scholarly journals Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (30) ◽  
pp. 50124-50132 ◽  
Author(s):  
Yang Wu ◽  
Zi-Peng Lu ◽  
Jing-Jing Zhang ◽  
Dong-Fang Liu ◽  
Guo-Dong Shi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Meta Analysis ◽  
Lys751gln Polymorphism

scholarly journals Exercise efficacy and prescription during treatment for pancreatic ductal adenocarcinoma: a systematic review

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dominic O’Connor ◽  
Malcolm Brown ◽  
Martin Eatock ◽  
Richard C. Turkington ◽  
Gillian Prue
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Pancreatic Cancer ◽  
Adjuvant Therapy ◽  
Physical Function ◽  
Meta Analysis ◽  
Ductal Adenocarcinoma ◽  
Key Stakeholders ◽  
The Impact

Abstract Background Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. As such, optimizing physical function through exercise during treatment remains imperative to optimize quality of life either before surgery or during rehabilitation. However, current exercise efficacy and prescription in pancreatic cancer is unknown. Therefore, this study aims to summarise the published literature on exercise studies conducted in patients with pancreatic cancer undergoing treatment with a focus on determining the current prescription and progression patterns being used in this population. Methods A systematic review of four databases identified studies evaluating the effects of exercise on aerobic fitness, muscle strength, physical function, body composition, fatigue and quality of life in participants with pancreatic cancer undergoing treatment, published up to 24 July 2020. Two reviewers independently reviewed and appraised the methodological quality of each study. Results Twelve studies with a total of 300 participants were included. Heterogeneity of the literature prevented meta-analysis. Exercise was associated with improvements in outcomes; however, study quality was variable with the majority of studies receiving a weak rating. Conclusions High quality evidence regarding the efficacy and prescription of exercise in pancreatic cancer is lacking. Well-designed trials, which have received feedback and input from key stakeholders prior to implementation, are required to examine the impact of exercise in pancreatic cancer on key cancer related health outcomes.

scholarly journals A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Evangelina López de Maturana ◽  
◽  
Juan Antonio Rodríguez ◽  
Lola Alonso ◽  
Oscar Lao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Functional Analysis ◽  
Genetic Susceptibility ◽  
In Silico ◽  
Complex Disease ◽  
Meta Analysis ◽  
Low Frequency ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Phenotypic Variance

Abstract Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. Methods We complemented a new conventional PC GWAS (1D) with genome spatial autocorrelation analysis (2D) permitting to prioritize low frequency variants not detected by GWAS. These were further expanded via Hi-C map (3D) interactions to gain additional insight into the inherited basis of PC. In silico functional analysis of public genomic information allowed prioritization of potentially relevant candidate variants. Results We identified several new variants located in genes for which there is experimental evidence of their implication in the biology and function of pancreatic acinar cells. Among them is a novel independent variant in NR5A2 (rs3790840) with a meta-analysis p value = 5.91E−06 in 1D approach and a Local Moran’s Index (LMI) = 7.76 in 2D approach. We also identified a multi-hit region in CASC8—a lncRNA associated with pancreatic carcinogenesis—with a lowest p value = 6.91E−05. Importantly, two new PC loci were identified both by 2D and 3D approaches: SIAH3 (LMI = 18.24), CTRB2/BCAR1 (LMI = 6.03), in addition to a chromatin interacting region in XBP1—a major regulator of the ER stress and unfolded protein responses in acinar cells—identified by 3D; all of them with a strong in silico functional support. Conclusions This multi-step strategy, combined with an in-depth in silico functional analysis, offers a comprehensive approach to advance the study of PC genetic susceptibility and could be applied to other diseases.

scholarly journals Network meta-analysis of Chinese herbal injections combined with the chemotherapy for the treatment of pancreatic cancer

Medicine ◽  
2017 ◽  
Vol 96 (21) ◽  
pp. e7005 ◽  
Author(s):  
Dan Zhang ◽  
Jiarui Wu ◽  
Shi Liu ◽  
Xiaomeng Zhang ◽  
Bing Zhang
Keyword(s):  
Pancreatic Cancer ◽  
Meta Analysis ◽  
Chinese Herbal

The clinicopathological and prognostic significance of PD-L1 expression in pancreatic cancer: A meta-analysis

2018 ◽  
Vol 17 (2) ◽  
pp. 95-100 ◽  
Author(s):  
He-Li Gao ◽  
Liang Liu ◽  
Zi-Hao Qi ◽  
Hua-Xiang Xu ◽  
Wen-Quan Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Meta Analysis ◽  
Prognostic Significance

scholarly journals Comment on “Systematic Review and Meta-Analysis of Diagnostic Accuracy of miRNAs in Patients with Pancreatic Cancer”

2018 ◽  
Vol 2018 ◽  
pp. 1-2 ◽  
Author(s):  
Rama Jayaraj ◽  
Chellan Kumarasamy ◽  
Madurantakam Royam Madhav ◽  
Venkatesh Pandey ◽  
Shanthi Sabarimurugan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pancreatic Cancer ◽  
Diagnostic Accuracy ◽  
Meta Analysis

scholarly journals Impact of diabetes mellitus on the survival of pancreatic cancer: a meta-analysis

2016 ◽  
pp. 1679 ◽  
Author(s):  
Jian Wang ◽  
Hui Shen ◽  
Ming Zhan ◽  
Wei Wang ◽  
Dong Yang
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Cancer ◽  
Meta Analysis

Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis

2015 ◽  
Vol 26 (7) ◽  
pp. 1027-1035 ◽  
Author(s):  
Annaka Schulte ◽  
Nirmala Pandeya ◽  
Jonathan Fawcett ◽  
Lin Fritschi ◽  
Harvey A. Risch ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Helicobacter Pylori ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Pancreatic Cancer Risk
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