scholarly journals MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25005-25020 ◽  
Author(s):  
Yuan Zhao ◽  
Zhiqiang Ling ◽  
Yubin Hao ◽  
Xiaowu Pang ◽  
Xianlin Han ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Sphingosine Kinase ◽  
Neck Squamous Cell Carcinoma ◽  
Sphingosine Kinase 1 ◽  
Downstream Signaling

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition

Head & Neck ◽  
2011 ◽  
Vol 33 (2) ◽  
pp. 178-188 ◽  
Author(s):  
Uttam K. Sinha ◽  
Victor J. Schorn ◽  
Christian Hochstim ◽  
Steven B. Chinn ◽  
Sutao Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Sphingosine Kinase ◽  
Radiation Sensitivity ◽  
Neck Squamous Cell Carcinoma ◽  
Sphingosine Kinase 1

scholarly journals The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma

2018 ◽  
Vol 97 (6) ◽  
pp. 645-653 ◽  
Author(s):  
T. Fukusumi ◽  
J.A. Califano
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Family Members ◽  
Notch Pathway ◽  
Suppressor Gene ◽  
Neck Squamous Cell Carcinoma ◽  
Notch1 Mutations

Comprehensive genomic analyses have been performed for head and neck squamous cell carcinoma (HNSCC), revealing a significant rate of NOTCH1 mutations and identifying NOTCH1 as the second most frequently mutated gene after TP53. Most NOTCH1 mutations are considered inactivating, indicating that NOTCH1 is a tumor suppressor gene. On the other hand, cohorts from Asian populations with HNSCC have shown activating NOTCH1 mutations. HNSCC with NOTCH1 mutations have a worse prognosis than the NOTCH1 wild-type tumors. Additional data on other NOTCH family members have shown that NOTCH promotes HNSCC progression. NOTCH family members, including NOTCH pathway genes, are upregulated in HNSCC compared with normal tissues, and inhibition of the NOTCH pathway decreases cell proliferation and invasion. NOTCH activity in HNSCC is therefore contextual, and NOTCH in HNSCC is considered to have a bimodal role as a tumor suppressor and an oncogene. In this review, recent understandings of NOTCH pathway genes, including NOTCH genes, in HNSCC are described. In addition, the implications of NOTCH pathway alteration for HNSCC-specific NOTCH-targeted cancer therapy are explored.

scholarly journals Frequently Methylated Tumor Suppressor Genes in Head and Neck Squamous Cell Carcinoma

2008 ◽  
Vol 68 (12) ◽  
pp. 4494-4499 ◽  
Author(s):  
Kristi L. Bennett ◽  
Matthew Karpenko ◽  
Mau-ting Lin ◽  
Rainer Claus ◽  
Khelifa Arab ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Suppressor Genes ◽  
Neck Squamous Cell Carcinoma ◽  
Suppressor Genes
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