L. Parsons
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Ataxia Telangiectasia ◽  
Strand Break ◽  
Double Strand Break ◽  
Neck Squamous Cell Carcinoma ◽  
Dsb Repair ◽  
Dna Double Strand Break

The response of head and neck squamous cell carcinoma (HNSCC) to radiotherapy depends on human papillomavirus type 16 (HPV) status, and where improved outcome and survival is observed in HPV-positive disease. However, strategies to further radiosensitise the tumours, particularly relatively radioresistant HPV-negative HNSCC, are actively being sought. The impact of targeting the major protein kinases involved in the signaling of DNA double-strand break (DSB) repair, namely ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and Rad3-related (ATR), and the catalytic subunit of DNA-dependent protein kinase (DNA-Pkcs), on the radiosensitisation of HNSCC cells was examined. The response to both conventional photon radiotherapy, but also proton beam therapy, was analysed by clonogenic assays and 3D spheroid growth. We observed that inhibition of ATM, ATR, and particularly DNA-Pkcs, caused a significant reduction in HNSCC cell survival post-irradiation with both photons and protons, with less of an impact on the most radiosensitive HPV-positive cell line. The inhibition of DNA-Pkcs and, to a lesser extent ATM, in combination with radiation was also more effective at inhibiting the growth of 3D spheroids derived from relatively radioresistant HPV-negative HNSCC. Similar effects of the inhibitors were observed comparing photon and proton irradiation, demonstrating the potential for targeting DSB repair as an effective combination treatment for HNSCC.

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