scholarly journals Integrated analysis of genes associated with poor prognosis of patients with colorectal cancer liver metastasis

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25500-25512 ◽  
Author(s):  
Zhenyuan Qian ◽  
Guobing Zhang ◽  
Guangyuan Song ◽  
Ji Shi ◽  
Lijie Gong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Poor Prognosis ◽  
Integrated Analysis ◽  
Colorectal Cancer Liver Metastasis

Abstract 1151: Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis.

2013 ◽  
Author(s):  
Jeroen A C M Goos ◽  
Veerle M H Coupé ◽  
Begoña Diosdado ◽  
Pien M. Delis-van Diemen ◽  
Cemile Karga ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Poor Prognosis ◽  
Aurora Kinase ◽  
Colorectal Cancer Liver Metastasis ◽  
Aurora Kinase A ◽  
Kinase A

scholarly journals Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis

2013 ◽  
Vol 109 (9) ◽  
pp. 2445-2452 ◽  
Author(s):  
J A C M Goos ◽  
◽  
V M H Coupe ◽  
B Diosdado ◽  
P M Delis-Van Diemen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Poor Prognosis ◽  
Aurora Kinase ◽  
Colorectal Cancer Liver Metastasis ◽  
Aurora Kinase A ◽  
Kinase A

scholarly journals LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit

Oncogene ◽  
2021 ◽  
Author(s):  
Senlin Zhao ◽  
Bingjie Guan ◽  
Yushuai Mi ◽  
Debing Shi ◽  
Ping Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Metastatic Tumor ◽  
Feedback Circuit ◽  
Colorectal Cancer Liver Metastasis ◽  
Positive Feedback Circuit

AbstractGlycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A series of lncRNAs have been identified to function as oncogenic molecules by regulating glycolysis. However, the roles of glycolysis-related lncRNAs in regulating colorectal cancer liver metastasis (CRLM) remain poorly understood. In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Functionally, MIR17HG promoted glycolysis in CRC cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis. More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.

Matrix metalloproteinase 2 and 9 activity in patients with colorectal cancer liver metastasis

2003 ◽  
Vol 90 (12) ◽  
pp. 1556-1564 ◽  
Author(s):  
E. T. Waas ◽  
T. Wobbes ◽  
R. M. L. M. Lomme ◽  
J. DeGroot ◽  
T. Ruers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Colorectal Cancer Liver Metastasis

scholarly journals A comprehensive look at the role of hyperlipidemia in promoting colorectal cancer liver metastasis

2018 ◽  
Vol 9 (16) ◽  
pp. 2981-2986 ◽  
Author(s):  
Yimin Shen ◽  
Caihua Wang ◽  
Yuezhong Ren ◽  
Jun Ye
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Colorectal Cancer Liver Metastasis

Higher Tumor Burden Neutralizes Negative Margin Status in Hepatectomy for Colorectal Cancer Liver Metastasis

2018 ◽  
Vol 26 (2) ◽  
pp. 593-603 ◽  
Author(s):  
Masanori Oshi ◽  
Georgios Antonios Margonis ◽  
Yu Sawada ◽  
Nikolaos Andreatos ◽  
Jin He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Tumor Burden ◽  
Margin Status ◽  
Negative Margin ◽  
Colorectal Cancer Liver Metastasis
Sign in / Sign up

Export Citation Format

Share Document