scholarly journals Evaluation of crescent formation as a predictive marker in immunoglobulin A nephropathy: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 46436-46448 ◽  
Author(s):  
Xue Shao ◽  
Bingjue Li ◽  
Luxi Cao ◽  
Ludan Liang ◽  
Jingjuan Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Immunoglobulin A ◽  
Predictive Marker ◽  
Immunoglobulin A Nephropathy ◽  
Crescent Formation

Renal Outcomes of Pregnant Patients with Immunoglobulin A Nephropathy: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 49 (3) ◽  
pp. 214-224 ◽  
Author(s):  
Fan Wang ◽  
Jian-Da Lu ◽  
Ying Zhu ◽  
Ting-Ting Wang ◽  
Jun Xue
Keyword(s):  
Systematic Review ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Lupus Nephritis ◽  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Renal Outcomes

Background: Is the prognosis of immunoglobulin A nephropathy (IgAN) influenced by pregnancy and delivery? The answer to this question still remains to be a controversial topic. Here, we undertook a systematic review and meta-analysis to obtain the overall estimate of potential effect of IgAN and pregnancy on each other. Methods: We systematically searched MEDLINE, EMBASE, Chinese Biological Medicine and Cochrane for cohort and case-control studies; a total of 1,378 articles were reviewed and 9 studies were included in the end. OR and mean difference (MD) were calculated with a random-effects model, kidney events and pregnancy outcomes were analyzed respectively. Results: The key finding of the meta-analysis of 145 renal events in 1,198 participants was that there was no difference in renal outcomes (defined as doubling of serum creatinine (SCr), 50% decline in glomerular filtration rate [GFR] and end-stage kidney disease) of pregnant women compared with non-pregnant women who had IgAN (OR 0.90; 95% CI 0.59–1.37; p = 0.63). Subgroup analysis indicated that there was no significant difference between the 2 groups according to sample size, follow-up year, age, level of SCr and proteinuria at baseline. There was no difference in the change of the eGFR/creatinine clearance rate (mL/min/1.73 m2 per year) in IgAN patients with pregnancy compared with non-pregnancy (MD –0.11 mL/min; 95% CI –0.50–0.27; p = 0.57) as well. Women with IgAN had a higher likelihood of pregnancy outcomes compared with the Chinese general population, while they had a lower risk of preterm delivery, preeclampsia and low birth weight compared with those who had lupus nephritis or diabetic nephropathy. Conclusions: Pregnancy did not accelerate kidney disease deterioration in women with IgAN in stages of chronic kidney disease 1–3. Moreover, patients with IgAN had a relatively low risk of adverse pregnancy events compared with those with lupus nephritis or diabetic nephropathy.

scholarly journals Salivary IgA as a Useful Biomarker for Dental Caries in Down Syndrome Patients: A Systematic Review and Meta-analysis

2020 ◽  
Vol 14 (04) ◽  
pp. 665-671
Author(s):  
Hiba Hamid ◽  
Necdet Adanir ◽  
Faris Yahya Ibrahim Asiri ◽  
Khadijah Abid ◽  
Muhammad Sohail Zafar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Down Syndrome ◽  
Dental Caries ◽  
Quality Assessment ◽  
Meta Analysis ◽  
Immunoglobulin A ◽  
Salivary Iga ◽  
Mesh Terms ◽  
Quantitative Synthesis ◽  
Salivary Immunoglobulin A

AbstractThe objective of this systematic review and meta-analysis is to critically analyze and summarize studies reporting association of salivary immunoglobulin A (IgA) levels as a biomarker for dental caries in Down syndrome (DS) patients. Using the keywords salivary [All Fields] AND IgA [All Fields] AND (“down syndrome” [MeSH Terms] OR (“down”[All Fields] AND “syndrome” [All Fields]) OR “down syndrome” [All Fields]), an electronic search was conducted via PubMed and Scopus databases by two authors, H. H. and Z. K. independently. Retrieved studies were screened against the predefined exclusion and inclusion criteria. To estimate the risk of bias, quality assessment of included studies was carried using the Newcastle–Ottawa quality assessment scale for observational studies. Primary search resulted in 10 articles from PubMed and 13 articles from Scopus. Ten studies fulfilled the defined selection criteria and evaluated the salivary IgA (sIgA) level in DS patients with dental caries. Five articles were further analyzed in a quantitative synthesis presented in the meta-analysis. Due to a modified lifestyle and compromised oral hygiene in DS patients, understandably, it is still postulated in the literature that the presence of sIgA can have a protective effect on the occurrence of dental caries as compared with healthy counterparts. As indicated by the present meta-analysis, no conclusions can be drawn as to definitively label sIgA as a biomarker for dental caries. Further, well-designed longitudinal clinical studies and translational research are therefore required before the benchmarking of sIgA as a useful biomarker for dental caries in DS patients with preferable molecular insights.

Influence of physical exercises on salivary immunoglobulin A (sIgA) concentration in athletes: a systematic review with meta-analysis

2021 ◽  
Author(s):  
Thuanny Castilho ◽  
Ludmila da Silva Guimarães ◽  
Helvécio Cardoso Corrêa Póvoa ◽  
Leonardo Santos Antunes ◽  
Lívia Azeredo Alves Antunes
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Immunoglobulin A ◽  
Physical Exercises ◽  
Salivary Immunoglobulin A

The Novel Ultrasonographic Marker of Uterocervical Angle for Prediction of Spontaneous Preterm Birth in Singleton and Twin Pregnancies: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-7
Author(s):  
Kamran Hessami ◽  
Maryam Kasraeian ◽  
Álvaro Sepúlveda-Martínez ◽  
Mauro Cristian Parra-Cordero ◽  
Homeira Vafaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Preterm Birth ◽  
Meta Analysis ◽  
Predictive Marker ◽  
Second Trimester ◽  
Spontaneous Preterm Birth ◽  
Increased Risk ◽  
Study Heterogeneity ◽  
Mean Differences ◽  
Twin Pregnancies

The alteration of the uterocervical angle (UCA) has been proposed to play an important role in spontaneous preterm birth (sPTB). The aim of this systematic review and meta-analysis was to evaluate the evidence on the UCA predictive role in sPTB. In this study, PubMed, Web of Science, Scopus, and Google scholar were systematically searched from inception up to June 2020. Inter-study heterogeneity was also assessed using Cochrane’s <i>Q</i> test and the <i>I</i><sup>2</sup> statistic. Afterward, the random-effects model was used to pool the weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Eleven articles that reported second-trimester UCA of 5,061 pregnancies were included in this study. Our meta-analysis results indicate that a wider UCA significantly increases the risk of sPTB in following cases: all pregnancies (WMD = 15.25, 95% CI: 11.78–18.72, <i>p</i> &#x3c; 0.001; <i>I</i><sup>2</sup> = 75.9%, <i>p</i> &#x3c; 0.001), singleton (WMD = 14.43, 95% CI: 8.79–20.06, <i>p</i> &#x3c; 0.001; <i>I</i><sup>2</sup> = 82.4%, <i>p</i> &#x3c; 0.001), and twin pregnancies (WMD = 15.14, 95% CI: 13.42–16.87, <i>p</i> &#x3c; 0.001; <i>I</i><sup>2</sup> = 0.0%, <i>p</i> = 0.464). A wider ultrasound-measured UCA in the second trimester seems to be associated with the increased risk of sPTB in both singleton and twin pregnancies, which reinforces the clinical evidence that UCA has the potential to be used as a predictive marker of sPTB.

Urinary angiotensinogen as a predictive marker in patients with immunoglobulin A nephropathy

2011 ◽  
Vol 15 (5) ◽  
pp. 720-726 ◽  
Author(s):  
Yang-Gyun Kim ◽  
Se-Bin Song ◽  
Sang-Ho Lee ◽  
Ju-Young Moon ◽  
Kyung-Hwan Jeong ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Predictive Marker ◽  
Immunoglobulin A Nephropathy ◽  
Urinary Angiotensinogen

scholarly journals IgA Vasculitis and COVID-19 in Children: A Systematic Review

2021 ◽  
Author(s):  
Eva Maria Glenn Lecea ◽  
Daniela Aguilar Abisad ◽  
Ana Paredes ◽  
Arielle Hay
Keyword(s):  
Systematic Review ◽  
Causality Assessment ◽  
Case Reports ◽  
Meta Analysis ◽  
Renal Involvement ◽  
Immunoglobulin A ◽  
Case Series ◽  
Iga Vasculitis ◽  
Female Ratio ◽  
Inflammatory Conditions

Abstract Background: Immunoglobulin A vasculitis is the most common form of vasculitis in children. The diagnosis is made clinically and patients will present with a rash, together with gastrointestinal, musculoskeletal, and renal system involvement. Progress in the classification of the systemic vasculitides has facilitated better understanding of the pathogenesis underlying these inflammatory conditions. Over the past year, several cases of IgA vasculitis have been reported in both children and adults in association with SARS-CoV2 infection, raising the question of whether there is any causal or even a synergistic association.Methods: This systematic review was performed following the guidelines of Meta-analysis of Observational Studies in Epidemiology. A literature search was conducted using MEDLINE, SciELO and Google Scholar using the search terms “COVID-19” or “SARS-CoV-2" in combination with “IgA vasculitis”, or “Henoch-Schonlein Purpura”. We considered articles to be eligible for inclusion if they reported a case report or series of cases of IgA vasculitis associated with proven COVID-19 infection. We excluded cases from further review if the case reported was a patient older than 18 years. WHO causality assessment categories were used to standardize case causality. Results: After reviewing the complete article and applying our exclusion criteria, 12 articles describing 12 cases of COVID-19 associated IgA vasculitis in children were included. In 83% of the cases the diagnosis of COVID-19 was made on presentation of IgA symptoms or on presentation to seek medical care. In 17% of cases the SARS Cov-2 test was positive before IgA vasculitis symptoms presentation. The mean age of the patients was 7.3 years of age (SD ±4.8). Male to female ratio was 3:1. Lower extremity purpura was present in all 12 patients. Gastrointestinal manifestations were present in 7 patients. Oligoarthritis was present in 7 patients. Three patients presented renal involvement with hematuria/proteinuria. Conclusions: During the pandemic, several autoimmune phenomena have been described to co-occur with or following COVID-19. The exact role of COVID-19 in the development of these IgA-related diseases is still being explored. Our review of case series and case reports with standardized causality assessment identified 12 cases of IgA vasculitis associated with COVID-19 infection in children.

scholarly journals Lipoprotein (a) level as a risk factor for stroke and its subtype: A systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pradeep Kumar ◽  
Priyanka Swarnkar ◽  
Shubham Misra ◽  
Manabesh Nath
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Meta Analysis ◽  
Predictive Marker ◽  
Large Artery ◽  
Lipoprotein A ◽  
Control Subjects ◽  
Toast Classification ◽  
Subtype A

AbstractThe role of lipoprotein-A [Lp (a)] as a risk factor for stroke is less well documented than for coronary heart disease. Hence, we conducted a systematic review and meta-analysis for the published observational studies in order to investigate the association of Lp (a) levels with the risk of stroke and its subtypes. In our meta-analysis, 41 studies involving 7874 ischemic stroke (IS) patients and 32,138 controls; 13 studies for the IS subtypes based on TOAST classification and 7 studies with 871 Intracerebral hemorrhage (ICH) cases and 2865 control subjects were included. A significant association between increased levels of Lp (a) and risk of IS as compared to control subjects was observed (standardized mean difference (SMD) 0.76; 95% confidence interval (CIs) 0.53–0.99). Lp (a) levels were also found to be significantly associated with the risk of large artery atherosclerosis (LAA) subtype of IS (SMD 0.68; 95% CI 0.01–1.34) as well as significantly associated with the risk of ICH (SMD 0.65; 95% CI 0.13–1.17) as compared to controls. Increased Lp (a) levels could be considered as a predictive marker for identifying individuals who are at risk of developing IS, LAA and ICH.

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