scholarly journals Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR

Oncotarget ◽  
2017 ◽  
Vol 8 (14) ◽  
pp. 23020-23032 ◽  
Author(s):  
Carminia Maria Della Corte ◽  
Umberto Malapelle ◽  
Elena Vigliar ◽  
Francesco Pepe ◽  
Giancarlo Troncone ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Acquired Resistance ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Egfr Inhibition ◽  
Human Lung Cancer Cells ◽  
Activating Mutation

Proteomic and redox-proteomic study on the role of glutathione reductase in human lung cancer cells

2013 ◽  
Vol 34 (24) ◽  
pp. 3305-3314 ◽  
Author(s):  
Chiao-Yuan Fan ◽  
Hsiu-Chuan Chou ◽  
Yi-Wen Lo ◽  
Yueh-Feng Wen ◽  
Yi-Chih Tsai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Glutathione Reductase ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Proteomic Study

Role of tyrosine specific phosphorylation of cellular proteins, especially EGF receptor and p125FAK in human lung cancer cells

Lung Cancer ◽  
1997 ◽  
Vol 17 (1) ◽  
pp. 69-84 ◽  
Author(s):  
Munehisa Imaizumi ◽  
Masashi Nishimura ◽  
Seijiro Takeuchi ◽  
Mitsuya Murase ◽  
Michinari Hamaguchi
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Egf Receptor ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Cellular Proteins ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells

Lung Cancer ◽  
2005 ◽  
Vol 49 (3) ◽  
pp. 345-351 ◽  
Author(s):  
Tetsuya Oguri ◽  
Hiroyuki Achiwa ◽  
Yuji Bessho ◽  
Hideki Muramatsu ◽  
Hiroyoshi Maeda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Human Lung ◽  
Dihydropyrimidine Dehydrogenase ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3444 ◽  
Author(s):  
Nayeli Shantal Castrejón-Jiménez ◽  
Kahiry Leyva-Paredes ◽  
Shantal Lizbeth Baltierra-Uribe ◽  
Juan Castillo-Cruz ◽  
Marcia Campillo-Navarro ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Oleanolic Acid ◽  
Mitochondrial Membrane ◽  
Human Lung ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

Ursolic and oleanolic acids are natural isomeric triterpenes known for their anticancer activity. Here, we investigated the effect of triterpenes on the viability of A549 human lung cancer cells and the role of autophagy in their activity. The induction of autophagy, the mitochondrial changes and signaling pathway stimulated by triterpenes were systematically explored by confocal microscopy and western blotting. Ursolic and oleanolic acids induce autophagy in A549 cells. Ursolic acid activates AKT/mTOR pathways and oleanolic acid triggers a pathway independent on AKT. Both acids promote many mitochondrial changes, suggesting that mitochondria are targets of autophagy in a process known as mitophagy. The PINK1/Parkin axis is a pathway usually associated with mitophagy, however, the mitophagy induced by ursolic or oleanolic acid is just dependent on PINK1. Moreover, both acids induce an ROS production. The blockage of autophagy with wortmannin is responsible for a decrease of mitochondrial membrane potential (Δψ) and cell death. The wortmannin treatment causes an over-increase of p62 and Nrf2 proteins promote a detoxifying effect to rescue cells from the death conducted by ROS. In conclusion, the mitophagy and p62 protein play an important function as a survival mechanism in A549 cells and could be target to therapeutic control.

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