scholarly journals Self-assembling nanoparticles encapsulating zoledronic acid inhibit mesenchymal stromal cells differentiation, migration and secretion of proangiogenic factors and their interactions with prostate cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 42926-42938 ◽  
Author(s):  
Cinzia Borghese ◽  
Naike Casagrande ◽  
Eliana Pivetta ◽  
Alfonso Colombatti ◽  
Mariarosaria Boccellino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Prostate Cancer Cells ◽  
Self Assembling

scholarly journals Proteomic analysis of zoledronic-acid resistant prostate cancer cells unveils novel pathways characterizing an invasive phenotype

Oncotarget ◽  
2014 ◽  
Vol 6 (7) ◽  
pp. 5324-5341 ◽  
Author(s):  
Maria Rita Milone ◽  
Biagio Pucci ◽  
Katia Bifulco ◽  
Federica Iannelli ◽  
Rita Lombardi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Proteomic Analysis ◽  
Prostate Cancer Cells ◽  
Invasive Phenotype

Effect of androgen signaling in stromal cells on growth of prostate cancer.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 297-297 ◽  
Author(s):  
Chun-Peng Liao ◽  
Leng-Ying Chen ◽  
Andrea Luethy ◽  
Youngsoo Kim ◽  
A. Robert MacLeod ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Stromal Cells ◽  
Culture System ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Epithelial Cancer ◽  
Mesenchymal Transition

297 Background: Interactions between epithelial and stroma cells are important in the development of prostate cancer (PCa). Cancer-associated fibroblasts (CAFs) have been to support tumor progression, metastasis, and differentiation. Androgen receptor (AR) and related pathways are known to support the growth and survival of prostate epithelial cancer cells, the roles of AR-dependent processes in cancerous stroma are less clear. We sought to investigate if AR-dependent pathways present in CAF cells influence the growth and tumorogencity of epithelial cancer cells in relation to androgen-deprivation therapy in prostate cancer. Methods: Murine CAFs were isolated from a well-described PTEN-dependent cancer mouse model (Liao, et al Cancer Res, 2010. 70(18):7294). A co-culture system was developed based on multiple lines of murine CAFs grown along with human prostate cancer epithelial cells, and a murine-specific anti-sense oligonucleotide (ASO) against murine AR was used to specifically suppress AR expression in murine CAFs in this system. RT-PCR was used to investigate changes in gene expression. Results: Using this co-culture system, we found that murine CAFs promoted cell proliferation and colony formation in several human prostate cancer cell lines. Further, these processes were decreased by suppression of AR-expression in CAFs. Expression of genes related to tumorigenicity in epithelial cells were investigated. Markers associated with epithelial-mesenchymal transition (EMT, N-Cad) and “stemness” (OCT4, Sox2, Nanog) were increased in human prostate cancer cells grown with low-AR CAFs. Conclusions: Our data indicates that suppression of AR in CAFs results in down-regulation in the growth and tumorigenicity of prostate cancer cells through pathways related to EMT and “cell reprograming”. As such, development of therapies which inhibit the tumor-promoting pathways present in stromal cells may be one approach to improve the treatment of prostate cancer.

683 ESTRADIOL PROMOTES THE INVASIVE POTENCY OF PROSTATE CANCER CELLS IN A PARACRINE MANNER THROUGH STIMULATION OF PROSTATIC STROMAL CELLS

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Lin Yu ◽  
Jiandang Shi ◽  
Chunyu Wang ◽  
Helmut Klocker ◽  
Doris Mayer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Stromal Cells ◽  
Prostate Cancer Cells ◽  
Stimulation Of

scholarly journals Prostate Cancer Cells and Bone Stromal Cells Mutually Interact with Each Other through Bone Morphogenetic Protein-mediated Signals

2012 ◽  
Vol 287 (24) ◽  
pp. 20037-20046 ◽  
Author(s):  
Hikaru Nishimori ◽  
Shogo Ehata ◽  
Hiroshi I. Suzuki ◽  
Yoko Katsuno ◽  
Kohei Miyazono
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Bone Morphogenetic Protein ◽  
Stromal Cells ◽  
Prostate Cancer Cells ◽  
Morphogenetic Protein
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