scholarly journals Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models

Oncotarget ◽  
2017 ◽  
Vol 8 (18) ◽  
pp. 29865-29886 ◽  
Author(s):  
Giovanni Luca Gravina ◽  
Andrea Mancini ◽  
Claudia Mattei ◽  
Flora Vitale ◽  
Francesco Marampon ◽  
...  
Keyword(s):  
The Novel ◽  
Quinolone Derivative

scholarly journals Original Article. Study of the cytotoxic/toxic potential of the novel anticancer selenodiazoloquinolone on fibroblast cells and 3D skin model

2016 ◽  
Vol 9 (3-4) ◽  
pp. 106-112 ◽  
Author(s):  
Soňa Jantová ◽  
Dominika Topoľská ◽  
Michaela Janošková ◽  
Miroslav Pánik ◽  
Viktor Milata
Keyword(s):  
Morphological Changes ◽  
Cytotoxic Activities ◽  
Fibroblast Cells ◽  
The Novel ◽  
Cytotoxic Effects ◽  
Normal Human ◽  
Quinolone Derivative ◽  
Toxic Potential ◽  
Raw 264.7 Cell Line ◽  
Potential Use

Abstract The new synthetically prepared quinolone derivative 7-ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate (E2h) showed in our previous study cytotoxic effects towards tumor cells and immunomodulatory activities on RAW 264.7 cell line murine macrophages. E2h may have a potential use as a novel chemotherapeutic agent with immunomodulatory properties and the ability to induce apoptotic death of cancer cells. The aim of the present study was to examine the antiproliferative/cytotoxic activities of E2h on human non-cancer fibroblast BHNF-1 cells and reconstructed human epidermis EpiDerm™. Further the effects of E2h on tissue structure and morphology were examined. Cytotoxic/toxic studies showed that selenadiazoloquinolone is not toxic on normal human fibroblast cells BHNF-1 and dimensional skin constructs EpiDerm™. Evaluation of morphological changes in EpiDerm™ showed no change in the construction and morphology of skin tissue treated by E2h compared to control.

scholarly journals Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models

2016 ◽  
Vol 69 ◽  
pp. S62
Author(s):  
C. Festuccia ◽  
G.L. Gravina ◽  
A. Mancini ◽  
F. Vitale ◽  
F. Marampon ◽  
...  
Keyword(s):  
The Novel ◽  
Quinolone Derivative

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon

The Involuntary Capture of Attention by Sound

2010 ◽  
Vol 57 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Fabrice B. R. Parmentier ◽  
Pilar Andrés
Keyword(s):  
Older Adults ◽  
Mismatch Negativity ◽  
Visual Task ◽  
The Novel ◽  
Auditory Oddball ◽  
Current Trial ◽  
Electrophysiological Responses ◽  
Electrophysiological Studies ◽  
The Cross ◽  
Task Sets

The presentation of auditory oddball stimuli (novels) among otherwise repeated sounds (standards) triggers a well-identified chain of electrophysiological responses: The detection of acoustic change (mismatch negativity), the involuntary orientation of attention to (P3a) and its reorientation from the novel. Behaviorally, novels reduce performance in an unrelated visual task (novelty distraction). Past studies of the cross-modal capture of attention by acoustic novelty have typically discarded from their analysis the data from the standard trials immediately following a novel, despite some evidence in mono-modal oddball tasks of distraction extending beyond the presentation of deviants/novels (postnovelty distraction). The present study measured novelty and postnovelty distraction and examined the hypothesis that both types of distraction may be underpinned by common frontally-related processes by comparing young and older adults. Our data establish that novels delayed responses not only on the current trial and but also on the subsequent standard trial. Both of these effects increased with age. We argue that both types of distraction relate to the reconfiguration of task-sets and discuss this contention in relation to recent electrophysiological studies.

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