scholarly journals Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33571-33585 ◽  
Author(s):  
Tomer Shlamkovich ◽  
Lidan Aharon ◽  
William A. Barton ◽  
Niv Papo
Keyword(s):  
Combinatorial Engineering ◽  
Angiopoetin 2

Tuning Transthyretin Amyloidosis Inhibition Properties of Iododiflunisal by Combinatorial Engineering of the Nonsalicylic Ring Substitutions

2014 ◽  
Vol 17 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Maria Vilaró ◽  
Joan Nieto ◽  
Juan Ramón La Parra ◽  
Maria Rosário Almeida ◽  
Alfredo Ballesteros ◽  
...  
Keyword(s):  
Transthyretin Amyloidosis ◽  
Combinatorial Engineering

scholarly journals Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79557 ◽  
Author(s):  
Ruiyang Zou ◽  
Kang Zhou ◽  
Gregory Stephanopoulos ◽  
Heng Phon Too
Keyword(s):  
In Vitro Assembly ◽  
Combinatorial Engineering

Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in Saccharomyces cerevisiae

2017 ◽  
Vol 100 ◽  
pp. 28-36 ◽  
Author(s):  
Pingping Zhou ◽  
Wenping Xie ◽  
Aipeng Li ◽  
Fan Wang ◽  
Zhen Yao ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Combinatorial Engineering

Increased Bleeding Risk in LVAD Patients with Elevated Angiopoetin-2 and TNF-α: Analysis of the PREVENT Multicenter Study

2018 ◽  
Vol 37 (4) ◽  
pp. S71 ◽  
Author(s):  
G.H. Kim ◽  
G. Sayer ◽  
J. Ransom ◽  
M. Keebler ◽  
J. Katz ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Bleeding Risk ◽  
Tnf Α ◽  
Angiopoetin 2

scholarly journals Procalcitonin as a Marker of Comorbid Atrial Fibrillation in Chronic Kidney Disease and History of Sepsis

2020 ◽  
Vol 26 ◽  
pp. 107602962093222 ◽  
Author(s):  
Jack Bontekoe ◽  
Vinod Bansal ◽  
Justin Lee ◽  
Mushabbar Syed ◽  
Debra Hoppensteadt ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Inflammatory Markers ◽  
Systemic Infection ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Inflammatory Biomarker ◽  
History Of ◽  
Angiopoetin 2

Cardiovascular disease and infection are the leading causes of mortality in patients with stage 5 chronic kidney disease on hemodialysis (CKD5-HD). Inflammation is a large component in the pathogenesis of both atrial fibrillation (AF) and sepsis and may link these conditions in CKD5-HD. Procalcitonin (PCT) is an inflammatory biomarker elevated in systemic infection and CKD5-HD, yet its value with regard to comorbid AF has not been thoroughly investigated. The aim of this study sought to evaluate circulating inflammatory markers, including PCT, Angiopoietin-1, Angiopoetin-2, CD40-L, C-reactive protein, d-dimer, and von Willebrand factor in relation to these conditions. Plasma levels of inflammatory markers were measured by enzyme linked immunosorbent assay method in CKD5-HD (n = 97) patients and controls (n = 50). Procalcitonin levels were significantly elevated ( P = .0270) in CKD5-HD with comorbid AF compared to those without AF. Further analysis of patients with a history of sepsis demonstrated significantly elevated levels of PCT ( P = .0405) in those with comorbid AF (160.7 ± 39.5 pg/mL) compared to those without AF (117.4 ± 25.3 pg/mL). This study demonstrates that the inflammatory biomarker PCT is further elevated in the presence of both AF and a history of sepsis in hemodialysis patients and suggests that underlying chronic inflammation following sepsis resolution may place these patients at greater risk of developing AF.

scholarly journals Combinatorial engineering to enhance thermostability of amylosucrase

2008 ◽  
Vol 17 (6) ◽  
pp. 967-976 ◽  
Author(s):  
Stéphane Emond ◽  
Isabelle André ◽  
Kais Jaziri ◽  
Gabrielle Potocki-Véronèse ◽  
Philippe Mondon ◽  
...  
Keyword(s):  
Combinatorial Engineering
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