scholarly journals Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma

Oncotarget ◽  
2017 ◽  
Vol 8 (22) ◽  
pp. 35639-35655 ◽  
Author(s):  
Kiran K. Velpula ◽  
Maheedhara R. Guda ◽  
Kamlesh Sahu ◽  
Jack Tuszynski ◽  
Swapna Asuthkar ◽  
...  
Keyword(s):  
Metabolic Targeting

Metabolic targeting synergizes with MAPK inhibition and delays drug resistance in melanoma

2019 ◽  
Vol 442 ◽  
pp. 453-463 ◽  
Author(s):  
Christina Brummer ◽  
Stephanie Faerber ◽  
Christina Bruss ◽  
Christian Blank ◽  
Ruben Lacroix ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Metabolic Targeting

scholarly journals Metabolic Targeting of Cancer Stem Cells

2020 ◽  
Vol 10 ◽  
Author(s):  
Anna Mukha ◽  
Anna Dubrovska
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Cancer Stem Cells ◽  
Clonal Evolution ◽  
Cancer Therapies ◽  
Intrinsic Resistance ◽  
Anti Cancer ◽  
Target Tumor Cell ◽  
High Degree ◽  
Metabolic Targeting

Most human tumors possess a high heterogeneity resulting from both clonal evolution and cell differentiation program. The process of cell differentiation is initiated from a population of cancer stem cells (CSCs), which are enriched in tumor‐regenerating and tumor‐propagating activities and responsible for tumor maintenance and regrowth after treatment. Intrinsic resistance to conventional therapies, as well as a high degree of phenotypic plasticity, makes CSCs hard-to-target tumor cell population. Reprogramming of CSC metabolic pathways plays an essential role in tumor progression and metastatic spread. Many of these pathways confer cell adaptation to the microenvironmental stresses, including a shortage of nutrients and anti-cancer therapies. A better understanding of CSC metabolic dependences as well as metabolic communication between CSCs and the tumor microenvironment are of utmost importance for efficient cancer treatment. In this mini-review, we discuss the general characteristics of CSC metabolism and potential metabolic targeting of CSC populations as a potent strategy to enhance the efficacy of conventional treatment approaches.

Abstract 4953: Metabolic targeting of chemoresistance perturbs clonal complexity in pancreatic cancer

2018 ◽  
Author(s):  
Sara Loponte ◽  
Denise Corti ◽  
Sahil Seth ◽  
Edoardo Del Poggetto ◽  
I-Lin Ho ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Metabolic Targeting

545 PEPTIDE RECEPTOR TARGETING IS SUPERIOR TO METABOLIC TARGETING FOR IN VIVO IMAGING OF HUMAN PROSTATE CANCER XENOGRAFTS

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Rogier P.J. Schroeder ◽  
Saskia C. Berndsen ◽  
Corine de Ligt ◽  
Susanne Reneman ◽  
Eric P. Krenning ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Receptor Targeting ◽  
Peptide Receptor ◽  
Metabolic Targeting

scholarly journals Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate

2019 ◽  
Vol 10 ◽  
Author(s):  
Saveg Yadav ◽  
Shrish Kumar Pandey ◽  
Yugal Goel ◽  
Mithlesh Kumar Temre ◽  
Sukh Mahendra Singh
Keyword(s):  
Tumor Metabolism ◽  
Metabolic Targeting
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