scholarly journals Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 32505-32522 ◽  
Author(s):  
Magali E. Ridano ◽  
Paula V. Subirada ◽  
María C. Paz ◽  
Valeria E. Lorenc ◽  
Juan C. Stupirski ◽  
...  
Keyword(s):  
Anti Vegf ◽  
Proliferative Retinopathies

scholarly journals The potential of anti-VEGF (Vasotide) by eye drops to treat proliferative retinopathies

2016 ◽  
Vol 4 (S1) ◽  
pp. S41-S41 ◽  
Author(s):  
Jennifer L. Wilkinson-Berka ◽  
Devy Deliyanti
Keyword(s):  
Eye Drops ◽  
Anti Vegf ◽  
Proliferative Retinopathies

scholarly journals Gaining insight on mitigation of rubeosis iridis by UPARANT in a mouse model associated with proliferative retinopathy

2020 ◽  
Vol 98 (11) ◽  
pp. 1629-1638
Author(s):  
Filippo Locri ◽  
Noemi A. Pesce ◽  
Monica Aronsson ◽  
Maurizio Cammalleri ◽  
Mario De Rosa ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Proliferative Retinopathy ◽  
Vascular Endothelial ◽  
Urokinase Plasminogen Activator Receptor ◽  
Rubeosis Iridis ◽  
Anti Vegf ◽  
Iris Neovascularization ◽  
Proliferative Retinopathies ◽  
Endothelial Growth Factor

Abstract Proliferative retinopathies (PR) lead to an increase in neovascularization and inflammation factors, at times culminating in pathologic rubeosis iridis (RI). In mice, uveal puncture combined with injection of hypoxia-conditioned media mimics RI associated with proliferative retinopathies. Here, we investigated the effects of the urokinase plasminogen activator receptor (uPAR) antagonist—UPARANT—on the angiogenic and inflammatory processes that are dysregulated in this model. In addition, the effects of UPARANT were compared with those of anti-vascular endothelial growth factor (VEGF) therapies. Administration of UPARANT promptly decreased iris vasculature, while anti-VEGF effects were slower and less pronounced. Immunoblot and qPCR analysis suggested that UPARANT acts predominantly by reducing the upregulated inflammatory and extracellular matrix degradation responses. UPARANT appears to be more effective in comparison to anti-VEGF in the treatment of RI associated with PR in the murine model, by modulating multiple uPAR-associated signaling pathways. Furthermore, UPARANT effectiveness was maintained when systemically administered, which could open to novel improved therapies for proliferative ocular diseases, particularly those associated with PR. Key messages • Further evidence of UPARANT effectiveness in normalizing pathological iris neovascularization. • Both systemic and local administration of UPARANT reduce iris neovascularization in a model associated with proliferative retinopathies. • In the mouse models of rubeosis iridis associated with proliferative retinopathy, UPARANT displays stronger effects when compared with anti-vascular endothelial growth factor regimen.

Intravitreale Anti-VEGF-Therapie mit Bevacizumab bei diabetischem Makulaödem

2006 ◽  
Vol 223 (S 2) ◽  
Author(s):  
D Kook ◽  
A Wolf ◽  
AS Neubauer ◽  
SG Priglinger ◽  
A Hofer ◽  
...  
Keyword(s):  
Anti Vegf

Anti-VEGF bei reiner Pigmentepithelabhebung

2007 ◽  
Vol 224 (S 1) ◽  
Author(s):  
L Spetlikova ◽  
O Rudolph ◽  
R Effert
Keyword(s):  
Anti Vegf
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