scholarly journals Altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional MR imaging study with granger causality analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25021-25031 ◽  
Author(s):  
Li Juan Zheng ◽  
Gui Fen Yang ◽  
Xin Yuan Zhang ◽  
Yun Fei Wang ◽  
Ya Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mr Imaging ◽  
Granger Causality ◽  
Resting State ◽  
Effective Connectivity ◽  
Imaging Study ◽  
Causality Analysis ◽  
Granger Causality Analysis ◽  
Functional Mr Imaging

scholarly journals Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Shangjie Chen ◽  
Lijun Bai ◽  
Maosheng Xu ◽  
Fang Wang ◽  
Liang Yin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Granger Causality ◽  
Effective Connectivity ◽  
Brain Networks ◽  
Brain Regions ◽  
Causality Analysis ◽  
Granger Causality Analysis ◽  
Cognitive States ◽  
Dorsolateral Prefrontal

Evidence from clinical reports has indicated that acupuncture has a promising effect on mild cognitive impairment (MCI). However, it is still unknown that by what way acupuncture can modulate brain networks involving the MCI. In the current study, multivariate Granger causality analysis (mGCA) was adopted to compare the interregional effective connectivity of brain networks by varying needling depths (deep acupuncture, DA; superficial acupuncture, SA) and at different cognitive states, which were the MCI and healthy control (HC). Results from DA at KI3 in MCI showed that the dorsolateral prefrontal cortex and hippocampus emerged as central hubs and had significant causal influences with each other, but significant in HC for DA. Moreover, only several brain regions had remarkable causal interactions following SA in MCI and even few brain regions following SA in HC. Our results indicated that acupuncture at KI3 at different cognitive states and with varying needling depths may induce distinct reorganizations of effective connectivities of brain networks, and DA at KI3 in MCI can induce the strongest and more extensive effective connectivities related to the therapeutic effect of acupuncture in MCI. The study demonstrated the relatively functional specificity of acupuncture at KI3 in MCI, and needling depths play an important role in acupuncture treatments.

scholarly journals A failed top-down control from prefrontal cortex to amygdala in generalized anxiety disorder: evidence from resting-state fMRI with Granger causality analysis

2019 ◽  
Author(s):  
Mengshi Dong ◽  
Likun Xia ◽  
Min Lu ◽  
Chao Li ◽  
Ke Xu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Anxiety Disorder ◽  
Granger Causality ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Effective Connectivity ◽  
Generalized Anxiety ◽  
Causality Analysis ◽  
Top Down ◽  
Granger Causality Analysis

AbstractObjectiveIn generalized anxiety disorder (GAD), abnormal top-down control from prefrontal cortex (PFC) to amygdala is a widely accepted hypothesis through which “emotional dysregulation model” may be explained. However, whether and how the PFC directly exerted abnormal top-down control on amygdala remained largely unknown. We aim to investigate the amygdala-based effective connectivity by using Granger causality analysis (GCA).MethodsThirty-five drug-naive patients with GAD and thirty-six healthy controls (HC) underwent resting-state functional MR imaging. We used seed-based Granger causality analysis to examine the effective connectivity between the bilateral amygdala and the whole brain. The amygdala-based effective connectivity was compared between the two groups.ResultsIn HC, the left middle frontal gyrus exerted inhibitory influence on the right amygdala, while in GAD group, this influence was disrupted (single voxel P < 0.001, Gaussian random field corrected with P < 0.01).ConclusionOur finding might provide new insight into the “insufficient top-down control” hypothesis in GAD.

scholarly journals Altered amygdala effective connectivity in migraine without aura: evidence from resting‐state fMRI with Granger causality analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiaobin Huang ◽  
Di Zhang ◽  
Peng Wang ◽  
Cunnan Mao ◽  
Zhengfei Miao ◽  
...  
Keyword(s):  
Granger Causality ◽  
Resting State ◽  
Migraine Without Aura ◽  
Effective Connectivity ◽  
Inferior Frontal Gyrus ◽  
Superior Temporal Gyrus ◽  
Pain Modulation ◽  
Precentral Gyrus ◽  
Causality Analysis ◽  
Granger Causality Analysis

AbstractBackgroundGranger causality analysis (GCA) has been used to investigate the pathophysiology of migraine. Amygdala plays a key role in pain modulation of migraine attack. However, the detailed neuromechanism remained to be elucidated. We applied GCA to explore the amygdala-based directional effective connectivity in migraine without aura (MwoA) and to determine the relation with clinical characteristics.MethodsForty-five MwoA patients and forty age-, sex-, and years of education-matched healthy controls(HCs) underwent resting-state functional magnetic resonance imaging (fMRI). Bilateral amygdala were used as seed regions in GCA to investigate directional effective connectivity and relation with migraine duration or attack frequency.ResultsMwoA patients showed significantly decreased effective connectivity from right amygdala to right superior temporal gyrus, left superior temporal gyrus and right precentral gyrus compared with HCs. Furthermore, MwoA patients demonstrated significantly decreased effective connectivity from the left amygdala to the ipsilateral superior temporal gyrus. Also, MwoA patients showed enhanced effective connectivity from left inferior frontal gyrus to left amygdala. Effective connectivity outflow from right amygdala to right precentral gyrus was negatively correlated to disease duration.ConclusionsAltered directional effective connectivity of amygdala demonstrated that neurolimbic pain networks contribute to multisensory integration abnormalities and deficits in pain modulation of MwoA patients.

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