scholarly journals Circulating tumor cells promote the metastatic colonization of disseminated carcinoma cells by inducing systemic inflammation

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 28418-28430 ◽  
Author(s):  
Yong-Chao Li ◽  
Jiu-Ming Zou ◽  
Chao Luo ◽  
Yu Shu ◽  
Jing Luo ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Systemic Inflammation ◽  
Carcinoma Cells ◽  
Metastatic Colonization

scholarly journals Evaluation of HER2 expression in urothelial carcinoma cells as a biomarker for circulating tumor cells

2020 ◽  
Vol 98 (4) ◽  
pp. 355-367 ◽  
Author(s):  
Alessandro Nini ◽  
Michèle Janine Hoffmann ◽  
Rita Lampignano ◽  
Robert große Siemer ◽  
Guus Dalum ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Carcinoma Cells ◽  
Her2 Expression

scholarly journals EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1632 ◽  
Author(s):  
Anthony Genna ◽  
Aline M. Vanwynsberghe ◽  
Amélie V. Villard ◽  
Charles Pottier ◽  
Julien Ancel ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Cancer Patient ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Crucial Role ◽  
Patient Management ◽  
The Road ◽  
Metastatic Colonization ◽  
On The Road ◽  
Early Phases

Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in the biology of circulating tumor cells (CTCs) and contribute to their heterogeneity. Here, we review major EMT-driven properties that may help hybrid Epithelial/Mesenchymal CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, further supporting the relevance of CTCs in personalized medicine.

scholarly journals Circulating Tumor Cells: A Review of Non–EpCAM-Based Approaches for Cell Enrichment and Isolation

2016 ◽  
Vol 62 (4) ◽  
pp. 571-581 ◽  
Author(s):  
Marta Tellez Gabriel ◽  
Lidia Rodriguez Calleja ◽  
Antoine Chalopin ◽  
Benjamin Ory ◽  
Dominique Heymann
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Biological Information ◽  
Cell Level ◽  
Benign Diseases ◽  
Mesenchymal Transition ◽  
Advantages And Disadvantages ◽  
Cell Enrichment

Abstract BACKGROUND Circulating tumor cells (CTCs) are biomarkers for noninvasively measuring the evolution of tumor genotypes during treatment and disease progression. Recent technical progress has made it possible to detect and characterize CTCs at the single-cell level in blood. CONTENT Most current methods are based on epithelial cell adhesion molecule (EpCAM) detection, but numerous studies have demonstrated that EpCAM is not a universal marker for CTC detection because it fails to detect both carcinoma cells that undergo epithelial-mesenchymal transition (EMT) and CTCs of mesenchymal origin. Moreover, EpCAM expression has been found in patients with benign diseases. A large proportion of the current studies and reviews about CTCs describe EpCAM-based methods, but there is evidence that not all tumor cells can be detected using this marker. Here we describe the most recent EpCAM-independent methods for enriching, isolating, and characterizing CTCs on the basis of physical and biological characteristics and point out the main advantages and disadvantages of these methods. SUMMARY CTCs offer an opportunity to obtain key biological information required for the development of personalized medicine. However, there is no universal marker of these cells. To strengthen the clinical utility of CTCs, it is important to improve existing technologies and develop new, non–EpCAM-based systems to enrich and isolate CTCs.

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a study in 107 patients

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
M Wallwiener ◽  
AD Hartkopf ◽  
S Riethdorf ◽  
J Nees ◽  
FA Taran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Metastatic Breast ◽  
The Impact
Sign in / Sign up

Export Citation Format

Share Document