scholarly journals Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 46425-46435 ◽  
Author(s):  
Long Tian ◽  
Rujun Zeng ◽  
Xin Wang ◽  
Cheng Shen ◽  
Yutian Lai ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Pleural Mesothelioma

scholarly journals PD-L1 and prognosis in patients with malignant pleural mesothelioma: a meta-analysis and bioinformatics study

2020 ◽  
Vol 12 ◽  
pp. 175883592096236
Author(s):  
Liu Jin ◽  
Weiling Gu ◽  
Xueqin Li ◽  
Liang Xie ◽  
Linhong Wang ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Malignant Pleural Mesothelioma ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Progression Free Survival ◽  
The Cancer Genome Atlas ◽  
Cochrane Library ◽  
Pleural Mesothelioma ◽  
Significant Prognostic Factor ◽  
Tcga Dataset

Background: The prognostic value of programmed death-ligand 1 (PD-L1) expression in patients with malignant pleural mesothelioma (MPM) has been controversial according to previous investigations. Therefore, we conducted a meta-analysis to assess the potential prognostic significance of PD-L1 expression in MPM. Methods: PubMed, Embase, Web of Science, Scopus, and the Cochrane Library were thoroughly searched for relevant original articles published before 9 April 2020. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of overall survival (OS) and progression-free survival (PFS) were calculated. The results of the meta-analysis were verified using The Cancer Genome Atlas (TCGA) dataset. Results: In total 16 studies were included in our meta-analysis. A high PD-L1 expression was associated with a poor OS (HR = 1.53, 95% CI = 1.28–1.83, p < 0.001), but not a grave PFS (HR = 1.07, 95% CI = 0.82–1.39, p = 0.643) in MPM. Furthermore, the PD-L1 expression correlated with the sarcomatoid + biphasic type of MPM (odds ratio = 4.32, 95% CI = 2.16–8.64, p < 0.001). TCGA data indicated that PD-L1 was a significant prognostic factor for OS (HR = 2.069, 95% CI = 1.136–3.769, p = 0.0175), but not for PFS (HR = 1.205, 95% CI = 0.572–2.539, p = 0.624), which was in accordance with the results of the meta-analysis. Conclusion: A high PD-L1 expression is a significant prognostic factor for poor OS of patients with MPM. We therefore suggest that PD-L1 expression levels can be used to predict the clinical outcomes of patients with MPM in the future.

Prognostic significance of Bax and Fas Ligand in erionite and asbestos induced Turkish malignant pleural mesothelioma

Lung Cancer ◽  
2005 ◽  
Vol 50 (2) ◽  
pp. 189-198 ◽  
Author(s):  
Nurdan Kokturk ◽  
Pinar Firat ◽  
Hadi Akay ◽  
Cem Kadilar ◽  
Can Ozturk ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Fas Ligand ◽  
Prognostic Significance ◽  
Pleural Mesothelioma

Biomarkers for malignant pleural mesothelioma: a meta-analysis

2019 ◽  
Vol 40 (11) ◽  
pp. 1320-1331 ◽  
Author(s):  
Christina N Gillezeau ◽  
Maaike van Gerwen ◽  
Julio Ramos ◽  
Bian Liu ◽  
Raja Flores ◽  
...  
Keyword(s):  
Lung Disease ◽  
Malignant Pleural Mesothelioma ◽  
Meta Analysis ◽  
Pleural Mesothelioma ◽  
Control Groups ◽  
Aggressive Cancer ◽  
Comparison Groups ◽  
The Mean ◽  
Mean Differences ◽  
Healthy Participants

Abstract Malignant pleural mesothelioma (MPM) is a rare but aggressive cancer, and early detection is associated with better survival. Mesothelin, fibulin-3 and osteopontin have been suggested as screening biomarkers. The study conducted a meta-analysis of the mean differences of mesothelin, osteopontin and fibulin-3 in blood and pleural samples. PubMed searches were conducted for studies that measured levels of mesothelin, osteopontin and fibulin-3 in participants with MPM compared with malignancy, benign lung disease or healthy participants. Thirty-two studies with mesothelin levels, 12 studies with osteopontin levels and 9 studies with fibulin-3 levels were included in the meta-analysis. Statistically significant mean differences were seen between MPM patients and all other comparison groups for mesothelin blood and pleural levels. Statistically significant differences in blood osteopontin levels were seen between participants with benign lung disease and healthy participants compared with participants with MPM, but not when comparing participants with cancer with MPM participants. There were not enough studies that reported osteopontin levels in pleural fluid to complete a meta-analysis. Statistically significant differences were seen in both blood and pleural levels of fibulin-3 in MPM patients compared with all other groups. On the basis of these results, mesothelin and fibulin-3 levels appear to be significantly lower in all control groups compared with those with MPM, making them good candidates for screening biomarkers. Osteopontin may be a useful biomarker for screening healthy individuals or those with benign lung disease but would not be useful for screening patients with malignancies.

scholarly journals Diagnostic and prognostic utilities of humoral fibulin-3 in malignant pleural mesothelioma: Evidence from a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 13030-13038 ◽  
Author(s):  
Dongxu Pei ◽  
Yongwei Li ◽  
Xinwei Liu ◽  
Sha Yan ◽  
Xiaolan Guo ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Meta Analysis ◽  
Pleural Mesothelioma

Prognostic significance of circulating secreted protein acidic and rich in cysteine (SPARC) in malignant pleural mesothelioma (MPM).

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 7580-7580
Author(s):  
Steven Chuan-Hao Kao ◽  
Michaela Kirschner ◽  
Mark P. Molloy ◽  
Stephen John Clarke ◽  
Sjaak A. Burgers ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Prognostic Significance ◽  
Pleural Mesothelioma ◽  
Secreted Protein

Prognostic significance of the lymphocyte-to-monocyte ratio in patients with malignant pleural mesothelioma

Lung Cancer ◽  
2015 ◽  
Vol 90 (1) ◽  
pp. 111-117 ◽  
Author(s):  
Tomoko Yamagishi ◽  
Nobukazu Fujimoto ◽  
Hideyuki Nishi ◽  
Yosuke Miyamoto ◽  
Naofumi Hara ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Prognostic Significance ◽  
Pleural Mesothelioma ◽  
Lymphocyte To Monocyte Ratio
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